Gdf-15 and Soluble St2 As Biomarkers of Right Ventricular Dysfunction in Pulmonary Hypertension

Keranov, Stanislav; Widmann, Laila; Jafari, Leili; Liebetrau, Christoph; Keller, Till; Troidl, Christian; Kriechbaum, Steffen; Voss, Sandra; Bauer, Pascal; Richter, Manuel J.; Tello, Khodr; Gall, Henning; Ghofrani, Hossein A.; Wiedenroth, Christoph B.; Guth, Stefan; Seeger, Werner; Hamm, Christian W.; Nef, Holger; Dörr, Oliver

doi:10.2217/bmm-2022-0395

Cited by 2 publications

(2 citation statements)

References 74 publications

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“…As a mitokine, levels of GDF15 are increased upon mitochondrial stress [23]. However, increased levels of GDF15 are found not only in primary mitochondrial disorders [24] but also in different diseases like neurodegenerative diseases [25], cardiovascular diseases [26], and cancer [27]. Furthermore, GDF15 is elevated in conditions like aging [28] or exercise [29].…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn’s Disease

Martín-Reyes,

Bernal,

Rodríguez-Díaz

et al. 2023

Antioxidants

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Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders of the gut. The incidence and activity of IBD are determined by both genetic and environmental factors. Among these factors, polymorphisms in genes related to autophagy and the consumption of non-steroidal anti-inflammatory drugs (NSAIDs) have been consistently associated with IBD. We show that NSAIDs induce mitochondrial stress and mitophagy in intestinal epithelial cells. In an altered mitophagy context simulating that observed in IBD patients, NSAID-induced mitochondrial stress leads to the release of mitochondrial components, which act as Danger Associated Molecular Patterns with pro-inflammatory potential. Furthermore, colonic organoids from Crohn’s disease patients and healthy donors show activation of the mitochondrial Unfolded Protein Response (UPRmt) upon treatment with ibuprofen. Finally, colon biopsies from Crohn’s disease patients in remission or with low-to-moderate activity also show expression of genes involved in UPRmt, while patients with severe activity show no increase compared to healthy donors. Our results suggest the involvement of mitochondria in the mechanisms triggering inflammation in IBD after NSAID use. Moreover, our results highlight the clinical relevance of mitochondrial stress and activation of the UPRmt pathway in the pathophysiology of Crohn’s disease.

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Section: Discussionmentioning

confidence: 99%

Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn’s Disease

Martín-Reyes,

Bernal,

Rodríguez-Díaz

et al. 2023

Antioxidants

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“…Levels of sST2 are elevated in patients with PAH of different etiologies compared to healthy controls and have been correlated with right ventricular dysfunction and hemodynamic impairment in patients in these patients [ 87 , 88 , 89 ]. In patients with IPAH a significant association was also found between sST2 and clinical worsening [ 90 ].…”

Section: St2 Involvement In Cardiovascular Diseasesmentioning

confidence: 99%

The ST2/IL-33 Pathway in Adult and Paediatric Heart Disease and Transplantation

et al. 2023

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ST2 is a member of interleukin 1 receptor family with soluble sST2 and transmembrane ST2L isoforms. The ligand of ST2 is IL-33, which determines the activation of numerous intracytoplasmic mediators following the binding with ST2L and IL-1RAcP, leading to nuclear signal and cardiovascular effect. Differently, sST2 is released in the blood and works as a decoy receptor, binding IL-33 and blocking IL-33/ST2L interaction. sST2 is mainly involved in maintaining homeostasis and/or alterations of different tissues, as counterbalance/activation of IL-33/ST2L axis is typically involved in the development of fibrosis, tissue damage, inflammation and remodeling. sST2 has been described in different clinical reports as a fundamental prognostic marker in patients with cardiovascular disease, as well as marker for the treatment monitoring of patients with heart failure; however, further studies are needed to better elucidate its role. In this review we reported the current knowledge about its role in coronary artery disease, heart failure, heart transplantation, heart valve disease, pulmonary arterial hypertension, and cardiovascular interventions.

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Gdf-15 and Soluble St2 As Biomarkers of Right Ventricular Dysfunction in Pulmonary Hypertension

Cited by 2 publications

References 74 publications

Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn’s Disease

Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn’s Disease

The ST2/IL-33 Pathway in Adult and Paediatric Heart Disease and Transplantation

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