Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review

Jaldin-Crespo, Limberg; Silva, Nataly; Martínez, Jessica

doi:10.3390/nano12244409

Cited by 8 publications

(6 citation statements)

References 106 publications

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“…Recently, a systematic review and meta-analysis of more than 40 published studies found strong evidence that propolis is effective in the treatment of skin wounds, including difficult-to-heal ulcers found in patients with diabetes; in fact, propolis was shown to promote a higher percentage of healing than the interventions classically employed [25]. Another interesting aspect is that a large number of in vivo studies have combined propolis with other substances, such as honey, and different biomaterials (nanoparticles, nanofibrous, biocelullose membrane, hydrogel) to achieve additive or synergistic effects in the skin regeneration process [25,[57][58][59][60][61][62].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis

Balderas-Cordero¹,

Canales-Alvarez

Sánchez-Sánchez

et al. 2023

IJMS

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Skin wound healing is a complex biochemical process of tissue repair and remodeling in response to injury. Currently, the drugs used to improve the healing process are inaccessible to the population, are costly, and have side effects, making the search for new treatment alternatives necessary. Propolis is a natural product produced by bees that is widely recognized and used in folk medicine for its multiple biomedical activities. However, therapeutic information regarding Mexican propolis is limited. This study aimed to evaluate the wound-healing effect of the Chihuahua ethanolic extract of propolis (ChEEP). Macroscopic and histological analyses were performed using a mouse wound-healing model. The topic acute toxicity assay showed that propolis at 10% w/v had no toxic effects. ChEEP has antibacterial activity against the Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis. Moreover, it exhibited good anti-inflammatory activity evaluated through mouse ear edema induced by 12-O-tetradeca-noylphorbol-13-acetate (TPA). A full-thickness incision lesion was created in mice and treated topically with 10% ChEEP. At Day 14 post-treatment, it was observed that propolis increased wound contraction and reduced healing time and wound length; furthermore, propolis increased the tensile strength of the wound, as determined with the tensiometric method, and promoted the formation of type I collagen at the site of injury, as evaluated with Herovici stain. These findings suggest that the topical administration of ChEEP can improve skin wound healing, probably due to the synergistic effect of its components, mainly polyphenols, in different steps of the wound-healing process. It should be noted this is the first time that the wound-healing activity of a Mexican propolis has been evaluated.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis

Balderas-Cordero¹,

Canales-Alvarez

Sánchez-Sánchez

et al. 2023

IJMS

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“…Biofilm refers to microorganism communities in wounds, which can hinder the healing process due to increased bacterial resistance. However, honey comes to the rescue by also being effective against biofilm bacteria [ 215 ]. When curcumin was released from electrospun nanofibers made of chitosan and polylactic acid, it showed no harmful effects on L-929 fibroblast cells and increased antioxidant activity in vitro.…”

Section: In-vitro Studiesmentioning

confidence: 99%

Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing

Palani,

Vijayakumar,

Monisha

et al. 2024

J Nanobiotechnol

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The development of innovative wound dressing materials is crucial for effective wound care. It’s an active area of research driven by a better understanding of chronic wound pathogenesis. Addressing wound care properly is a clinical challenge, but there is a growing demand for advancements in this field. The synergy of medicinal plants and nanotechnology offers a promising approach to expedite the healing process for both acute and chronic wounds by facilitating the appropriate progression through various healing phases. Metal nanoparticles play an increasingly pivotal role in promoting efficient wound healing and preventing secondary bacterial infections. Their small size and high surface area facilitate enhanced biological interaction and penetration at the wound site. Specifically designed for topical drug delivery, these nanoparticles enable the sustained release of therapeutic molecules, such as growth factors and antibiotics. This targeted approach ensures optimal cell-to-cell interactions, proliferation, and vascularization, fostering effective and controlled wound healing. Nanoscale scaffolds have significant attention due to their attractive properties, including delivery capacity, high porosity and high surface area. They mimic the Extracellular matrix (ECM) and hence biocompatible. In response to the alarming rise of antibiotic-resistant, biohybrid nanofibrous wound dressings are gradually replacing conventional antibiotic delivery systems. This emerging class of wound dressings comprises biopolymeric nanofibers with inherent antibacterial properties, nature-derived compounds, and biofunctional agents. Nanotechnology, diminutive nanomaterials, nanoscaffolds, nanofibers, and biomaterials are harnessed for targeted drug delivery aimed at wound healing. This review article discusses the effects of nanofibrous scaffolds loaded with nanoparticles on wound healing, including biological (in vivo and in vitro) and mechanical outcomes. Graphical Abstract

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“…From fibers electrospun with honey to the healing of wounds: A review of abnormal collagen and the synthesis of normal collagen with its maturation (28) and promotes the emergence of blood vessels (29)(30)(31)(32).…”

Section: Honey As a Therapeutic Agent In Wound Healingmentioning

confidence: 99%

From fibers electrospun with honey to the healing of wounds: a review

Rubiano-Navarrete,

Rosas Cuesta,

Torres Perez

et al. 2024

inycomp

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In order to take advantage of the antiseptic and healing properties of honey, the preparation of polymeric micro and nanofibers with honey from bees has been investigated in many parts of the world, in order to enhance their use in the development of biomedical products such as dressings, bandages and other elements that favor wound closure and tissue restoration. To contribute to this line of research, a background review is presented here on the application of the electrospinning technique in the preparation of micro and nanofiber membranes with honey, focusing on experimental methodology including the use of polymers, solvents, therapeutic agents, active principles or drugs loaded in apitherapeutic fibers. Electrospinning techniques and parameters, tests and material characterization methods have been compiled, presenting the effect of these variables on the compositional, morphological, mechanical and physicochemical properties of the fibrous meshes. A compendium of biological tests evaluated in vitro and in vivo was made in order to analyze the functionality and potential of the application of fibers in tissue engineering, as well as in the construction of devices for clinical diagnosis and in general for the development of advanced materials for wound treatment. This review sees the establishment of the methodological foundations for the design of new materials based on honey and plant extracts not yet explored, and which could be developed into compounds of high scientific and industrial interest.

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Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review

Cited by 8 publications

References 106 publications

Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis

Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis

Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing

From fibers electrospun with honey to the healing of wounds: a review

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