Gelatin/PVA scaffolds fabricated using a 3D-printing process employed with a low-temperature plate for hard tissue regeneration: Fabrication and characterizations

Kim, Haeri; Yang, Gi Hoon; Park, Chul Hyun; Cho, Yong Suk; Kim, GeunHyung

doi:10.1016/j.ijbiomac.2018.07.159

Cited by 83 publications

(37 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The transformation from conventional material extrusion-based 3D printer to a LTDM machine is a technology barrier. In addition, commercially available printable inks for LTDM Figure 9: LTDM process by extruding materials onto a low-temperature building plate [83]. Reproduced with permission.…”

Section: Discussionmentioning

confidence: 99%

“…Another possible strategy to combine 3D printing and TIPS is to extrude materials onto a low-temperature building plate to freeze the extruded solution and maintain the geometry of printed objects (as shown in Figure 9). Using this strategy, porous gelatin/poly(vinyl alcohol) (PVA) composite scaffolds and collagen/decellularized extracellular matrix (dECM)/silkfibroin composite scaffolds have been fabricated [83,84]. The temperature of the building plate can be adjusted within a certain range from -5°C to -40°C.…”

Section: Other Forms Of Ltdmmentioning

confidence: 99%

See 1 more Smart Citation

Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

Liu

Tong

et al. 2019

Journal of Nanomaterials

View full text Add to dashboard Cite

Low-temperature deposition manufacturing (LTDM) is a technology that combines material extrusion-based 3D printing and thermally induced phase separation (TIPS) into one process. With this feature, both the merits of 3D printing and TIPS can be incorporated including complex geometries with tailorable ordered macroporous features facilitated by 3D printing and microporous/nanoporous features endowed by TIPS. These macroporous/microporous/nanoporous combined structures are important to some important applications such as tissue engineering scaffolds, porous electrodes for electrochemical energy storage, purification, and filtering applications. However, the unique advantages and potential applications of LTDM have not been fully recognized and exploited yet. In this review, we will discuss the origin, principle, advantages, processes, and machine setup of LTDM technology with an emphasis on its unique advantages in fabricating porous materials. Then, current applications of LTDM including porous tissue engineering scaffolds and emerging porous electrodes for electrochemical storage will be described. The versatility of LTDM including its capability of processing a wide range of materials, multimaterial and gradient structures, and core-shell structures will be introduced. Finally, we will conclude with a perspective and outlook on the future development and applications of LTDM technology.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Other Forms Of Ltdmmentioning

confidence: 99%

Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

Liu

Tong

et al. 2019

Journal of Nanomaterials

View full text Add to dashboard Cite

show abstract

“…PVA and gelatin-based hydrogel mimicked the suitable morphology and biological properties for tissue formation, which can be used as a cartilage scaffold for osteoarthritis surgery [116]. Some PVA-based scaffolds are successfully used in different tissue engineering applications, which include cardiovascular tissue engineering [117], bone tissue engineering [118], hard tissue regeneration [119], cartilage repair [120], and skin tissue regeneration [121].…”

Section: Synthetic Polymer-based Biomaterialsmentioning

confidence: 99%

Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

Kumar

Abrahamse

2020

IJMS

View full text Add to dashboard Cite

Recent advancement in nanotechnology has provided a wide range of benefits in the biological sciences, especially in the field of tissue engineering and wound healing. Nanotechnology provides an easy process for designing nanocarrier-based biomaterials for the purpose and specific needs of tissue engineering applications. Naturally available medicinal compounds have unique clinical benefits, which can be incorporated into nanobiomaterials and enhance their applications in tissue engineering. The choice of using natural compounds in tissue engineering improves treatment modalities and can deal with side effects associated with synthetic drugs. In this review article, we focus on advances in the use of nanobiomaterials to deliver naturally available medicinal compounds for tissue engineering application, including the types of biomaterials, the potential role of nanocarriers, and the various effects of naturally available medicinal compounds incorporated scaffolds in tissue engineering.

show abstract

“…Several publications suggest the use of PVA or PVA-methacrylate (PVA-MA) as the main component for 3D printed soft scaffolds. Yet, in most works describing PVA-based scaffolds, there is at least one additional component, such as gelatin, added to enhance cell attachment (Castilho et al, 2018;Kim et al, 2018;Mahnama et al, 2017;Miao et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol)‐methacrylate with CRGD peptide: A photocurable biocompatible hydrogel

Goldvaser

Epstein

Rosen

et al. 2021

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Polyvinyl alcohol (PVA)-based hydrogels are promising biomaterials for tissue engineering printing applications. However, one of their main disadvantages is their inability to support cell attachment, which is a critical feature for the preparation of biological scaffolds. The goal of this study was to develop a printable, cellsupportive PVA-based bioink with tunable mechanical properties, without using animal-derived polymers which potentially harbor human pathogens. An ultraviolet light (UV) curable PVA-methacrylate (PVA-MA) polymer mixed with Cys-Arg-Gly-Asp (CRGD) peptide was developed. This peptide holds the integrin receptor binding sequence -RGD, that can enhance cell attachment. The additional cysteine was designed to enable its thiol binding under UV to methacrylate groups of the UV curable PVA-MA. Vero cell, as an adherent cell model was used to assess the hydrogel's cell adhesion. It was found that the PVA-MA-CRGD formula enables the preparation of hydrogels with excellent cell attachment and had even shown superior cell attachment properties relative to added gelatin. Adding hyaluronic acid (HA) as a rheologic modulator enabled the printing of this new formula. Our overall data demonstrates the applicability of this mixture as a bioink for soft tissue engineering such as skin, adipose, liver or kidney tissue.

show abstract

Gelatin/PVA scaffolds fabricated using a 3D-printing process employed with a low-temperature plate for hard tissue regeneration: Fabrication and characterizations

Cited by 83 publications

References 42 publications

Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

Poly(vinyl alcohol)‐methacrylate with CRGD peptide: A photocurable biocompatible hydrogel

Contact Info

Product

Resources

About