Gender and Renal Insufficiency: Opportunities for Their Therapeutic Management?

Ciarambino, Tiziana; Giordano, Mauro

doi:10.3390/cells11233820

Cited by 13 publications

(10 citation statements)

References 101 publications

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“…We hypothesized that CKD is closely associated with metabolic factors in Mianzhu. In addition, as in Ciarambino’s study, the physiological differences in tubular absorption and secretory function between men and women may also account for the higher prevalence of CKD in men ( 38 ).…”

Section: Discussionmentioning

confidence: 75%

“…We used this formula, but the prevalence of CKD among men was still higher than that among women in this study. Chronic kidney disease resulting from hypertension or diabetes is more prevalent in men while autoimmune kidney disease or infectious urinary tract disease prevail in female ( 38 ). And in this study, we found that some metabolic risk factors, such as high blood pressure, dyslipidemia, diabetes, and high BMI were more common among men.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of chronic kidney disease and metabolic related indicators in Mianzhu, Sichuan, China

Chen,

Wang,

Jiang

2024

Front. Public Health

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BackgroundChronic kidney disease (CKD) is a major public health problem worldwide. Periodic surveys are essential for monitoring the prevalence of CKD and its risk factors. We assessed the prevalence of CKD and its risk factors in Mianzhu City in 2020.MethodThe Natural Population Cohort Study surveyed 7,770 individuals aged>20 years in Mianzhu City of Sichuan province in 2020. Our investigation encompassed the measurement of CKD prevalence, the evaluation of various renal function indicators, and comparisons based on age, gender, and hukou status. Additionally, some metabolic indices were also measured to identify the underlying causes of CKD.Results(1) Overall, the prevalence of reduced renal function (eGFR<60 mL/min/1.73m2), albuminuria, and CKD were 1.3, 10.0, and 10.4%, respectively, (2) the overall prevalence of CKD was higher among men than among women (14.5% vs. 8.6%). Similarly, the prevalence of CKD was higher among men than women in most age groups, (3) among urban residents, the prevalence of CKD was higher among middle-aged individuals and lower among young individuals and older adults, and (4) considering eGFR, the albuminuria and CKD for group definition, Blood pressure, triglyceride, high-density lipoprotein, blood sugar, and BMI were all statistically different among between normal groups and abnormal groups s in the albuminuria and CKD.ConclusionThe incidence of CKD greatly varied between Mianzhu City and other regions in China and other countries. The differences in risk factors of CKD should be explored in the future. The gender difference in the prevalence of CKD in this study was markedly different from that in previous studies. More high-quality studies are needed to further explore this controversy. Based on the different prevalence of CKD and metabolism-related indices in rural and urban areas in this study, we speculated that the high incidence of CKD in Mianzhu City might be related to diet, lifestyle, and availability of healthcare services.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic kidney disease and metabolic related indicators in Mianzhu, Sichuan, China

Chen,

Wang,

Jiang

2024

Front. Public Health

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“…On the other hand, male hormones have demonstrated a detrimental effect but the molecular mechanisms involved are not clear. Also, the evidence supporting gender differences in the repair and replication processes of damaged renal cells affecting males needs to be further investigated ( 10 , 11 ).…”

Section: Gender and Chronic Kidney Diseasementioning

confidence: 99%

“…Suboptimal renal function (7.9 vs. 0.9% p < 0.0001) and evaluation not completed 6.4 vs. 1.8% p = 0.01) were found to be statistically different between women and men ( 41 ). The aforementioned over estimation of eGFR in women could have influenced renal function differences ( 11 ).…”

Section: Gender and Living Kidney Donationmentioning

confidence: 99%

Access to treatment in chronic kidney disease, dialysis and transplantation. Is there gender equality?

Sleiman,

Soler Pujol,

Montañez

et al. 2023

Front. Med.

