Gender differences in arterial structure and function. Are men really from Mars and women from Venus?

Mattace-Raso, Francesco

doi:10.1016/j.artres.2009.10.186

Cited by 3 publications

(5 citation statements)

References 22 publications

(21 reference statements)

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“…Fourth, with respect to gender difference in arterial stiffness, the authors are aware of the controversial reports about this interesting issue [9, 30]. In our study, there were no statistically significant differences in PWV values linked to gender.…”

Section: Discussioncontrasting

confidence: 45%

Reference Values of Pulse Wave Velocity in Healthy People from an Urban and Rural Argentinean Population

Diaz

Galli

Tringler

et al. 2014

International Journal of Hypertension

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In medical practice the reference values of arterial stiffness came from multicenter registries obtained in Asia, USA, Australia and Europe. Pulse wave velocity (PWV) is the gold standard method for arterial stiffness quantification; however, in South America, there are few population-based studies. In this research PWV was measured in healthy asymptomatic and normotensive subjects without history of hypertension in first-degree relatives. Normal PWV and the 95% confidence intervals values were obtained in 780 subjects (39.8 ± 18.5 years) divided into 7 age groups (10–98 years). The mean PWV found was 6.84 m/s ± 1.65. PWV increases linearly with aging with a high degree of correlation (r 2 = 0.61; P < 0.05) with low dispersion in younger subjects. PWV progressively increases 6–8% with each decade of life; this tendency is more pronounced after 50 years. A significant increase of PWV over 50 years was demonstrated. This is the first population-based study from urban and rural people of Argentina that provides normal values of the PWV in healthy, normotensive subjects without family history of hypertension. Moreover, the age dependence of PWV values was confirmed.

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Section: Discussioncontrasting

confidence: 45%

Reference Values of Pulse Wave Velocity in Healthy People from an Urban and Rural Argentinean Population

Diaz

Galli

Tringler

et al. 2014

International Journal of Hypertension

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“…34 Gender difference in AS is one of the most controversial and still unsolved issues in CV disease. 12,35 In our study, there was no difference in PWV values linked to gender, in accordance to large population based studies, in which gender difference in PWV was null or had no clinical significance (<0.1 m/s). 24,34,36,37 Moreover, in the framework of the Anglo Cardiff Collaborative Study and Multi Ethnic Study of Atherosclerosis, 34 gender had no effect on the stiffness of large arteries and PWV, and Cecelja et al also reported lack of association of PWV and gender.…”

Section: Discussionsupporting

confidence: 90%

“…Gender difference in AS is one of the most controversial and still unsolved issues in CV disease . In our study, there was no difference in PWV values linked to gender, in accordance to large population based studies, in which gender difference in PWV was null or had no clinical significance (<0.1 m/s) .…”

Section: Discussionsupporting

confidence: 88%

The effects of age on pulse wave velocity in untreated hypertension

Diaz

Tringler

Wray

et al. 2017

J of Clinical Hypertension

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Increased arterial stiffness is an important determinant of cardiovascular risk, able to predict morbidity and mortality, and closely associated with ageing and blood pressure. The aims of this study were: (1) To determine the age-dependent reference pulse wave velocity (PWV), and compare it with values from hypertensive patients, and (2) to evaluate the impact of isolated and untreated hypertension on arterial stiffness. A total of 1079 patients were enrolled and divided into a control group (NT) of asymptomatic normotensive patients and a group of asymptomatic hypertensive patients (HT).Blood pressure, carotid-femoral PWV, and body mass index were measured in each subject, whose blood was drawn for laboratory tests. Aortic mean PWV in the NT group was 6.85 ± 1.66 m/s, which increased linearly (R 2 = 0.62; P < .05) with age. In patients over 50 years of age, PWV was significantly higher than in younger patients However, the impact of isolated hypertension on aortic elasticity in non-treated patients has not been specifically analyzed. | INTRODUCTIONConsequently, the purpose of this research was to evaluate the effects of isolated and untreated hypertension on AS in a representative sample a city from Argentina. Thus, the specific aims of this work were:

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“…Existing studies show controversial results with respect to sex‐related differences in cfPWV. Moreover, the influence of sex on AS remains to be defined . Considering the above‐mentioned discrepancies, the need for sex‐specific cfPWV percentiles and RIs obtained in a large healthy Argentinean cohort is evident.…”

Section: Introductionmentioning

confidence: 99%

“…It was later demonstrated that hypertension, age, and diabetes mellitus were main determinants of cfPWV . cfPWV is currently considered a predictor of cardiovascular risk and a prognostic marker of all‐cause mortality even for populations of different backgrounds and medical conditions . An increase of one standard deviation in cfPWV represents an increase in mortality and risk of cardiovascular events equivalent to 10 years of aging, or more than 1.5 times the risk determined by increases of 10 mm Hg of systolic blood pressure (SBP) values …”

Section: Introductionmentioning

confidence: 99%

Reference intervals and percentiles for carotid‐femoral pulse wave velocity in a healthy population aged between 9 and 87 years

Díaz¹,

Zócalo

Bia

et al. 2018

J of Clinical Hypertension

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There is little information regarding age‐related reference intervals (RIs) of carotid‐femoral pulse wave velocity (cfPWV) for large healthy populations in South America. The aims of this study were to determine cfPWV RIs and percentiles in a cohort of healthy children, adolescents, and adults and to generate year‐to‐year percentile curves and body‐height percentile curves for children and adolescents. cfPWV was measured in 1722 healthy participants with no cardiovascular risk factors (9–87 years, 60% men). First, RIs were evaluated for males and females through correlation and covariate analysis. Then, mean and standard deviation age‐related equations were obtained for cfPWV using parametric regression methods based on fractional polynomials and age‐specific (year‐to‐year) percentile curves that were defined using the standard normal distribution. Age‐specific first, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97.5th, and 99th percentile curves were calculated. Finally, height‐related cfPWV percentile curves for children and adolescents (<21 years) were established. After adjusting for age and blood pressure differences with respect to females, males showed higher cfPWV levels (6.60 vs 6.45 m/s; P < .01). Thus, specific RIs for males and females were reported. The study provides the largest database to date concerning cfPWV in healthy people from Argentina. Specific RIs and percentiles of cfPWV are now available according to age and sex. Specific percentiles of cfPWV according to body height were reported for people younger than 21 years.

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Gender differences in arterial structure and function. Are men really from Mars and women from Venus?

Cited by 3 publications

References 22 publications

Reference Values of Pulse Wave Velocity in Healthy People from an Urban and Rural Argentinean Population

Reference Values of Pulse Wave Velocity in Healthy People from an Urban and Rural Argentinean Population

The effects of age on pulse wave velocity in untreated hypertension

Reference intervals and percentiles for carotid‐femoral pulse wave velocity in a healthy population aged between 9 and 87 years

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