GE11 peptide modified CSO-SPION micelles for MRI diagnosis of targeted hepatic carcinoma

Targeted Molecular Imaging Probes Based on Magnetic Resonance Imaging for Hepatocellular Carcinoma Diagnosis and Treatment

“…Specific peptides bind to the EGFR extracellular domain, which is overexpressed on HCC cell surface, thus promoting endocytosis and achieving tumor imaging. Additionally, similar results were obtained in another study targeting EGFR by peptide [93].…”

“…Presently, the aberrant expression of the EGFR and activation of EGFR-mediated downstream signaling pathways have been seen in a large number of human malignant tumors, including HCC. Recently, anti-EGFR targeted imaging and therapy have received a great deal of interest from the medical community [92,93,174]. For example, Chen et al achieved targeted MR imaging by modifying a peptide with a high affinity to EGFR on USPIO [92].…”

Fe3O4 SPIONs in cancer theranostics—structure versus interactions with proteins and methods of their investigation

“…There are numerous examples of targeting moieties that can be used for this purpose: antibodies [70], aptamers [71], hyaluronic acid [72], folate [73], human serum proteins (albumin [74] and transferrin [75]) or various targeting peptides (e.g. H 7 K(R 2 ) 2 [76], ferritin [77], GE11 [78], RGD peptides [79]).…”

Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy

“…The properties of polymer-based nanoparticles-including release profiles, targeting, stability, responsiveness, and ability to encapsulate a wide range of agents [76]-can be precisely controlled by modulating polymer chemistry and particle composition [77]. Due to this tunability, polymer-based nanoparticles have gained significant attention in healthcare applications such as gene therapy [42], cancer therapy [45], and diagnosis [48]. Polymeric nanoparticles can be synthesized from either natural polymers-such as chitosan and Poly(Llysine)-or synthetic polymers-such as Poly(lactideco-glycolide), polylactide acid, and poly(caprolactone) [78].…”

“…Therapeutic agents can be either encapsulated, dissolved, entrapped, or attached to the polymer matrix and surface of these nanoparticles [79]. For instance, Blakney et al reported a bioreducible, linear, cationic polymer, pABOL, for the delivery of self-amplifying mRNA that exhibits significantly less innate immunogenicity than traditional Polymeric nanoparticles PEI, PEG2000, hyperbranched bis-MPA polyester Gene editing therapy [42] Chitosan, ascorbic acid, penta-sodium tripolyphosphate Cervical cancer therapy [43] Poly (CBA-co-4-amino-1-butanol) (pABOL) Self-amplifying mRNA delivery [44] Dendrimers PAMAM, TNBSA Breast cancer therapy [45] PPI-m OS G4, Ara-CTP Drug delivery [46] PLLD-G4, HPG-C18 Gene delivery, Drug delivery [47] Micelles GE11 peptide, SPION, chitosan oligosaccharide MRI diagnosis [48] mPEG-PDLA Cancer therapy [49] LNPs [44]. Applications of polymeric nanoparticles are currently limited by low drug loading efficiency and reproducibility [80].…”