Gender differences in patients with acute ST-elevation myocardial infarction complicated by cardiogenic shock

Koeth, Oliver; Zahn, Ralf; Heer, Tobias; Bauer, Timm; Juenger, Claus; Klein, Bärbel; Gitt, Anselm K.; Senges, Jochen; Zeymer, Uwe

doi:10.1007/s00392-009-0080-7

Cited by 49 publications

(28 citation statements)

References 34 publications

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“…11,12,19 The influence of these disease-dependent parameters on mortality was similar in men and women. In agreement with other data, a low EF as well as hemodynamic instability were associated with a higher mortality.…”

Section: Discussionmentioning

confidence: 89%

Gender‐Related Differences in Patients With ST‐Elevation Myocardial Infarction: Results From the Registry Study of the ST Elevation Myocardial Infarction Network Essen

Hailer¹,

Naber

Koslowski³

et al. 2011

Clinical Cardiology

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Background:The Myocardial Infarction Network Essen was initiated in order to establish a standardized procedure with immediate reopening of the infarcted vessel for patients with ST-elevation myocardial infarction (STEMI) in the city of Essen, Germany. The present study aims to evaluate gender-related differences in presentation of disease and clinical outcome. Hypothesis: Gender is associated with differences in presentation and outcome of STEMI. Methods: All patients with STEMI were included without exception. Parameters such as risk profile, mortality, and relevant time intervals were documented. The follow-up period was 1 year. Results: For this study, 1365 patients (72.1% male) were recruited. Women were significantly older, with higher prevalence of diabetes (28.1% vs 20.3%, P = 0.004) and hypertension (76.5% vs 64.8%, P < 0.0005). Analysis of time intervals between symptoms to actions showed no significant differences. However, women tended to wait longer before calling for medical assistance (358 vs 331 min, P = 0.091). In-hospital mortality was comparable with respect to gender, whereas women had higher 1-year mortality (18.6% vs 13.2%). Age and diabetes were associated with a higher mortality. Adjusted for age, gender is no longer an independent risk factor. In the follow-up period, significantly more women were readmitted to the hospital without a difference in the frequency of reangiography, surgery, or target-vessel revascularization. Conclusions: The present data display a successful implementation of a standardized procedure in patients with STEMI. Although differences between genders are not as obvious as expected, efforts should be taken to perform a gender-specific risk analysis as well as to promote education about proper behavior in case of new onset of angina. IntroductionAlthough gender-related differences in treatment and prognosis of acute myocardial infarction (MI) have been documented for more than a decade, the results are still conflicting. Some investigations have described a generally consistent pattern of less-intensive treatment in acute MI

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Section: Discussionmentioning

confidence: 89%

Gender‐Related Differences in Patients With ST‐Elevation Myocardial Infarction: Results From the Registry Study of the ST Elevation Myocardial Infarction Network Essen

Hailer¹,

Naber

Koslowski³

et al. 2011

Clinical Cardiology

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“…Men and women with AMI are known to have a different clinical presentation and outcome [15][16][17][18][19][20] but currently there is little information about gender-related differences in the clinical profile of TTC. 21,22 PATHOPHYSIOLOGIC BACKGROUND The precise pathophysiology of TTC is still not well understood.…”

Section: Introductionmentioning

confidence: 98%

Gender-Related Differences in Takotsubo Cardiomyopathy

Athanasiadis

Sechtem

2013

Heart Failure Clinics

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“…anifestations and outcomes of disease, including cardiovascular conditions, [1][2][3][4] immune disease, 5,6 respiratory illness [6][7][8] and mental health conditions, 9,10 have long been known to differ between men and women. These differences relate to sex (molecular, cellular and epigenetic mechanisms of male and female physiology) and gender (adopted or imposed social norms, behaviours, identities and expectations).…”

mentioning

confidence: 99%

Sex and gender considerations in Canadian clinical practice guidelines: a systematic review

et al. 2017

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Background:The importance of sex and gender in the diagnosis and management of health conditions is well established, but the extent to which this evidence is integrated into clinical practice guidelines remains unknown. We aimed to determine the proportion of Canadian clinical practice guidelines that integrate evidence on sex and gender considerations. Methods:We searched the Canadian Medical Association's CPG Infobase, PubMed, all provincial/territorial websites and websites of professional organizations for English-and French-language Canadian clinical practice guidelines published between January 2013 and June 2015 on selected conditions identified as priorities by policy-makers and practitioners. Citations and text were searched electronically using keyword terms related to sex and gender. Three investigators independently analyzed and categorized the content of text-positive clinical practice guidelines based on clinical relevance for practitioners. Results:Of the 118 clinical practice guidelines that met the inclusion criteria, 79 (66.9%) were text-positive for sex and/or gender keywords; 8 (10%) of the 79 used the keywords only in relation to pregnancy. Of the remaining 71 guidelines, 25 (35%) contained sex-related diagnostic or management recommendations. An additional 5 (7%) contained recommendations for sex-specific laboratory reference values, 29 (41%) referred to differences in epidemiologic features or risk factors only, and 12 (17%) contained nonrelevant mentions of search keywords. Twenty-five (35%) of the text-positive guidelines used the terms "sex" and/or "gender" correctly. higher in women than in men, with increased risk of driving impairment. 19 Rochon and colleagues 20 discovered that, in Ontario, men with dementia who were prescribed antipsychotic drugs had significantly higher risks for hospital admission and death than did women with dementia. Similarly, social risk factors are associated with higher rates of suicide in older men, which suggests that more aggressive screening and treatment may be required. [21][22][23] The extent to which evidence about sex and gender is integrated into clinical practice guidelines for diagnosis and management of diseases remains unknown. We conducted a systematic review to investigate the integration of sex and gender evidence into Canadian clinical practice guidelines published between 2013 and 2015 for noncommunicable health conditions. Methods Data sources and inclusion criteriaProtocols for this review are posted on Open Science Framework and follow PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) reporting guidelines (www.prisma-statement.org/). The review search focused on selected health conditions identified as priorities by policymakers and practitioners [24][25][26][27][28][29][30] (Box 1). We considered only 2 cancers, lung and colorectal, because they are among the leading causes of death from cancer for both females and males, 31 and important sex and/or gender differences in prevalence, risk and screening, path...

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Gender differences in patients with acute ST-elevation myocardial infarction complicated by cardiogenic shock

Cited by 49 publications

References 34 publications

Gender‐Related Differences in Patients With ST‐Elevation Myocardial Infarction: Results From the Registry Study of the ST Elevation Myocardial Infarction Network Essen

Gender‐Related Differences in Patients With ST‐Elevation Myocardial Infarction: Results From the Registry Study of the ST Elevation Myocardial Infarction Network Essen

Gender-Related Differences in Takotsubo Cardiomyopathy

Sex and gender considerations in Canadian clinical practice guidelines: a systematic review

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