Gender differences in prognostic factors for oral cancer

Honorato, J.; Rebelo, Marise Souto; Dias, Fernando Luiz; Camisasca, Danielle Resende; Faria, P.A.; Silva, G. Azevedo e; Lourenço, Simone de Queiroz Chaves

doi:10.1016/j.ijom.2015.04.015

Cited by 29 publications

(37 citation statements)

References 28 publications

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“…The same sample, however, showed significant differences in survival when current smokers were separated from past smokers (Figs. 2 and 5) with results similar to those of Bundgaard et al, 16 Honorato et al, 17 and Browman et al 14 In addition, when reformed smokers were split into two groups according to the duration of not smoking(>15 years and ≤15 years) the significance increased (0.029 to <0.01) (Fig. 3).…”

Section: Discussionsupporting

confidence: 81%

Reformed smokers have survival benefits after head and neck cancer

Cao

Liu

Gokavarapu

et al. 2016

British Journal of Oral and Maxillofacial Surgery

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Smoking tobacco is the main risk factor for head and neck cancer, is proportional to the number of pack years (number of packs smoked/day x number of years of smoking), and is reduced when the patient stops smoking. Current molecular evidence has suggested that tobacco-related cancers could be clinically more aggressive than cancers in non-smokers, particularly in the head and neck. However, clinical studies have not uniformly reproduced the relation between survival and tobacco, possibly because they ignore the health benefit that reformed smokers obtain during the period between giving up smoking and the diagnosis of cancer, which is not shared by those who continue to smoke and develop cancer. We have investigated the survival of reformed smokers, non-smokers, and continuing smokers after a diagnosis of head and neck cancer. The data of patients with head and neck cancer from 1992 -2013 from the Cancer Genome Atlas database were analysed using a multivariate Cox's regression model for survival, and Kaplan-Meier curves were produced for smoking history. A total of 521 patients were treated for head and neck cancer, and there was a significant difference in survival between reformed and non-smokers on the one hand, and current smokers on the other (p=0.02). The significance increased when reformed smokers were grouped according to their duration of abstinence and time of diagnosis of cancer (>15 and ≤15 years, p<0.01). Smoking history was a significant prognostic factor in the multivariate Cox's regression model when analysed with age, stage, grade, and site. We conclude that reformed smokers have a survival benefit in head and neck cancer.

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Section: Discussionsupporting

confidence: 81%

Reformed smokers have survival benefits after head and neck cancer

Cao

Liu

Gokavarapu

et al. 2016

British Journal of Oral and Maxillofacial Surgery

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“…The fact that women seek for medical oral healthcare more than men [9][10][11] , is confirmed in this paper as well. The most common diagnoses observed were benign lesions-cysts, masticatory myalgia-TMJ dysfunction, fractures and oral cavity infections.…”

Section: Discussionsupporting

confidence: 75%

Demographic characteristics, referrals and patients’ accessibility to an oral and maxillofacial surgery clinic

Veneti¹,

Stafylidis²,

Kafkia³

et al. 2017

Balkan J Dent Med

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Summary Background: Throughout the financial crisis in Greece, health expenditures have been significantly reduced. As a result, patients’ accessibility to various health care providers has been significantly reduced. The aim of the present study was to determine the profile of patients visiting a maxillofacial clinic in Northern Greece and the patients’ accessibility to the specific healthcare. Material and Methods: Data were collected from 481, out of the 600, patients visiting for the first time the University Maxillofacial Clinic of a hospital in Northern Greece during 2013 and 2014. The sample was called to answer to an anonymous self-reference questionnaire with questions regarding their demographic and clinical characteristics, the pattern of their referral to the specific clinic, their city of residence, as well as information regarding their hospitalization. Results: The majority of patients (53.4%) were referred by a physician, while 38.4% by a dentist. More than half (51.4%) were admitted to the specific clinic with admission diagnoses such as Benign Lesions-Cysts (25.2%), Masticatory Myalgia-Temporomandibular Joint Dysfunction (21.6%), Infections (19.5%) and Fractures (18%). The median time to seek to hospital evaluation/treatment, from the initial diagnosis, was 30 days. Nine out of ten patients stated that there was no Maxillofacial Surgery Clinic in their area of residence, while 80.3% reported using a private means of transport to access the clinic. Conclusions: The results indicated a delay with respect to the final diagnosis, as well as difficulty in patients’ accessibility, something that could contribute to an increase in morbidity and subsequently in the cost for managing patients’ maxillofacial problems.

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“…Even the rate of lymph node metastasis did not differ, suggesting that although women presented more superficial tumors, those findings were not associated with expressive lower regional metastasis rates. Other authors also observed similar results 6,10,11 . Interestingly, Chen et al also observed a higher prevalence of earlier stages among women, as well as an association between the presence of IL-6 tumor cytosolic, female gender and lymph node metastasis, demonstrating that other independent factors may also be involved in differences of metastasis risk between genders.…”

Section: Discussionsupporting

confidence: 73%

“…Recent studies suggest that the longer life expectancy among females and perhaps the later exposure to risk factors can collaborate with differences in age at onset of the disease in some regions 4 . Some authors observed a higher prevalence of early T stage among women 6,9,10 . Divergently, Kruse et al found no statistically significant differences in T and N stages between genders 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Although not included among the most incident malignancies of women in Brazil, about 28% of the new oral cavity cancers affect females in this country 5 . Although current literature still lacks a consensus, there is a trend towards a better prognosis among women with oral cavity cancer [1][2][3][4]6 . Prognostic variations observed between genders might be explained by clinical and pathological differences between men and women.…”

mentioning

confidence: 99%

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