Gemcitabine-induced chronic systemic capillary leak syndrome

Bajwa, Ravneet; Starr, Jason S.; Daily, Karen

doi:10.1136/bcr-2017-221068

Cited by 15 publications

(12 citation statements)

References 14 publications

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“…[3][4][5] Oncologic medications have also been identified as provoking factors of CLS. Drugs including denileukin diftitox, 6,7 gemcitabine, 8 imatinib, 9 and oxaliplatin 10 have been implicated.…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy‐induced skin toxicity and capillary leak syndrome

et al. 2019

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Background The occurrence of chemotherapy‐related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS. Methods Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS. Results Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical‐pathologic confirmation. Conclusions Although TEC is generally self‐limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Chemotherapy‐induced skin toxicity and capillary leak syndrome

et al. 2019

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“…There are only a few case reports on the chronic form of SCLS [4,[10][11][12][13][14][15]. Unlike the classical form, patients with chronic SCLS experience mild progressive generalized edema, along with pleural and pericardial effusions without signs of spontaneous recovery.…”

Section: Discussionmentioning

confidence: 99%

Chronic systemic capillary leak syndrome associated with an intravascular large B-cell lymphoma in a patient undergoing hemodialysis: a case report with literature review

et al. 2021

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Background Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by hypotension, hemoconcentration, and hypoalbuminemia associated with increased capillary endothelium permeability. Patients with a chronic form of SCLS present with persistent and progressive generalized edema. However, there have been no reports of chronic SCLS in patients undergoing hemodialysis. Herein, we report a case of chronic SCLS associated with an intravascular large B-cell lymphoma (IVLBCL) in a patient undergoing hemodialysis. Case presentation A 71-year-old male had been on hemodialysis for five years due to diabetic nephropathy. Difficulty in body fluid removal was observed during hemodialysis, and the patient was admitted to our hospital due to exacerbated weight gain and lower limb edema. He had elevated serum lactate dehydrogenase (LDH) levels and thrombocytopenia. His blood pressure was low, and his serum brain natriuretic peptide level was relatively low, despite the increase in body fluid volume. His clinical characteristics suggested a chronic form of SCLS. Random skin biopsy revealed IVLBCL; however, the association between IVLBCL and chronic SCLS remained unclear. He underwent chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone, followed by rituximab. After the treatment, his serum LDH level decreased, and the difficulty in body fluid removal during hemodialysis improved. The patient’s chronic SCLS seemed to be complicated by IVLBCL. Conclusions Patients with chronic SCLS who are undergoing hemodialysis seem to present with difficulties in fluid removal. The frequency of SCLS complications in cases with malignant lymphomas, including IVLBCL, is considered to be extremely low. However, clinicians should be aware of SCLS as a complication of malignant lymphomas.

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“…The symptomatology promoted results in an unapparent condition or spectrum of clinical diseases ranging from selflimiting dengue fever to its severe form, a potentially lethal haemorrhagic and capillary leak syndrome, formerly dengue haemorrhagic fever and dengue shock syndrome (Bajwa, et al, 2017). Primary infection with a DENV confers long-term immunity only to this serotype, but not to the other three (Tang, et al, 2020).…”

Section: General Aspects Of Dengue Zika Fever and Chikungunyamentioning

confidence: 99%

Dengue, Zika Fever e Chikungunya: Aspectos Biológicos e Situação na América do Sul entre 2015 e 2020

Silva

Araújo

Barbosa

2021

RSD

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Arboviroses são doenças causadas por vírus transmitidos por artrópodes e afetam as Américas, incluindo a América do Sul, onde provocam impactos na economia e na saúde pública. Entre os mais de 500 vírus registrados no Catálogo Internacional de Arbovírus, destacam-se os que causam dengue, febre zika e chikungunya. Assim, este artigo compreende um estudo descritivo baseado em dados secundários, onde são comparados aspectos biológicos e diagnósticos em relação a essas três enfermidades, bem como avaliamos sua presença, entre 2015 e 2020, nos países que integram a porção continental sul-americana. Apesar do considerável progresso feito nos últimos anos para melhor compreender os aspectos moleculares dos agentes etiológicos e das condições clínicas, o cenário é complexo e os três arbovírus causaram surtos na América do Sul, no período descrito, em proporções diferentes, e a dengue a mais comum, cujas taxas de incidência variam a cada ano analisado. O combate aos arbovírus deve ser permanente e requer políticas intersetoriais bem fundamentadas e responsabilidade individual. As intervenções governamentais precisam estreitar-se para implementar medidas de combate, e os sistemas de saúde e educação poderiam se alinhar de forma mais eficaz a fim de um trabalho mais forte de sensibilização que seja desencadeado desde os alunos da educação básica, auxiliando na educação continuada da população a favor da uma sociedade mais orientada e prudente. Também é necessário refletir sobre a eficácia dos sistemas de informações a fim de minimizar o problema da subnotificação, que impede de mostrar o real cenário dessas doenças.

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Gemcitabine-induced chronic systemic capillary leak syndrome

Cited by 15 publications

References 14 publications

Chemotherapy‐induced skin toxicity and capillary leak syndrome

Chemotherapy‐induced skin toxicity and capillary leak syndrome

Chronic systemic capillary leak syndrome associated with an intravascular large B-cell lymphoma in a patient undergoing hemodialysis: a case report with literature review

Dengue, Zika Fever e Chikungunya: Aspectos Biológicos e Situação na América do Sul entre 2015 e 2020

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