Gender Differences in Perceptions of Urge To Cough and Dyspnea Induced by Citric Acid in Healthy Never Smokers

Gui, Peijun; Ebihara, Satoru; Kanezaki, Masashi; Suda, Chihiro; Nikkuni, Etsuhiro; Ebihara, Takae; Yamasaki, Makari; Kohzuki, Masahiro

doi:10.1378/chest.10-0588

Cited by 24 publications

(31 citation statements)

References 43 publications

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“…It has been shown that inspiratory muscle strength is significantly greater in men than women with asthma, and is inversely related to dyspnea 8 . Similarly, in healthy female nonsmokers, women demonstrate a lower cough reflex threshold associated with a greater urge to cough and a greater sense of dyspnea when compared to males 32 . Finally, it is possible that factors such as pre-menstrual worsening of asthma 33–35 or increased anxiety and depression in women with asthma 36 which were not easily accounted for in this analysis could explain some of the sex-related differences we identified.…”

Section: Discussionmentioning

confidence: 94%

Sex differences in asthma symptom profiles and control in the American Lung Association Asthma Clinical Research Centers

McCallister

Holbrook

Wei

et al. 2013

Respiratory Medicine

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Objective Important differences between men and women with asthma have been demonstrated, with women describing more symptoms and worse asthma-related quality of life (QOL) despite having similar or better pulmonary function. While current guidelines focus heavily on assessing asthma control, they lack information about whether sex-specific approaches to asthma assessment should be considered. We sought to determine if sex differences in asthma control or symptom profiles exist in the well-characterized population of participants in the American Lung Association Asthma Clinical Research Centers (ALA-ACRC) trials. Methods We reviewed baseline data from four trials published by the ALA-ACRC to evaluate individual item responses to three standardized asthma questionnaires: the Juniper Asthma Control Questionnaire (ACQ), the multi-attribute Asthma Symptom Utility Index (ASUI), and Juniper Mini Asthma Quality of Life Questionnaire (mini-AQLQ). Results In the poorly-controlled population, women reported similar overall asthma control (mean ACQ 1.9 vs. 1.8; p=0.54), but were more likely to report specific symptoms such as nocturnal awakenings, activity limitations, and shortness of breath on individual item responses. Women reported worse asthma-related QOL on the mini-AQLQ (mean 4.5 vs. 4.9; p<0.001) and more asthma-related symptoms with a lower mean score on the ASUI (0.73 vs. 0.77; p=<0.0001) and were more likely to report feeling bothered by particular symptoms such as coughing, or environmental triggers. Conclusions In participants with poorly-controlled asthma, women had outwardly similar asthma control, but had unique symptom profiles on detailed item analyses which were evident on evaluation of three standardized asthma questionnaires.

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Section: Discussionmentioning

confidence: 94%

Sex differences in asthma symptom profiles and control in the American Lung Association Asthma Clinical Research Centers

McCallister

Holbrook

Wei

et al. 2013

Respiratory Medicine

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“…Del mismo modo, la población adulta mayor tiene una prevalencia más alta de enfermedades crónicas respiratorias que puede influir en la expresión del síntoma, este hecho, podría ser una explicación adicional, de que en nuestros resultados se encuentra una frecuencia relativamente más alta de disnea cuando se divide por edad en menores y mayores de 60 años. En estudios previos la disnea es reportada más frecuentemente en el sexo femenino (17,18), nuestros resultados muestran esta tendencia con un número mayor de mujeres que refieren el síntoma, sin embargo, el número de pacientes evaluados en este estudio no es suficiente para detectar diferencias definitivas en lo relacionado al sexo.…”

