“…The sexrelated differences that are seen after cardiovascular surgery may be related to a sex-specific clustering of preoperative characteristics. 2 Considering the impact of preoperative characteristics, especially serious conditions, on operative mortality risk for patients with ATAAD, generalized ischemia (shock or hypotension), 3,4 critical organ-specific ischemias (ie, mesentery, coronary, and cerebral ischemias), [5][6][7] and cardiac tamponade 8 have been repeatedly demonstrated as independent predictors of operative mortality by a number of investigators. As Fukui and colleagues 1 pointed out, there was only a single study dealing with sex-related differences in patients undergoing repaired ATAAD, which used data from the International Registry of Acute Aortic Dissection.…”