Gender differences in pleural mesothelioma occurrence in Lombardy and Piedmont, Italy

Consonni, Dario; Migliore, Enrica; Barone-Adesi, Francesco; Dallari, Barbara; Matteis, Sara De; Oddone, Enrico; Pesatori, Angela Cecilia; Riboldi, Luciano; Mirabelli, Dario; Mensi, Carolina

doi:10.1016/j.envres.2019.108636

Cited by 3 publications

(3 citation statements)

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“…The application of advancement period methodology to mesothelioma has been very limited so far. Consonni et al 29 using data from Mesothelioma Registries of two large Italian regions compared men (more exposed) with women (less exposed) and estimated the advancement of incidence rates in the range from 7 years at age 45 to 11.5 years at age 75. Assuming that occupational asbestos exposure started on average at age 20 years, their results were not much different from ours but direct comparison is not possible given the absence of quantitative exposure estimates in their study.…”

Section: Discussionmentioning

confidence: 99%

“…The initial study base included 14 779 workers. Subjects without data on gender, date of birth and date of enrolment in the factory had been excluded from the cohorts at the beginning of the cohort formation 29. Two thousand two hundred one records were further excluded, for first employment after 1992 (approval of the asbestos ban in Italy), conflicting dates, incomplete working periods or unlikely age at hiring or end of employment.…”

Section: Methodsmentioning

confidence: 99%

“…That was a mathematical modelling exercise based on hypothetical values of RR applied to national mortality rates. Consonni et al 29 computed RAP by comparing mesothelioma incidence in men and women, on the assumption of different asbestos exposure in the average male (more exposed) and female (less exposed) populations. This assumption is fairly reasonable, but exposure could not be quantified.…”

Section: Introductionmentioning

confidence: 99%

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Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers

Azzolina

Consonni

Ferrante

et al. 2022

Thorax

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IntroductionExposure to asbestos increases the risk of lung cancer and mesothelioma. Few studies quantified the premature occurrence of these diseases in asbestos-exposed workers. Focus on premature disease onset (rate advancement or acceleration) can be useful in risk communication and for the evaluation of exposure impact. We estimated rate advancement for total mortality, lung cancer and pleural mesothelioma deaths, by classes of cumulative asbestos exposure in a pooled cohort of asbestos cement (AC) workers in Italy.MethodThe cohort study included 12 578 workers from 21 cohorts, with 6626 deaths in total, 858 deaths from lung cancer and 394 from pleural malignant neoplasm (MN). Rate advancement was estimated by fitting a competitive mortality Weibull model to the hazard of death over time since first exposure (TSFE).ResultAcceleration time (AT) was estimated at different TSFE values. The highest level of cumulative exposure compared with the lowest, for pleural MN AT was 16.9 (95% CI 14.9 to 19.2) and 33.8 (95% CI 29.8 to 38.4) years at TSFE of 20 and 40 years, respectively. For lung cancer, it was 13.3 (95% CI 12.0 to 14.7) and 26.6 (95% CI 23.9 to 29.4) years, respectively. As for total mortality, AT was 3.35 (95% CI 2.98 to 3.71) years at 20 years TSFE, and 6.70 (95% CI 5.95 to 7.41) at 40 years TSFE.ConclusionThe current study observed marked rate advancement after asbestos exposure for lung cancer and pleural mesothelioma, as well as for total mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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