Gender differences in lipoprotein metabolism and dietary response: Basis in hormonal differences and implications for cardiovascular disease

Knopp, Robert H.; Paramsothy, Pathmaja; Retzlaff, Barbara M.; Fish, Brian; Walden, Carolyn E.; Dowdy, Alice; Tsunehara, Christine H.; Aikawa, Kohsuke; Cheung, Marian C.

doi:10.1007/s11883-005-0065-6

Cited by 123 publications

(84 citation statements)

References 46 publications

(47 reference statements)

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“…Futhermore, the nutritional transition that is on-going in developing world has greater impact on obesity among women. This is due to differences in carbohydrate metabolism between males and females (Knopp et al, 2005). Finally, biological factor such as menopause may contribute to higher prevalence of obesity in the females in this study.…”

Section: Prevalence Of Obesitymentioning

confidence: 73%

High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention

Raimi¹,

Odusan²,

Fasanmade³

2015

J. Diabetes Endocrinol.

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Obesity has reached epidemic proportions globally, and is now prevalent in low-income and middleincome countries. This study sets out to determine the prevalence of obesity as well as its predictors in rural South-Western Nigeria. Cross-sectional descriptive survey of 416 participants aged 20 to 70 years in two rural communities in Remo North Local Government area of Ogun State, Nigeria was taken. Relevant clinical and demographic parameters were obtained. Participants were screened for generalized and central obesity, using standard protocol. The prevalence of overweight and generalized obesity was 21.4 and 10.5%, respectively in all the participants. Females had a higher frequency of generalized obesity than the males (p<0.001). Central obesity was significantly more prevalent among the female participants with three different criteria (p≤0.001). More participants were classified as centrally obese using waist-to-hip ratio (WHR) or waist-to-height ratio (WHtR) than waist circumference (WC). Predictors of central obesity were age, female gender, alcohol and cigarette smoking. The prevalence of obesity is high in rural communities of South-Western Nigeria. Compared to men, the chances of developing central obesity (defined as increased WC) increased by 11-fold among the women. Targeted aggressive healthy lifestyle intervention becomes necessary to prevent future cardiovascular disease.

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Section: Prevalence Of Obesitymentioning

confidence: 73%

High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention

Raimi¹,

Odusan²,

Fasanmade³

2015

J. Diabetes Endocrinol.

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“…The gender differences may be related to the faster transport of lipids in the bloodstream of women compared with men in the blood stream, earlier age-graded serum cholesterol changes in women, and higher concentrations of cholesterol in elderly women than men (53)(54)(55). However, our results underscored the importance of keeping cholesterol concentration within the high normal range, although a longitudinal follow-up is needed to determine whether higher cholesterol prevents later life cognitive impairment in both men and women.…”

Section: Discussionmentioning

confidence: 99%

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Yin

Chei

et al. 2016

The Journal of nutrition, health and aging

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Objectives-The association between cognitive function and cholesterol levels is poorly understood and inconsistent results exist among the elderly. The purpose of this study is to investigate the association of cholesterol level with cognitive performance among Chinese elderly.Design-A cross-sectional study was implemented in 2012 and data were analyzed using generalized additive models, linear regression models and logistic regression models. Conflict of interestThe authors declare that there are no conflicts of interests. Ethical standardsThe authors declare that all the experiments of this study complied with the current laws of China in which they were performed. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptSetting-Community-based setting in eight longevity areas in China.Subjects-A total of 2000 elderly aged 65 years and over (mean 85.8±12.0 years) participated in this study. Measurements-Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) concentration were determined and cognitive impairment was defined as Mini-Mental State Examination (MMSE) score≤23.Results-There was a significant positive linear association between TC, TG, LDL-C, HDL-C and MMSE score in linear regression models. Each 1 mmol/L increase in TC, TG, LDL-C and HDL-C corresponded to a decreased risk of cognitive impairment in logistic regression models. Compared with the lowest tertile, the highest tertile of TC, LDL-C and HDL-C had a lower risk of cognitive impairment. The adjusted odds ratios and 95% CI were 0.73(0.62-0.84) for TC, 0.81(0.70-0.94) for LDL-C and 0.81(0.70-0.94) for HDL-C. There was no gender difference in the protective effects of high TC and LDL-C levels on cognitive impairment. However, for high HDL-C levels the effect was only observed in women. High TC, LDL-C and HDL-C levels were associated with lower risk of cognitive impairment in the oldest old (aged 80 and older), but not in the younger elderly (aged 65 to 79 years).Conclusions-These findings suggest that cholesterol levels within the high normal range are associated with better cognitive performance in Chinese elderly, specifically in the oldest old. With further validation, low cholesterol may serve a clinical indicator of risk for cognitive impairment in the elderly.

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“…The three loci in males were located on chromosome 1q42.3 ( P = 0.001 for fatty liver), 7p12-21 ( P = 0.0002 for log ALT), and 22p13-q11 ( P = 0.0007 for fatty liver). The lack of association in females was ascribed to the heterogeneous female population in terms of menopausal status, together with the well-known effects of estrogens on lipid and liver metabolism ( 49 ).…”

Section: Impaired Hepatic Triglyceride Exportmentioning

confidence: 99%

Genetic determinants of hepatic steatosis in man

Hooper

Adams

Burnett

2011

Journal of Lipid Research

115

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in childhood in some individuals, with a prevalence of 10% found in an autopsy study of 2-19 year olds from the United States ( 5 ). The prevalence of NAFLD increases with advancing age, with a peak between 40 and 69 years of age ( 2, 6 ).A cut-off of 5.5% hepatic steatosis has been accepted as the threshold to diagnose fatty liver, based on the 95th centile of hepatic fat content in low-risk subjects [normal body mass index (BMI), normal glucose tolerance, lack of excessive alcohol ingestion, and normal liver function tests] ( 1, 7 ). Subjects with NAFLD may have a range of histopathological changes (

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Gender differences in lipoprotein metabolism and dietary response: Basis in hormonal differences and implications for cardiovascular disease

Cited by 123 publications

References 46 publications

High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention

High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Genetic determinants of hepatic steatosis in man

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