Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials

Zong, Qunchuan; Ma, Guanyi; Wang, Tao

doi:10.4314/ahs.v21i1.13

Cited by 3 publications

(3 citation statements)

References 62 publications

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“…These improvements are indicative of a positive impact on a patient's long-term prognosis ( 34 ). Furthermore, a meta-analysis of seven eligible trials involving 503 participants with hyperuricemia demonstrated that urate-lowering therapy led to decreases in systolic and diastolic blood pressure, fasting insulin levels, and homeostasis model assessment of insulin resistance ( 35 ). However, it is worth noting that not all trials have shown consistent results, as some failed to provide sufficient evidence to support an effect on blood pressure, proteinuria, or other cardiovascular markers through urate-lowering therapy ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Association between hyperuricemia and long-term mortality in patients with hypertension: results from the NHANES 2001–2018

Yin,

Zhou,

2024

Front. Cardiovasc. Med.

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ObjectiveThe prevalence of hyperuricemia and hypertension is steadily increasing, and these conditions often share common risk factors. This study aimed to investigate the association among hyperuricemia, hypertension, and all-cause mortality in a nationally representative U.S. population.MethodsData for 38,644 participants were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001–2018. Hyperuricemia was defined as a serum urate concentration >420 μmol/L in men and >360 μmol/L in women. Information regarding death outcomes was obtained through the National Death Index (NDI). Multivariate logistic regression, Cox proportional hazards models, and restricted cubic spline (RCS) analyses were used to evaluate the association between hyperuricemia and hypertension in all included participants, as well as long-term mortality in patients with hypertension.ResultsAmong all participants, 6,956 (18.0%) had hyperuricemia, while 31,688 (82.0%) had nonhyperuricemia. According to the adjusted models, hyperuricemia was more strongly associated with hypertension (OR 2.04) than was non-hyperuricemia. During the median follow-up period of 78 months, both hyperuricemia (HR 1.48, 1.95) and hypertension (HR 1.42, 1.69) independently associated with the increased risk of all-cause mortality and cardiovascular mortality, respectively, with the highest risk observed in those with both conditions (HR 1.87, 2.82). RCS analyses revealed nonlinear J-shaped (for hypertension) and U-shaped (for both all-cause and cardiovascular mortality) relationships with serum urate levels.ConclusionsHyperuricemia is associated with an elevated risk of developing hypertension compared to non-hyperuricemia. Among patients with hypertension, those with hyperuricemia are more likely to experience all-cause and cardiovascular mortality during long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

Association between hyperuricemia and long-term mortality in patients with hypertension: results from the NHANES 2001–2018

Yin,

Zhou,

2024

Front. Cardiovasc. Med.

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“…However, these interventions did not yield a significant effect on HOMA-β and serum lipid levels. [28] There is a high degree of variability in the determination of HOMA-IR cutoff levels to define insulin resistance. The distribution of HOMA-IR varies according to the demographic characteristics of the subjects, such as age, sex, and race, making it difficult to estimate the optimal cutoff point.…”

Section: Discussionmentioning

confidence: 99%

“…However, these interventions did not yield a significant effect on HOMA-β and serum lipid levels. [ 28 ]…”

Section: Discussionmentioning

confidence: 99%

What is the relationship between serum uric acid level and insulin resistance?: A case-control study

Asma Sakalli,

Küçükerdem,

Aygün

2023

Medicine

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Diabetes, arises from either an absolute or relative insufficiency of insulin or insulin resistance of peripheral tissues. For assessing long-term blood glucose concentration and insulin resistance, the utilization of glycosylated hemoglobin (HbA1c) and the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) is widespread. Insulin resistance can lead to hyperuricemia by reducing the kidney ability to excrete urate, thus increasing sodium reabsorption. The aim of this study was to investigate the possible relationship between serum uric acid levels and insulin resistance. This was a retrospective case-control study. A total of 2530 applications in 2-year time were included in the study. Patient, known hypertension status, fasting plasma glucose, insulin, uric acid, HDL, low-density lipoprotein (LDL), triglyceride/Tg, HbA1c laboratory values and Tg/HDL ratio were examined. A statistically significant difference existed in the median uric acid values between the insulin-resistant and insulin-sensitive groups (P < .001). Additionally, a weak positive statistical correlation was identified between uric acid and HOMA-IR values (R = 0.299; P < .001) and uric acid and Tg/HDL values (R = 0.357; P < .001). This study concludes that there is a positive correlation between serum uric acid levels and insulin resistance.

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Assessing levels of uric acid and other cardiovascular markers in prehypertensive and hypertensive adults

da Cunha Agostini,

Cota e Souza,

Silva

et al. 2024

Hipertensión y Riesgo Vascular

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Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials

Cited by 3 publications

References 62 publications

Association between hyperuricemia and long-term mortality in patients with hypertension: results from the NHANES 2001–2018

Association between hyperuricemia and long-term mortality in patients with hypertension: results from the NHANES 2001–2018

What is the relationship between serum uric acid level and insulin resistance?: A case-control study

Assessing levels of uric acid and other cardiovascular markers in prehypertensive and hypertensive adults

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