Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model

Wan, Xing; Pan, Tao; Nie, Hongping

doi:10.1111/j.1442-9071.2011.02558.x

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Jiang Han Plain, with high precipitation, humid climate, rich vegetation, and dense distribution of water resource, which was a favourable environment for fungal growth. Corneal plant injury was more common due to the predominantly agricultural population, but the economic conditions were relatively low, resulting in relatively backward timeliness and accuracy of diagnosis and treatment [7].…”

Section: Discussionmentioning

confidence: 99%

Clinical Analysis of 137 Cases of Fungal Keratitis

Tian,

Zhang,

Zhu

et al. 2023

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Objective: To analyze the epidemiology, clinical diagnosis and treatment of fungal keratitis (FK) in hospitalized patients at the First Affiliated Hospital of Yangtze University in recent years. Methods: A retrospective investigation was conducted on the data of 137 cases of FK in our hospital from January 2019 to December 2022. The epidemiological characteristics, identification results of fungal strains, clinical treatment, and prognosis of the patients were analyzed. Results: Among the 137 FK patients, 89 were males and 48 were females, and the ratio of male to female was 1.85:1, The age of onset was the largest number of patients in 50 -59 years old and 60 -69 years old. The disease occurred most in autumn, winter and summer farming season (from September to December, January, May, June). 72 cases (52.6%) had a clear history of corneal injury, and 43 cases (31.4%) had a history of plant injury. Other risk factors include eye surface diseases, ophthalmic surgery, and wearing corneal contact lenses. The top three pathogens were fusarium (38.7%), aspergillus (23.3%), and alternaria (17.5%). 101 eyes showed improvement or cure after treatment with medication, 9 eyes underwent corneal stromal injection, 11 eyes were covered with conjunctival flap covering or amniotic membrane transplantation, 12 eyes were covered with corneal transplantation, and enucleation of ocular contents was performed in 4 eyes; Visual acuity was improved or maintained in 123 patients (about 89.8%). Conclusions: The incidence of FK in our hospital was mostly middle-aged and elderly men, mostly caused by corneal injury in the process of agricultural labor. The pathogens were mainly fusarium and aspergillus. The preferred treatment was medication, with severe cases requiring combined surgical treatment. Most patients can maintain or improve their vision after treatment.

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Section: Discussionmentioning

confidence: 99%

Clinical Analysis of 137 Cases of Fungal Keratitis

Tian,

Zhang,

Zhu

et al. 2023

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“…In vivo validation of the pro-viral roles of TTC4 and HSP90 would be challenging to perform as small animal BoHV-1 model are limited to rabbits or immunocompromised mice [31,32] and large animal models are taxing for practical, financial, and ethical reasons. However, bovine lung and reproductive tract explants and in vitro neuronal models have previously been used to study BoHV-1 [24,28,33,34], and this would be valuable future work. Another barrier to the therapeutic use of HSP90 inhibitors is the development of a product accessible to the veterinary market.…”

Section: Discussionmentioning

confidence: 99%