Targeted Molecular Imaging Probes Based on Magnetic Resonance Imaging for Hepatocellular Carcinoma Diagnosis and Treatment

Zhao, Dongxu; Cao, Jian; Zhang, Lei; Zhang, Shaohua; Wu, Song

doi:10.3390/bios12050342

Cited by 14 publications

(7 citation statements)

References 176 publications

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“…The inherent affinity of HA for CD44 proteins plays a critical role in developing sophisticated biosensors designed to detect its overexpression. The most conventional routes that employ HA-targeted imaging of cells include magnetic resonance(MR) [6], HA-PEI system [7], enzymelinked immunosorbent assays (ELISA) [8], and immunoelectrophoresis [9]. Though efficient, these techniques are often time-consuming and lab-oriented, requiring specific conditions for quantification.…”

Section: Introductionmentioning

confidence: 99%

Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins

et al. 2023

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The direct electrochemical detection of cancer biomarkers using single single‐component platforms is challenging. Herein, we propose constructing an efficient screen‐printed electrode (SPE) based platform for selective detection of CD44 proteins, a non‐kinase transmembrane glycoprotein. A sensing platform, MB‐MX/HA/SPE, was developed by incorporating few‐layered Ti3C2Tx nanosheets pre‐loaded with methylene blue (MB) dye. The nanosheets were subsequently immobilized with hyaluronic acid (HA), which served as a ligand for the specific recognition of CD44. The simple electrode configuration and the highly conductive Ti3C2Tx facilitated the electrochemical oxidation of MB, generating a reference SWV signal that declined proportionally with the increasing concentration of CD44 owing to ligand (HA)‐protein interaction. The sensor could register a sensitive inhibition response in the concentration range of 0.1 to 7.25 ng.mL−1 with a detection limit of 1.2×10−2 ng.mL−1 for CD44 proteins. Moreover, the synergistic combination of the highly conductive/adsorptive Ti3C2Tx nanosheets and hyaluronic acid (HA) led to strong antifouling characteristics even in the presence of other common proteins, such as bovine serum albumin (BSA), haemoglobin (Ig), immunoglobulin G (IgG), prostate‐specific antigen (PSA), and neuron‐specific enolase (NSE). The proposed strategy eliminates the need for additional components in the electrode modification procedure. In addition, incorporating MXenes as electrode material paves the way for developing sensitive biosensors with prospective applications in cancer diagnosis.

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Section: Introductionmentioning

confidence: 99%

Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins

et al. 2023

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“…Multimodal imaging techniques supported by nanotechnology harmonize the benefits of two or more imaging methods to counterbalance the imperfections of a single technique, providing a safer procedure for the positive diagnosis of HCC [34,35].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Nanomedicine: Photodynamic, Photothermal and Photoimmune Therapy in Hepatocellular Carcinoma: Fulfilling the Myth of Prometheus?

Ailioaie

Litscher³

2023

IJMS

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Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity and mortality, which seriously threatens the health and life expectancy of patients. The traditional methods of treatment by surgical ablation, radiotherapy, chemotherapy, and more recently immunotherapy have not given the expected results in HCC. New integrative combined therapies, such as photothermal, photodynamic, photoimmune therapy (PTT, PDT, PIT), and smart multifunctional platforms loaded with nanodrugs were studied in this review as viable solutions in the synergistic nanomedicine of the future. The main aim was to reveal the latest findings and open additional avenues for accelerating the adoption of innovative approaches for the multi-target management of HCC. High-tech experimental medical applications in the molecular and cellular research of photosensitizers, novel light and laser energy delivery systems and the features of photomedicine integration via PDT, PTT and PIT in immuno-oncology, from bench to bedside, were introspected. Near-infrared PIT as a treatment of HCC has been developed over the past decade based on novel targeted molecules to selectively suppress cancer cells, overcome immune blocking barriers, initiate a cascade of helpful immune responses, and generate distant autoimmune responses that inhibit metastasis and recurrences, through high-tech and intelligent real-time monitoring. The process of putting into effect new targeted molecules and the intelligent, multifunctional solutions for therapy will bring patients new hope for a longer life or even a cure, and the fulfillment of the myth of Prometheus.

