Gender Differences in Alcohol Impairment of Simulated Driving Performance and Driving-Related Skills

Miller, Melissa A.; Weafer, Jessica; Fillmore, Mark T.

doi:10.1093/alcalc/agp051

Cited by 80 publications

(62 citation statements)

References 47 publications

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“…This result replicates previous findings reporting an effect of alcohol on dual task reaction times (Fillmore and Van Selst, 2002;Marczinski and Fillmore, 2006;Marczinski et al, 2012;Miller et al, 2009;Schweizer et al, 2005;Schweizer and Vogel-Sprott, 2008).…”

Section: Alcohol Affects Action-updating and Motor Executionsupporting

confidence: 91%

Impairment of manual but not saccadic response inhibition following acute alcohol intoxication

Campbell

Chambers

Allen

et al. 2017

Drug and Alcohol Dependence

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A B S T R A C TBackground: Alcohol impairs response inhibition; however, it remains contested whether such impairments affect a general inhibition system, or whether affected inhibition systems are embedded in, and specific to, each response modality. Further, alcohol-induced impairments have not been disambiguated between proactive and reactive inhibition mechanisms, and nor have the contributions of action-updating impairments to behavioural 'inhibition' deficits been investigated. Methods: Forty Participants (25 female) completed both a manual and a saccadic stop-signal reaction time (SSRT) task before and after a 0.8 g/kg dose of alcohol and, on a separate day, before and after a placebo. Blocks in which participants were required to ignore the signal to stop or make an additional 'dual' response were included to obtain measures of proactive inhibition as well as updating of attention and action. Results: Alcohol increased manual but not saccadic SSRT. Proactive inhibition was weakly reduced by alcohol, but increases in the reaction times used to baseline this contrast prevent clear conclusions regarding response caution. Finally, alcohol also increased secondary dual response times of the dual task uniformly as a function of the delay between tasks, indicating an effect of alcohol on action-updating or execution. Conclusions: The modality-specific effects of alcohol favour the theory that response inhibition systems are embedded within response modalities, rather than there existing a general inhibition system. Concerning alcohol, saccadic control appears relatively more immune to disruption than manual control, even though alcohol affects saccadic latency and velocity. Within the manual domain, alcohol affects multiple types of action updating, not just inhibition.

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Section: Alcohol Affects Action-updating and Motor Executionsupporting

confidence: 91%

Impairment of manual but not saccadic response inhibition following acute alcohol intoxication

Campbell

Chambers

Allen

et al. 2017

Drug and Alcohol Dependence

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“…Another potential but understudied influence is sex/gender. Although evidence suggests that BrACs of 80 mg/dl or more might differentially affect men and women (Fillmore & Weafer, 2004;Miller et al, 2009), few investigations have considered sex when evaluating lower doses (for a review, see Nixon et al, 2014).…”

mentioning

confidence: 99%

Alcohol Doesn’t Always Compromise Cognitive Function: Exploring Moderate Doses in Young Adults

Hoffman

Nixon

2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: The purpose of this study was to clarify inconsistent findings regarding the acute cognitive effects of subintoxicating alcohol doses (i.e., <80 mg/dl) by controlling for and evaluating variables that might modulate dose-related outcomes. Method: The current study examined the effects of sex/gender and alcohol concentration on select cognitive functions in 94 individuals (49 men) between 25 and 35 years of age. Participants were randomly assigned to one of three dose conditions: target peak breath alcohol concentration of 0 mg/dl (placebo), 40 mg/dl (low), or 65 mg/dl (moderate). After beverage consumption, they completed tasks assessing psychomotor, set-shifting, and working memory ability. Results: Analyses revealed no significant effect of dose for any cognitive domain. A trend-level effect of dose on psychomotor performance was observed, with the low-dose group performing somewhat better than the moderate-dose and placebo groups. No sex main effects or interactions were revealed. Conclusions: Consistent with our previous studies, these data suggest that low and moderate doses of alcohol may not compromise cognitive ability in non-problem drinkers under certain task conditions. Given the outcomes, sex differences cannot be meaningfully addressed. Future consideration of potentially influential variables and assessment of similarly well-defined cohorts might yield a clearer interpretation of alcohol's behavioral consequences. (J. Stud. Alcohol Drugs, 76, 952-956, 2015)

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“…El mayor impacto negativo en hombres se debe a su mayor exposición al alcohol 198 . De hecho, aunque hay ciertas diferencias por sexo en los efectos fisiológi-cos del alcohol [199][200][201][202] , las diferencias en el riesgo relativo para problemas de salud concretos no son grandes e incluso para algunos problemas el riesgo es mayor para mujeres 3,42,192,[203][204][205][206][207][208][209][210][211][212][213][214] . Los efectos protectores para coronariopatía, mortalidad general y otros problemas de salud aparecen a dosis más bajas en mujeres que en hombres y lo mismo sucede con los efectos negativos 95,104,215 .…”

Section: Desigualdades Sociales En Los Daños Relacionados Con El Alcoholunclassified

“…Los efectos protectores para coronariopatía, mortalidad general y otros problemas de salud aparecen a dosis más bajas en mujeres que en hombres y lo mismo sucede con los efectos negativos 95,104,215 . Los efectos de la IEA sobre las conductas violentas o la conducción parecen mayores en mujeres 201,204 . Recientemente se observó que las mujeres con TUA tenían un riesgo relativo de muerte significativamente mayor que los hombres, aunque las diferencias no eran grandes 42 .…”

Section: Desigualdades Sociales En Los Daños Relacionados Con El Alcoholunclassified

Principales daños sanitarios y sociales relacionados con el consumo de alcohol

Sarasa-Renedo¹,

Sordo²,

Molist³

et al. 2014

Rev. Esp. Salud Publica

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Gender Differences in Alcohol Impairment of Simulated Driving Performance and Driving-Related Skills

Cited by 80 publications

References 47 publications

Impairment of manual but not saccadic response inhibition following acute alcohol intoxication

Impairment of manual but not saccadic response inhibition following acute alcohol intoxication

Alcohol Doesn’t Always Compromise Cognitive Function: Exploring Moderate Doses in Young Adults

Principales daños sanitarios y sociales relacionados con el consumo de alcohol

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