Multiple isoforms of HSP70 and HSP90 required for betanodavirus multiplication in medaka cells

Zenke, Kosuke; Okinaka, Yasushi

doi:10.1007/s00705-022-05489-5

Cited by 7 publications

(2 citation statements)

References 84 publications

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“…The induction of hsp70 was only observed in DlNNV-inoculated sea bream, and further studies are required in order to clarify the role of this gene in the course of RGNNV infection in sea bream, since HSP70 has been reported to have both, antiviral and pro-viral effects. Thus, this protein has been demonstrated to be a host factor promoting RGNNV replication in grouper ( Epinephelus coioides ) and medaka ( Oryzias latipes ) cells [ 59 , 60 ], in addition to being involved in both, adaptative and innate immune responses [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Immune Gene Transcription in Sea Bream (Sparus aurata) Challenged with RGNNV or RGNNV/SJNNV Betanodaviruses

Gemez-Mata,

Moreno,

Alvarez-Torres

et al. 2024

Pathogens

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Gilthead sea bream and European sea bass display different resistance–susceptibility patterns during infection with different nervous necrosis virus (NNV) species, which may derive from differences in the triggered immune response. Based on this premise, we analysed the transcription of several selected immune-related genes in sea bream experimentally infected with NNV isolates obtained from sea bass (DlNNV, RGNNV) or sea bream (SaNNV, RGNNV/SJNNV). Viral replication only occurred in SaNNV-inoculated fish; therefore, the differences between the immune response elicited by both viruses may be the key to understanding the mechanism behind the inhibition of DlNNV replication. Principal component analysis clustered samples according to the viral isolate from 1 day post infection onwards and evidenced differences in the immune response against both viruses, even though no mortalities or symptoms were recorded. The response against DlNNV is characterized by higher rtp3 transcription early after the infection, longer-lasting il-10 transcription and stronger induction of casp1 and hsp70. These genes should be targets for future studies in order to elucidate their role in hampering NNV replication in sea bream, which is essential for developing effective prophylactic measures.

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Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Immune Gene Transcription in Sea Bream (Sparus aurata) Challenged with RGNNV or RGNNV/SJNNV Betanodaviruses

Gemez-Mata,

Moreno,

Alvarez-Torres

et al. 2024

Pathogens

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“…Our results show that HSP90 expression in the muscles of T. fasciatus is signi cantly expressed at low temperatures, which is consistent with the ndings of previous studies. HSP70 is a kind of under the stress cell rapid synthesis of protein, highly conservative, stress can produce protection, tolerance, and have cross tolerance, can remove stress caused by abnormal or denatured protein, has the effect of activating other cell genes, can inhibit cell apoptosis caused by ATP loss [37,38,39]. Liu et al [40] found that low temperature stress increased HSP70 levels in Puntius tetrazona, suggesting that the expression of the molecular chaperone HSP70 in Puntius tetrazona may play a key role in the response to acute cold stress.…”

Section: High-resolution Genetic Mapmentioning

confidence: 99%

Construction of a high-density genetic linkage map and QTL mapping of growth and cold tolerance traits in Takifugu fasciatus

Zhang

Liu

Chu

et al. 2023

Preprint

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Takifugu fasciatus is an aquaculture species with high economic value. In recent years, problems such as environmental pollution and inbreeding have caused a serious decline of T. fasciatus germplasm resources. This study, a high-density genetic linkage map was constructed by whole-genome resequencing. The map consists of 4891 bin markers distributed across 22 linkage groups (LG), with a total genetic coverage of 2381.353 cM and a mean density of 0.535 cM. QTL (quantitative trait locus) localization analysis showed that a total of 19 QTL associated with growth traits of T. fasciatus were identified in the genome-wide significance threshold range, distributed on 11 LGs. In addition, 11 QTLs associated with cold tolerance traits were identified, each scattered on a different LG. Further, we used QTL localization analysis to screen out three candidate genes (IGF1, IGF2, ADGRB) related to growth in T. fasciatus. Meanwhile, we screened three candidate genes (HSP90, HMGB1, HMGB1) related to cold tolerance of T. fasciatus. Our study can provide a theoretical basis for the selection and breeding of cold-tolerant or fast-growth T. fasciatus.

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Effect of Bacillus licheniformis probiotic on the culture of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus polyphekadion)

Huang,

Amenyogbe,

Wen

et al. 2023

Aquaculture Reports

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Multiple isoforms of HSP70 and HSP90 required for betanodavirus multiplication in medaka cells

Cited by 7 publications

References 84 publications

Comparative Analysis of Immune Gene Transcription in Sea Bream (Sparus aurata) Challenged with RGNNV or RGNNV/SJNNV Betanodaviruses

Comparative Analysis of Immune Gene Transcription in Sea Bream (Sparus aurata) Challenged with RGNNV or RGNNV/SJNNV Betanodaviruses

Construction of a high-density genetic linkage map and QTL mapping of growth and cold tolerance traits in Takifugu fasciatus

Effect of Bacillus licheniformis probiotic on the culture of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus polyphekadion)

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