Gender differences in the association between hyperuricemia and diabetic kidney disease in community elderly patients

Guo, Mei; Niu, Jianying; Li, Sheran; Ye, Xian-Wu; Fang, Hong; Zhao, Yang; Gu, Yong

doi:10.1016/j.jdiacomp.2015.08.016

Cited by 9 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gender differences were also noted in the impact of serum uric acid on DKD risk [ 223 , 224 , 225 ]. In a large Chinese cohort [ 226 ], hyperuricemia was independently associated with an increased risk of DKD in both genders, but, after adjustment for traditional DKD risk factors, the association remained significant only in men.…”

Section: Gender Differences In Dkd Risk Factors and Renoprotective Drugsmentioning

confidence: 99%

Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors

Giandalia

Giuffrida

Gembillo

et al. 2021

IJMS

View full text Add to dashboard Cite

Diabetic kidney disease (DKD) is one of the most serious complications of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). Current guidelines recommend a personalized approach in order to reduce the burden of DM and its complications. Recognizing sex and gender- differences in medicine is considered one of the first steps toward personalized medicine, but the gender issue in DM has been scarcely explored so far. Gender differences have been reported in the incidence and the prevalence of DKD, in its phenotypes and clinical manifestations, as well as in several risk factors, with a different impact in the two genders. Hormonal factors, especially estrogen loss, play a significant role in explaining these differences. Additionally, the impact of sex chromosomes as well as the influence of gene–sex interactions with several susceptibility genes for DKD have been investigated. In spite of the increasing evidence that sex and gender should be included in the evaluation of DKD, several open issues remain uncovered, including the potentially different effects of newly recommended drugs, such as SGLT2i and GLP1Ras. This narrative review explored current evidence on sex/gender differences in DKD, taking into account hormonal, genetic and clinical factors.

show abstract

Section: Gender Differences In Dkd Risk Factors and Renoprotective Drugsmentioning

confidence: 99%

Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors

Giandalia

Giuffrida

Gembillo

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“… 36 , 37 This result was consistent with our previous study, which found that ethnic Chinese people may be prone to albuminuric diabetic kidney disease. 27 The Ruijin and CKD-EPI equations had similar predictive values (~10.0%) for the early stage of reduced renal function (CKD stage 3a).…”

Section: Discussionmentioning

confidence: 88%

“…Details of the data extraction have been described previously. 27 After data cleaning and excluding patients with seriously abnormal Scr (<53 µmol/L or >618 µmol/L) levels, a total of 21,723 cases of older diabetic patients remained. Diabetic history and data from physical examinations, including measurements of blood pressure, body height, weight, waist circumference, fasting blood glucose, HbA1c (measured using standard high-performance liquid chromatography), Scr measured by Jaffe’s kinetic method, and the urinary albumin-to-creatinine ratio (ACR, milligram per gram), were extracted.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of various equations for estimating renal function in elderly Chinese patients with type 2 diabetes mellitus

