Gel-phase peptide synthesis on a new high-capacity tetraethyleneglycol diacrylate-crosslinked polystyrene support: Synthesis of pardaxin 16–33.

Renil, Manat; Nagaraj, Ramakrishnan; Pillai, V. N. Rajasekharan

doi:10.1016/s0040-4020(01)89696-4

Cited by 54 publications

(40 citation statements)

References 18 publications

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“…In addition to PS-DVB resin a number of polymers are used in the development of polymer 14,15 , Janda gel 16 , Tenta gel 17 and polyacrylamides 18 . Various organic polymer supports used were extensively reviewed 19,20 .…”

Section: The Selection Of Polymer Supportmentioning

confidence: 99%

Synthesis and Applications of Nano Metallic Particles Anchored on a Novel Polymeric Resin

Varkey¹

2017

Orient. J. Chem

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Nanocatalysis is a rapidly growing research field which involves the use of nanomaterials as catalysts for both homogenous and heterogeneous catalysis. Because of the huge surface area contrasted to bulk matter nanomaterials can function as more efficient catalysts. The main challenge in applying nanoparticles in catalysis is to stabilize and control their size. This problem can be solved by incorporating metal nanoparticles in channels of solid supports. Resin supported metal nanoparticles are popular in many catalytic reactions. Crosslinked polymers are superior because of their ease of filtration and purification. But most of the resins currently using are of having poor reactivity due to their low strength. The support is not acting as a passive solid carrier and the crosslinked polymer is notably influencing the rate of the reactions carried on it. In this review polystyrene crosslinked with 1, 6 -hexanediol diacrylate (HDODA) is introduced for nanoparticle supported catalysis. The amount of crosslinking should be accurately adjusted because this has an intense effect on the reactivity of the synthesized polymer. The flexible nature and suitable swelling features of the styrene-HDODA resin will facilitate successful synthesis and the swelling property of this resin is much more compared to the resins commonly used now. The preparation, characterization and catalytic applications of functional polymers are presented.

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Section: The Selection Of Polymer Supportmentioning

confidence: 99%

Synthesis and Applications of Nano Metallic Particles Anchored on a Novel Polymeric Resin

Varkey¹

2017

Orient. J. Chem

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“…3. hER-NLS peptide Sepharose: The hER NLS sequence published by Chambon's group [Ylikomi et al, 1992] was used in the synthesis of hER NLS peptide. The hER amino acids 256 -303 (RKRDRGGRMLKHKRQR-DDGEGRGEVGSAGDMR AANL WPSPL-MIKRSKK) was synthesized on hydroxymethyl tetraethyleneglycol diacrylate crosslinked polystyrene support using standard Fmoc solid-phase peptide synthesis protocol [Renil et al, 1994].The coupling reactions were carried out using dicyclohexyl carbodiimide coupling procedure and threefold excess of Fmoc protected amino acid derivatives. The stepwise deprotection was carried out using 20% piperidine in N,NЈ dimethyl formamide.…”

Section: Preparation Of Affinity Matricesmentioning

confidence: 99%

Protein-protein interactions that precede the nuclear entry of goat uterine estrogen receptor under cell-free conditions

2000

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Mechanisms associated with a regulated nuclear entry of the goat uterine estrogen receptor (gER), under the influence of estradiol, have been examined using a cell-free system. The gER transport into the nucleus is mediated by a 55-kDa cytosolic protein, p55. Experimental evidence has been provided to demonstrate that p55 binds to the nuclear localization signals (NLS) on the gER. Under hormone-free conditions, a 28-kDa protein, p28, binds to the NLS and prevents the p55 interaction with the NLS. This inhibition is reversed by a 73-kDa protein, p73. It appears that p73 associates with the hormone binding domain (HBD) of the gER under hormone-free conditions. Estradiol binding to the HBD facilitates p73 interaction with p28. This leads to the dissociation of p28 from the NLS, which, in turn, facilitates the binding of p55 to the NLS on the gER. Both p28 and p55 cross-react with monoclonal antibodies against hsp-25 and hsp-70, indicating a possibility that p28 and p55 belong to a superfamily of molecular chaperones. J. Cell. Biochem. 78:650-665, 2000.

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“…[5][6][7][8][9] Another approach to this problem is to use PEG chains as crosslinking units within the resins. [10][11][12][13] Apart from modifications of PS-DVB, copolymerization of hydrophilic monomers has also been performed to prepare alternative materials for solid phase synthesis. [14][15][16][17][18][19][20][21][22] In a solid-phase reaction, the swollen polymer is the equivalent of the solvent in the corresponding solution-phase reaction.…”

Section: Introductionmentioning

confidence: 99%

Functional Beads of Polyvinylpyrrolidone: Promising Support Materials for Solid‐Phase Synthesis

Engström¹,

Helgee²

2006

Macro Chemistry & Physics

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Summary: The solubility properties of polyvinylpyrrolidone (PVP) make it an attractive material for several different polymer‐assisted synthesis applications. However, PVP lacks reactive groups necessary for attaching compounds to the polymer. Furthermore, the radical reactivity of 1‐vinylpyrrolidin‐2‐one (NVP) is different from most other monomers, which results in compositional drift during copolymerization. Therefore, introducing reactive groups into the polymer using this method is intricate. Smaller differences in radical reactivity are expected from monomers that are derivatives of NVP itself. Hence, such monomers provide a way of preparing PVP with adjustable properties. Four new monomers containing pendant double bonds, all derivatives of NVP, were synthesized and used in the preparation of a new type of hydrophilic polymer bead by aqueous suspension polymerization. We also found that undec‐10‐en‐1‐ol can be used as a comonomer for the introduction of functional groups. The lightly crosslinked beads contain hydroxyl groups at a functional loading of 0.28 mmol/g and swell extensively in a broad range of solvents. Their potential as support materials has previously been demonstrated in a five‐step solid‐phase synthesis of 5‐(2,4,6‐trimethoxy‐phenyl)‐cyclohexa‐1,3‐dienecarboxylic acid.Scanning electron microscopy image of dry beads from PVP‐[B]2.magnified imageScanning electron microscopy image of dry beads from PVP‐[B]2.

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Gel-phase peptide synthesis on a new high-capacity tetraethyleneglycol diacrylate-crosslinked polystyrene support: Synthesis of pardaxin 16–33.

Cited by 54 publications

References 18 publications

Synthesis and Applications of Nano Metallic Particles Anchored on a Novel Polymeric Resin

Synthesis and Applications of Nano Metallic Particles Anchored on a Novel Polymeric Resin

Protein-protein interactions that precede the nuclear entry of goat uterine estrogen receptor under cell-free conditions

Functional Beads of Polyvinylpyrrolidone: Promising Support Materials for Solid‐Phase Synthesis

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