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“…GPC-3 is overexpressed in liver cancer tissues, and only a small amount is expressed in healthy liver tissues. Therefore, GPC-3 can be used as an important immunotherapy target for liver cancer ( 7 ). In recent years, with the improvement of medical detection technology, an increasing number of scholars believe that the molecular typing of tumors is closely related to the formulation of treatment plans and prognosis.…”

Section: Introductionmentioning

confidence: 99%

The expression of Ki-67 and Glypican -3 in hepatocellular carcinoma was evaluated by comparing DWI and 18F-FDG PET/CT

Wang,

Li,

Wang

et al. 2023

Front. Oncol.

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ObjectiveThe value of DWI and 18F-FDG PET/CT in evaluating the expression of Ki-67 and GPC-3 in HCC was compared.Materials and methodsNinety-four patients with primary HCC confirmed by pathology were retrospectively divided into high- and low-Ki-67-expression groups and positive- and negative- GPC-3 groups. The ADC and SUVmax values of the lesions in both groups were measured. ROC curves were used to evaluate the identification efficiency of parameters with significant differences for each group of lesions, and AUCwas calculated. The combined ADC and SUVmax values were analyzed by binary logistic regression. The Delong test was used to compare the AUC values of the combined and single parameters. Pearson (in line with normal distribution) or Spearman (in line with abnormal distribution) correlation analysis was used to analyze the correlation.ResultsThe ADC value of the high-Ki-67-expression group was lower than that of the low-Ki-67-expression group (P<0.05), and the SUVmax value of the high-expression group was higher than that of the low-expression group (P<0.05). The ADC value of the positive-GPC-3 group was lower than that of the negative group (P<0.0.tive group (P<0.05). The combined ADC and SUVmax values in the GPC-3 group were better than those of a single parameter (P<0.05). There was a strong negative correlation between the SUVmax value and ADC value in the Ki-67 group (R=-0.578, P<0.001) and a weak negative correlation between the SUVmax value and ADC value in the GPC-3 group (R=-0.279, P=0.006). The SUVmax value was strongly positively correlated with the Ki-67 expression index (R=0.733, P<0.001), while the ADC value was strongly negatively correlated with the Ki-67 expression index (R=-0.687, P<0.001).ConclusionDWI and 18F-FDG PET/CT can be used to evaluate the expression of Ki-67 and GPC-3 in HCC, and there is a certain correlation between the ADC value and SUVmax. Combined DWI and 18F-FDG PET/CT is superior to a single technique in evaluating the expression of GPC-3 in HCC patients. However, the combined model did not benefit the Ki-67 group.

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Targeted Molecular Imaging Probes Based on Magnetic Resonance Imaging for Hepatocellular Carcinoma Diagnosis and Treatment

Cited by 14 publications

References 176 publications

Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins

Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins

Synergistic Nanomedicine: Photodynamic, Photothermal and Photoimmune Therapy in Hepatocellular Carcinoma: Fulfilling the Myth of Prometheus?

The expression of Ki-67 and Glypican -3 in hepatocellular carcinoma was evaluated by comparing DWI and 18F-FDG PET/CT

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Targeted Molecular Imaging Probes Based on Magnetic Resonance Imaging for Hepatocellular Carcinoma Diagnosis and Treatment

Cited by 14 publications

References 176 publications

Dye adsorbed few‐layer thick Ti3C2Tx‐MXenes for direct electrochemical detection of CD44 proteins

Dye adsorbed few‐layer thick Ti3C2Tx‐MXenes for direct electrochemical detection of CD44 proteins

Synergistic Nanomedicine: Photodynamic, Photothermal and Photoimmune Therapy in Hepatocellular Carcinoma: Fulfilling the Myth of Prometheus?

The expression of Ki-67 and Glypican -3 in hepatocellular carcinoma was evaluated by comparing DWI and 18F-FDG PET/CT

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Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins

Dye adsorbed few‐layer thick Ti₃C₂T_x‐MXenes for direct electrochemical detection of CD44 proteins