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Cited by 22 publications
(20 citation statements)
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References 9 publications
(31 reference statements)
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“…On the other hand, new studies have undermined this hypothesis by indicating that GDF11 concentration in serum does not decrease with age but, conversely, increases . In addition to this debate, the tissue source of GDF11 found in circulating blood remains unknown . We hypothesized that GDF11 could be stored in circulating platelets and also that serum may contain higher concentrations than plasma as a result of sample manipulation errors.…”
Section: Introductionmentioning
confidence: 93%
“…On the other hand, new studies have undermined this hypothesis by indicating that GDF11 concentration in serum does not decrease with age but, conversely, increases . In addition to this debate, the tissue source of GDF11 found in circulating blood remains unknown . We hypothesized that GDF11 could be stored in circulating platelets and also that serum may contain higher concentrations than plasma as a result of sample manipulation errors.…”
Section: Introductionmentioning
confidence: 93%
“…Emerging data indicate that the reversal of age-associated defects in stem cell stability and function could help to improve tissue maintenance and to prevent stem cell-derived carcinogenesis during aging (Patel & Demontis, 2014). Both stem cell-based interventions and other dietary and pharmacological interventions which induce stem cell-based regeneration and rejuvenation are likely to be very important for healthspan in the future, but are currently only beginning to be tested as modulators of lifespan in model organisms.…”
Section: Other Promising Potential Drugs and Drug Targetsmentioning
confidence: 99%
“…During aging, adult tissue stem cells exhibit impairments in functionality and exponential increases in premalignant mutations driven by cellintrinsic defects and alterations in the stem cell niche and the blood circulatory environment Behrens et al, 2014). Emerging data indicate that the reversal of age-associated defects in stem cell stability and function could help to improve tissue maintenance and to prevent stem cell-derived carcinogenesis during aging (Patel & Demontis, 2014). Both stem cell-based interventions and other dietary and pharmacological interventions which induce stem cell-based regeneration and rejuvenation are likely to be very important for healthspan in the future, but are currently only beginning to be tested as modulators of lifespan in model organisms.…”
Section: Stem Cellsmentioning
confidence: 99%
“…GDF11 shares much homology with myostatin, and myostatin is a negative regulator of muscle mass (McPherron 2010). Also the homologous gene myoglianin has been shown to preserve muscle function in fly aging models, together suggesting that GDF11 may preserve cardiac homeostasis and other tissues (Patel & Demontis 2014). …”
Section: Cardiac Aging Interventionsmentioning
confidence: 99%