Gender Differences in Electrophysiologic Effects of Mental Stress and Autonomic Tone Inhibition:

Insulander, Per; Vallin, Hans

doi:10.1046/j.1540-8167.2005.04117.x

Cited by 26 publications

(24 citation statements)

References 39 publications

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“…Indeed, we found only one other study that performed invasive diagnostic electrophysiology evaluation in 23 healthy volunteers. 23 That study also included placement of an intra-arterial catheter for blood pressure monitoring, and the authors did not report on any complications.…”

Section: Discussionmentioning

confidence: 99%

MK-0448, a Specific Kv1.5 Inhibitor

Pavri

Greenberg

Kraft

et al. 2012

Circ: Arrhythmia and Electrophysiology

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Background-We evaluated the viability of I Kur as a target for maintenance of sinus rhythm in patients with a history of atrial fibrillation through the testing of MK-0448, a novel I Kur inhibitor. Methods and Results-In vitro MK-0448 studies demonstrated strong inhibition of I Kur with minimal off-target activity. In vivo MK-0448 studies in normal anesthetized dogs demonstrated significant prolongation of the atrial refractory period compared with vehicle controls without affecting the ventricular refractory period. In studies of a conscious dog heart failure model, sustained atrial fibrillation was terminated with bolus intravenous MK-0448 doses of 0.03 and 0.1 mg/kg. These data led to a 2-part first-in-human study: Part I evaluated safety and pharmacokinetics, and part II was an invasive electrophysiological study in healthy subjects. MK-0448 was well-tolerated with mild adverse experiences, most commonly irritation at the injection site. During the electrophysiological study, ascending doses of MK-0448 were administered, but no increases in atrial or ventricular refractoriness were detected, despite achieving plasma concentrations in excess of 2 μmol/L. Follow-up studies in normal anesthetized dogs designed to assess the influence of autonomic tone demonstrated that prolongation of atrial refractoriness with MK-0448 was markedly attenuated in the presence of vagal nerve simulation, suggesting that the effects of I Kur blockade on atrial repolarization may be negated by enhanced parasympathetic neural tone. Conclusions-The contribution of I Kur to human atrial electrophysiology is less prominent than in preclinical models and therefore is likely to be of limited therapeutic value for the prevention of atrial fibrillation. (Circ Arrhythm Electrophysiol. 2012;5:1193-1201.)

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Section: Discussionmentioning

confidence: 99%

MK-0448, a Specific Kv1.5 Inhibitor

Pavri

Greenberg

Kraft

et al. 2012

Circ: Arrhythmia and Electrophysiology

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“…Women who develop PTSD often experienced numerous traumatic events in life (mean (Gill, Page, Sharps, & Campbell, 2008;Holbrook et al, 2002) and are at risk of repeatedly re-experiencing traumatic events through flashbacks, intrusive thoughts, and dreams (Gill, Saligan, Henderson, & Szanton, 2009; United States Department of Veterans Affairs [US Department of Veteran Affairs], 2010a) with potential for additional impact on autonomic tone (Cohen, Benjamin, et al, 2000). Stress had a greater effect on the sinus and atrioventricular nodes in women (Insulander & Vallin, 2005), and women exhibited greater cardiac response with repeated stress than men (Schmaus et al, 2008).…”

Section: Response Of Women's Hearts To Stressmentioning

confidence: 99%

“…In a study of 50 healthy men and women, short term acute laboratory stress from having to give a speech initially increased heart rate (p < .001), LF (p < .001), and HF (p = .019) but geometric changes were more associated with chronic hassle stressors (r = -.35, p = .019) (Schubert et al, 2009). While undergoing ECG and hemodynamic monitoring during separate testing from word-conflict exercises, atropine, and propranolol, women (n = 12) displayed more effect on the sinus (p < .05) and AV (p < .01) nodes than men (n = 11) with refractory and conduction time decreased during stress (Insulander & Vallin, 2005). Overall, laboratory induced stress increased sympathetic and decreased parasympathetic activity on the heart when measured during pharmacologic blockade; however, there were notable differences in individual response (n = 10) (Berntson et al, 1994).…”

Section: Chronic and Acute Distressmentioning

confidence: 99%

“…Women exhibit greater reactivity at the sinus and AV nodes than men (Insulander & Vallin, 2005) and may be more vulnerable to exaggerated autonomic response with repeated stress exposure (Schmaus et al, 2008). MST may evoke intense feelings of fear of recurrent attacks, anger over betrayal by a fellow teammate, and isolation from peers.…”

Section: Recommendations For Clinical Practicementioning

confidence: 99%

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Military Sexual Trauma Exposure and Heart Rate Variability Outcomes in Female Veterans

Lee¹

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DEDICATIONThis dissertation is dedicated to God, who opened my eyes, ears and heart to the abuse and suffering of women everywhere, including my Aunt Ethel who suffered at the hands of her husband when I was a child; my friend and former nursing student Micah, who died from her injuries; and all those abused that I cared for in numerous hospitals, clinics, and shelters through the years. I want to especially acknowledge the sacrifice made by the veterans who experienced military sexual trauma while serving our country.iv ACKNOWLEDGEMENTS

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“…30 However, mental stress may modulate this effect. 31,32 Whether this modulation effect is valid in the context of online gaming is worth further investigation. Hence, this research explores the following hypotheses from the ANS perspective: …”

Section: Introductionmentioning

confidence: 99%

Effects of Gender and Game Type on Autonomic Nervous System Physiological Parameters in Long-Hour Online Game Players

Lin

2013

Cyberpsychology, Behavior, and Social Networking

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Online game playing may induce physiological effects. However, the physical mechanisms that cause these effects remain unclear. The purpose of this study was to examine the physiological effects of long-hour online gaming from an autonomic nervous system (ANS) perspective. Heart rate variability (HRV), a valid and noninvasive electrocardiographic method widely used to investigate ANS balance, was used to measure physiological effect parameters. This study used a five-time, repeated measures, mixed factorial design. Results found that playing violent games causes significantly higher sympathetic activity and diastolic blood pressure than playing nonviolent games. Long-hour online game playing resulted in the gradual dominance of the parasympathetic nervous system due to physical exhaustion. Gaming workload was found to modulate the gender effects, with males registering significantly higher sympathetic activity and females significantly higher parasympathetic activity in the higher gaming workload group.

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Gender Differences in Electrophysiologic Effects of Mental Stress and Autonomic Tone Inhibition:

Cited by 26 publications

References 39 publications

MK-0448, a Specific Kv1.5 Inhibitor

MK-0448, a Specific Kv1.5 Inhibitor

Military Sexual Trauma Exposure and Heart Rate Variability Outcomes in Female Veterans

Effects of Gender and Game Type on Autonomic Nervous System Physiological Parameters in Long-Hour Online Game Players

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