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Sex and gender are often used as synonyms. However, while sex describes only a biological state, gender is a dynamic concept that takes into account psychosocial and cultural aspects of human existence that can change according to place and time. Inequality in medicine has been described in several areas. Among them, gender inequality has been disregarded for many years and is now a matter of concern. Chronic kidney disease (CKD) is a growing epidemic worldwide, affecting approximately 10% of the population. Although both men and women are affected, gender equality, especially in access to different treatments, is a matter of concern. We decided to investigate gender equality in patients with CKD. To this end, we conducted a literature narrative review to determine whether gender inequalities were found in CKD patients in general and in access to different treatment modalities in particular. A non-language restricted search was performed until November 30th 2022 in PubMed, SciELO, Trip Database, Google Scholar, MEDES y MEDLINE. We also investigated the situation in this regard in our country. We found that CKD is more prevalent in women than men, nevertheless this prevalence decreases along the CKD stages to the point that more men reach end stage kidney disease (ESKD) and dialysis. Access to transplant (ATT) is higher in men than in women although posttransplant survival shows no gender differences. Finally, most series have shown that women are more frequently Kidney transplantation (KT) living donors than men. Results in our country are similar to the published literature with the exception of a higher proportion of men as KT living donors. As in other areas, gender inequality in Nephrology has been largely overlooked. In this review we have highlighted gender differences in CKD patients. Gender inequality in Nephrology exists and needs to be looked upon in order to reach a personalized clinical approach.

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“…As regards the integrity of the bone system, both in the perimenopausal period and after menopause, vitamin D and calcium supplementation is necessary to counteract the risk of developing osteoporosis and, consequently, the risk of fractures [ 14 , 15 ]. It is, therefore, of fundamental importance to establish the exact role of vitamin D in the function of the various stages of life of the female organism and its role in the development of pathologies related to hormonal status in this category of people [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Little evidence yet exists on the role of vitamin D in human reproduction, although a role of the latter is easily conceivable above all for the fact that the VDR and 1a-hydroxylase are molecules expressed by both male and female reproductive organs [ 24 ].…”

Section: Change In Vitamin D Requirements In Womenmentioning

confidence: 99%

Vitamin D: Can Gender Medicine Have a Role?

2023

Self Cite

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This narrative review aims to shed light on the role of gender differences, on the biological and molecular functions in the main pathological mechanisms that recognize the role of vitamin D. Vitamin D deficiency is widespread worldwide, but it is still very controversial whether the amount of vitamin D taken daily is actually the only problem related to its biological functions. Currently, the plasma concentration of 25-hydroxyvitamin D represents the only indicator of the circulating blood quota. The concept is that the biological function of vitamin D is not only linked to its circulating levels, but it is hypothesized that its biological functions depend, above all, on its total bioavailability. In particular, vitamin D circulates for the most part linked to albumin and vitamin D binding protein (DBP), which depend on various pathological conditions and physiologically, above all, the function of the latter is regulated by estrogens, glucocorticoids, and inflammatory cytokines. During her life, women undergo various changes in the hormonal and sexual sphere concerning menarche, possible pregnancies, and breastfeeding but also the use of contraceptives and, finally, the transition from the period of fertility to menopause. Each of these phases presents specific needs and, consequently, sometimes also specific criticalities. Studies on young women have shown that vitamin D deficiency is present in 58 to 91% of cases. Obesity, metabolic disorders, and variation in estrogen contraction may affect vitamin D deficiency due to the decreased bioavailability from dietary sources due to deposition in body fat compartments.

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Gender and Renal Insufficiency: Opportunities for Their Therapeutic Management?

Cited by 13 publications

References 101 publications

Prevalence of chronic kidney disease and metabolic related indicators in Mianzhu, Sichuan, China

Prevalence of chronic kidney disease and metabolic related indicators in Mianzhu, Sichuan, China

Access to treatment in chronic kidney disease, dialysis and transplantation. Is there gender equality?

Vitamin D: Can Gender Medicine Have a Role?

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