Guo

Niu

et al. 2017

CIA

Self Cite

View full text Add to dashboard Cite

BackgroundThe clinical assessment of kidney function based on the estimated glomerular filtration rate (GFR) in older patients remains controversial. This study evaluated the concordance and feasibility of using various creatinine-based equations for estimating GFR in elderly Chinese patients with type 2 diabetes mellitus (T2DM).MethodsA cross-sectional analytical study was conducted in 21,723 older diabetic patients (≥60 years) based on electronic health records (EHR) for Minhang District, Shanghai, China. The concordance of chronic kidney disease (CKD) classification among different creatinine-based equations was assessed based on Kappa values, intraclass correlation coefficient (ICC) statistics, and the eGFR agreement between the equations was tested using Bland–Altman plots. The GFR was estimated using the Cockcroft–Gault (CG), Berlin Initiative Study 1 (BIS1), simplified Modification of Diet in Renal Disease (MDRD), MDRD modified for Chinese populations (mMDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), CKD-EPI in Asians (CKD-EPI-Asia), and Ruijin equations.ResultsOverall, the proportion of CKD stages 3–5 (eGFR <60 mL/min/1.73 m2) was calculated as 28.9%, 39.1%, 11.8%, 8.4%, 14.3%, 11.5%, and 12.7% by the eGFRCG, eGFRBIS1, eGFRMDRD, eGFRmMDRD, eGFRCKD-EPI, eGFRCKD-EPI-Asia, and eGFRRuijin equations, respectively. The concordance of albuminuria and decreased eGFR based on the different equations was poor by both the Kappa (<0.2) and ICC (<0.4) statistics. The CKD-EPI-Asia equation resulted in excellent concordance with the CKD-EPI (ICC =0.931), MDRD (ICC =0.963), mMDRD (ICC =0.892), and Ruijin (ICC =0.956) equations for the classification of CKD stages, whereas the BIS1 equation exhibited good concordance with the CG equation (ICC =0.809). In addition, significant differences were observed for CKD stage 1 among all these equations.ConclusionAccurate GFR values are difficult to estimate using creatinine-based equations in older diabetic patients. Kidney function is complex, and the staff need to be aware of the individualized consideration of other risk factors or markers of reduced renal function in clinical practice.

show abstract

“…It is interesting to note that the stratified analyses showed that the reduction of IR was more remarkable in the patients with older age and in the trails with large sample size and normal blood glucose, as well as in patients received the less duration of treatment in our study. It has been reported that serum levels of uric acid were increased with age 9,[40][41][42][43][44] and hyperuricemic patients usually company with relatively higher central obesity, serum lipids and BP, which were closely associated with IR 14,15,42,45,46 . Hence, IR reduction by hypouricemic treatment in patients with older age could be more significant as it was reported older patients who received anti-hyperuricemic agent were more likely to reach SUA goal 47 .…”

Section: Discussionmentioning

confidence: 99%

Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials

Zong

Wang

2021

Afr H. Sci.

View full text Add to dashboard Cite

Objectives: This meta-analysis aimed to investigate whether uric acid lowering treatment can improve β-cell function and insulin sensitivity. Methods: PubMed, Cochrane Library, EMBASE and China Biology Medicine were searched up to March 1, 2020. Rand- omized controlled clinical trials of urate lowering therapy in hyperuricemia patients were included in meta-analysis. Effect size was estimated as mean difference with 95% confidence interval (CI). Results: Our search yielded 7 eligible trials with 503 participants. This meta-analysis showed that uric acid-lowering thera- py decreased fasting insulin -1.43 μIU/ml (weighted mean differences (WMD, 95% CI -2.78 to -0.09), homeostasis model assessment of insulin resistance -0.65 (WMD, 95% CI -1.05 to -0.24), systolic blood pressure -2.45 mm Hg (WMD, 95%CI -4.57 to -0.33) and diastolic blood pressure -3.41 mm Hg (WMD, 95%CI -3.87 to -2.95). However, the treatment had no significant effect on fasting plasma glucose (WMD -0.19 mmol/L, 95%CI -0.42 to 0.05), homeostasis model assessment of β-cell function index (WMD -0.02, 95%CI -0.28 to 0.24), total cholesterol (WMD 0.18 mg/dl; 95%CI, -1.39 to 1.75) and triglyceride (WMD 3.15 mg/dl, 95% CI -9.83 to 16.14). Conclusion: Uric acid-lowering therapies might improve insulin sensitivity and lower blood pressure, but had no significant effect on HOMA-β and serum lipids. Keywords: Hyperuricemia; uric acid lowering treatment; β-cell function; insulin sensitivity.

show abstract

Gender differences in the association between hyperuricemia and diabetic kidney disease in community elderly patients

Cited by 9 publications

References 46 publications

Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors

Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors

Evaluation of various equations for estimating renal function in elderly Chinese patients with type 2 diabetes mellitus

Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials

Contact Info

Product

Resources

About