Gellan Gum in Wound Dressing Scaffolds

Abstract

Several factors, such as bacterial infections, underlying conditions, malnutrition, obesity, ageing, and smoking are the most common issues that cause a delayed process of wound healing. Developing wound dressings that promote an accelerated wound healing process and skin regeneration is crucial. The properties of wound dressings that make them suitable for the acceleration of the wound healing process include good antibacterial efficacy, excellent biocompatibility, and non-toxicity, the ability to provide a moist environment, stimulating cell migration and adhesion, and providing gaseous permeation. Biopolymers have demonstrated features appropriate for the development of effective wound dressing scaffolds. Gellan gum is one of the biopolymers that has attracted great attention in biomedical applications. The wound dressing materials fabricated from gellan gum possess outstanding properties when compared to traditional dressings, such as good biocompatibility, biodegradability, non-toxicity, renewability, and stable nature. This biopolymer has been broadly employed for the development of wound dressing scaffolds in different forms. This review discusses the physicochemical and biological properties of gellan gum-based scaffolds in the management of wounds.

Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

“…Compared with other methods for microsphere fabrication such as single emulsion, phase separation, spray drying, and membrane emulsification, microfluidic technology has many advantages, such as the ability to control microsphere shape and size, high drug loading capacity, and control over the physical and chemical properties of microspheres by manipulating solvent type and polymer concentration. , Hydrogel microspheres hold great promise for tissue repair applications, such as cellular and drug therapy delivery. , In this study, GG was selected to prepare the hydrogel microspheres. GG is a thermosensitive hydrogel scaffold that is a transparent solution at elevated temperatures and a transparent solid at low temperatures. , GG possesses unique physical and chemical properties, such as the ability to form a gel through both thermal and ion-cross-linking mechanisms. , In this study, Ca 2+ was used to induce GG gelation. The gelation mechanism mainly includes the formation of a double-helix region, followed by the formation of a three-dimensional network through the association of cations and hydrogen bonding with water .…”

“…43,12 GG possesses unique physical and chemical properties, such as the ability to form a gel through both thermal and ion-cross-linking mechanisms. 44,45 In this study, Ca 2+ was used to induce GG gelation. The gelation mechanism mainly includes the formation of a double-helix region, followed by the formation of a three-dimensional network through the association of cations and hydrogen bonding with water.…”

Gellan Gum as a Unique Microbial Polysaccharide: Its Characteristics, Synthesis, and Current Application Trends

“…There have been several cutting-edge advancements in the use of GG to develop responsive systems in the field of biomedical applications ( Table 9 ). The latest developments in the use of GG in various biomedical fields demonstrate its ability to advance drug delivery [ 107 , 110 , 111 , 112 ], tissue engineering [ 113 , 114 ], wound healing [ 115 , 116 ], and diagnostics [ 111 , 117 ]. The responsive nature of GG enables the development of specific systems that react to particular physiological signals, enhancing their efficiency and flexibility in different biomedical scenarios.…”

Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review

“…Drug delivery systems can be classified into passive, active, and smart systems [70], the addition of phytochemicals from natural products such as honey or propolis promotes an optimal microenvironment for wound healing. Passive approaches utilize a continuous release of drugs from the wound dressing [71]. On the other hand, active systems employ an external stimulus (e.g., temperature, electrical signal, light, etc.)…”