Section: Discussionunclassified

Prevalencia de síntomas respiratorios y riesgo de obstrucción al flujo aéreo en Ginebra - Valle del Cauca

et al. 2017

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RESUMENAntecedentes y Objetivo: La prevalencia de los principales síntomas respiratorios en Ginebra (Valle del Cauca) es desconocida. Este estudio busca investigar la prevalencia de disnea, tos, sibilancias y expectoración en Ginebra, un municipio rural de Colombia.Métodos: Se realizó un estudio de corte transversal, con una estrategia de muestreo por conglomerados para tener una muestra representativa de adultos mayores de 40 años. Cada paciente fue entrevistado con dos cuestionarios, el cuestionario de síntomas respiratorios Ferris validado para el español y el cuestionario de función pulmonar (LFQ), de este último, un puntaje menor o igual a 18 puntos fue considerado como riesgo de obstrucción al flujo aéreo. El análisis de datos fue realizado con software estadístico, el tamaño de muestra fue de 115 sujetos (prevalencia 50%, precisión 10% y porcentaje de pérdida del 20%), las variables cuantitativas se resumieron en frecuencias y porcentajes y las variables cuantitativas en medianas y rangos intercuartílicos, la prevalencia de síntomas respiratorios se calculó con un intervalo de confianza del 95% y se realizaron cruces exploratorios entre las variables de síntomas respiratorios y antecedentes exposicionales.Resultados: 146 sujetos, 2 pérdidas, mediana de edad 60,5 años (RIQ:22), 52,1% hombres, prevalencia de tos 18,1% (IC95%:11,8-24,3), expectoración 20,1% (IC95%:13,9-27,1), sibilancias 28,2% (IC95%:21,1-35,9), disnea 33,3% (IC95%:25-41), personas a riesgo de limitación flujo aéreo 19,4% (IC95%:14,2-28,4). En la realización de cruces exploratorios se obtuvo una relación entre el número de paquetes año y la presencia de tos (p=0,008), an- Conclusión: La disnea es el síntoma respiratorio más frecuente en pacientes mayores de 40 años en Ginebra (Valle del Cauca), el antecedente de tabaquismo se relacionó con tos y sibilancias. La utilización de un cuestionario de sínto-mas respiratorios puede ser útil para identificar pacientes con riesgo de obstrucción al flujo aéreo cuando se compara con el auto-reporte de enfermedad respiratoria.Palabras clave: Signos y síntomas respiratorios; Tos; Disnea; Test de función respiratoria; Prevalencia. PREVALENCE OF RESPIRATORY SYMPTOMS AND RISK OF OBSTRUCTION TO AIR FLOW IN GINEBRA -VALLE DEL CAUCA.ABSTRACT Background and objective: The prevalence of main respiratory symptoms in Ginebra (Valle del Cauca) is unknown. This study aimed to investigate dyspnea, cough, wheezes and expectoration in Ginebra a Town of Colombia. Methods:A cross-sectional design and a random, conglomerates-sampling strategy were used to provide representative samples of adults aged > 40 years. Each participant was interviewed with two questionnaires, validated Spanish version of the Ferris Respiratory Questionnaire and Lung Function Questionnaire (LFQ), of the latter, and a score less or equal 18 points was considered with risk of obstructive airflow. Analysis was performed using statistical software, sample size of 115 subjects (prevalence 50%, precision 10% and lost percentage 20%), the variables quant...

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“…For instance, the slope of the response function is steeper in women than men, but the Cu does not differ between the sexes Gui et al, 2010). The Cu is also comparable among smokers and non-smokers, although smoking is associated with a decrease in the slope of the urge-tocough stimulus-response function (Kanezaki et al, 2012, which trends towards normal levels when smoking is ceased (Dicpinigaitis et al, 2006).…”

Section: Sensory Attributes Of the Urge-to-coughmentioning

confidence: 92%

Sensations and regional brain responses evoked by tussive stimulation of the airways

Farrell

Mazzone

2014

Respiratory Physiology & Neurobiology

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Gender Differences in Perceptions of Urge To Cough and Dyspnea Induced by Citric Acid in Healthy Never Smokers

Cited by 24 publications

References 43 publications

Sex differences in asthma symptom profiles and control in the American Lung Association Asthma Clinical Research Centers

Sex differences in asthma symptom profiles and control in the American Lung Association Asthma Clinical Research Centers

Prevalencia de síntomas respiratorios y riesgo de obstrucción al flujo aéreo en Ginebra - Valle del Cauca

Sensations and regional brain responses evoked by tussive stimulation of the airways

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