Gender Differences in Outcomes of Cirrhosis in a Large Cohort of Patients in the United States

Yeluru, Apurva; Nguyen, Pauline; Le, An K.; Zhao, Changqing; Hoang, Joseph; Yasukawa, Lee Ann; Weber, Susan C.; Nguyen, Mindie H.

doi:10.1016/s0016-5085(17)33835-0

Cited by 2 publications

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“…In comparison with most men who had a more sedentary lifestyle [67][68][69][70], adult women under the age of 65 who were reported more doctor visits and go to gym more often than men, with the gender difference widest among individuals aged 18-44 [71]. Moreover, men who drink more alcohol and more smoking than women [72] were 4.5 times as likely to die from CHD in middle age [73] and twice from cirrhosis [74,75] and more vulnerable to respiratory illnesses, such as COPD and lung cancer, and had more excess risk of death from these diseases.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the association between marital status and the risk of cardiovascular, cancer, and all-cause mortality: a systematic review and meta-analysis of 7,881,040 individuals

Wang

Jiao

Nie

et al. 2020

glob health res policy

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Purpose: To ascertain whether sex differences exist in the relationship between marital status and cardiovascular diseases (CVD), coronary heart disease (CHD), cancer and all-cause mortality in the general population and to explore the potential effect of age, location, the duration of follow-up and publication years on these outcomes. Methods: A systematic search was performed in PubMed and EMBASE from inception through to April 2018 and review of references to obtain sex-specific relative risks and their 95% confidence intervals. These were used to derive the women-to-men ratio of RRs (RRR) and 95% CI for each study. RRs and RRRs for each outcome were then pooled using random effects inverse-variance weighted meta-analysis. Results: Twenty-one studies with 7,891,623 individuals and 1,888,752 deaths were included in the meta-analysis. Compared with married individuals, being unmarried was significantly associated with all-cause, cancer, CVD and coronary heart disease mortalities for both sexes. However, the association with CVD and all-cause mortality was stronger in men. Being divorced/separated was associated with a higher risk of all-cause mortality in men and a stronger risk of cancer and CVD mortality. The pooled ratio for women versus men showed 31 and 9% greater risk of stroke mortality and all-cause mortality associated with never married in men than in women. Conclusions: Being unmarried conferred higher risk of stroke and all-cause mortality for men than women. Moreover, divorced/separated men had higher risk of cancer mortality and CVD mortality. Further studies are warranted to clarify the biological, behavioral, and/or social mechanisms involved in sex differences by these associations.

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Section: Discussionmentioning

confidence: 99%

Sex differences in the association between marital status and the risk of cardiovascular, cancer, and all-cause mortality: a systematic review and meta-analysis of 7,881,040 individuals

Wang

Jiao

Nie

et al. 2020

glob health res policy

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“…[ 9 ] Among patients with cirrhosis, females have better outcome than males in terms of HCC incidence and overall survival. [ 11 ] Consistently, the genetic content in hepatitis B virus (HBV)–related HCC was found to be different between the two sexes in terms of copy number variation. [ 12 ] Hence, it is plausible that genetic events in CLD could be sex‐specific throughout the multistep process.…”

Section: Introductionmentioning

confidence: 99%

Sex‐specific analysis of microRNA profiles in HBV‐associated cirrhosis by small RNA‐sequencing

Chan

Fung

et al. 2022

Hepatol Commun

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Liver cirrhosis represents an advanced stage of chronic liver disease and is associated with significant morbidity, mortality, and risk of cancer development. While sex disparity of liver diseases has been observed, understanding at a genetic level awaits more thorough investigation. In this study, we performed a sex‐specific analysis of the microRNA (miR) profiles in hepatitis B virus (HBV)–associated cirrhosis by small RNA‐sequencing using clinical tissue samples. Potential associated signaling pathways, downstream gene targets, and upstream regulators were highlighted by computational prediction analyses based on the differentially expressed miRs (DEmiRs). From our results, deregulation of miRs in cirrhosis showed a marked difference between males and females by the degree and pattern. Sixty‐five (64 up‐regulated, 1 down‐regulated) and 12 (6 up‐regulated, 6 down‐regulated) DEmiRs were found in males and females, respectively, when compared with their respective control group. A number of DEmiRs were only observed in one sex but not the other. In addition, 26 DEmiRs were identified between cirrhosis female and cirrhosis male groups. Fatty acid biosynthesis pathway, extracellular matrix–receptor interaction, p53 signaling, Hippo signaling, tumor necrosis factor signaling, the forkhead box O signaling, as well as gene targets ribosomal protein S27 like, methyl CpG binding protein 2, and estrogen receptor 1, may contribute to the pathogenesis and biological behavior of cirrhosis in a sex‐specific manner. Analysis of the Cancer Genome Atlas data set suggested a role of sex‐specific DEmiRs in multistep hepatocarcinogenesis. Conclusion: Our findings illustrate that miR profiles in HBV‐associated cirrhosis are distinct between the males and females and suggest a potential role of sex‐specific biomarkers and molecular mechanisms in disease development and progression.

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Gender Differences in Outcomes of Cirrhosis in a Large Cohort of Patients in the United States

Cited by 2 publications

References 0 publications

Sex differences in the association between marital status and the risk of cardiovascular, cancer, and all-cause mortality: a systematic review and meta-analysis of 7,881,040 individuals

Sex differences in the association between marital status and the risk of cardiovascular, cancer, and all-cause mortality: a systematic review and meta-analysis of 7,881,040 individuals

Sex‐specific analysis of microRNA profiles in HBV‐associated cirrhosis by small RNA‐sequencing

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