The effects of age on pulse wave velocity in untreated hypertension

Abstract

Increased arterial stiffness is an important determinant of cardiovascular risk, able to predict morbidity and mortality, and closely associated with ageing and blood pressure. The aims of this study were: (1) To determine the age-dependent reference pulse wave velocity (PWV), and compare it with values from hypertensive patients, and (2) to evaluate the impact of isolated and untreated hypertension on arterial stiffness. A total of 1079 patients were enrolled and divided into a control group (NT) of asymptomatic normotensive patients and a group of asymptomatic hypertensive patients (HT).Blood pressure, carotid-femoral PWV, and body mass index were measured in each subject, whose blood was drawn for laboratory tests. Aortic mean PWV in the NT group was 6.85 ± 1.66 m/s, which increased linearly (R 2 = 0.62; P < .05) with age. In patients over 50 years of age, PWV was significantly higher than in younger patients However, the impact of isolated hypertension on aortic elasticity in non-treated patients has not been specifically analyzed. | INTRODUCTIONConsequently, the purpose of this research was to evaluate the effects of isolated and untreated hypertension on AS in a representative sample a city from Argentina. Thus, the specific aims of this work were:

Normal percentile curves for left atrial size in healthy children and adolescents

“…This study is part of a project started in 2010 in Tandil County (located 360 km south of Buenos Aires City), Argentina, aimed at investigating the cardiovascular disease and CRFs in a population‐based study. Preliminary data and reference values for several cardiovascular variables in children and adolescents have recently been published . The study protocol was approved by the Institutional Ethics Committee and pursued in agreement with the Declaration of Helsinki and the Good Clinical Practice Guidelines.…”

“…Preliminary data and reference values for several cardiovascular variables in children and adolescents have recently been published. [18][19][20] The study protocol was approved by the Institutional Ethics Committee and pursued in agreement with the Declaration of Helsinki and the Good Clinical Practice Guidelines. Written informed consent was always obtained from the participants or guardians in case of children or adolescents.…”

Reference intervals and percentiles for carotid‐femoral pulse wave velocity in a healthy population aged between 9 and 87 years

“…This study is part of a project that started in 2010 in Tandil, Buenos Aires Province, Argentina, aimed at investigating the prevalence of CRFs. Preliminary data have been published . Tandil is located 360 km to the south of Buenos Aires city (37°19′08″S9°08′05″W).…”

“…All parameters were measured in patients after 15 minutes of rest in the supine position in a temperature‐controlled (≈22°C) room, in order to reach steady hemodynamic conditions. cfPWV was measured using two high‐fidelity strain gauges mechanotransducers (Motorola MPX 2050, Motorola Inc.) connected to an electronic signal amplifier device (Arteriometer, model V100), as described in other works . The mechanotransducers were positioned on the skin over the carotid and femoral arteries to record, simultaneously, the arterial BP waves.…”

Reference intervals and percentile curve for left ventricular outflow tract (LVOT), velocity time integral (VTI), and LVOT‐VTI‐derived hemodynamic parameters in healthy children and adolescents: Analysis of echocardiographic methods association and agreement

“…This research is part of a project started in 2014 in Tandil, Argentina, aimed at investigating the prevalence of CRFs . RIs for several cardiovascular variables have recently been published .…”