GdCl3 catalysed Grieco condensation: A facile approach for the synthesis of novel pyrimidine and annulated pyrimidine fused indazole derivatives in single pot under mild conditions and their anti-microbial activity

Yakaiah, T.; Lingaiah, B. P. V.; Narsaiah, B.; Kumar, K. Pranay; Murthy, U. S. N.

doi:10.1016/j.ejmech.2007.03.031

Cited by 42 publications

(6 citation statements)

References 13 publications

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“…(Park et al, 2007). Yakaiah et al (2008) synthesized pyrimidine-fused indazole derivatives and screened them in vitro against Gram-positive, Gram-negative bacteria and fungal species such as yeast and filamentous fungi. The compound (27) showed potent activity with reference to penicillin as well as streptomycin.…”

Section: Indazoles As Antimicrobial Agentsmentioning

confidence: 99%

Indazole: a medicinally important heterocyclic moiety

et al. 2011

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This article reveals the various biological activities of the heterocyclic compound, indazole, including anti-inflammatory, antimicrobial, antiHIV, anticancer, hypoglycemic, antiprotozoal, antihypertensive, and other activities. From the observed biological activities of the indazole moiety, it is concluded that the medicinal properties of indazole have to be explored in the near future for the treatment of various pathological conditions.

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Section: Indazoles As Antimicrobial Agentsmentioning

confidence: 99%

Indazole: a medicinally important heterocyclic moiety

et al. 2011

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“…However, few studies have focused on the dehydrogenative C sp 2 –H cyanomethylation of heterocycles with bromoacetonitrile through visible-light catalysis . On the other hand, indazoles, an important class of N-heterocycles, play an important role in organic synthesis and medical chemistry exhibiting a wide range of biological activities such as antitumor, antimicrobial, anti-inflammatory, antiplatelet, and anticontraceptive activity while being also applied in HIV protease inhibition . Many strategies have been developed to synthesize such important molecules .…”

Section: Introductionmentioning

confidence: 99%

“… 9 On the other hand, indazoles, an important class of N-heterocycles, play an important role in organic synthesis and medical chemistry exhibiting a wide range of biological activities such as antitumor, antimicrobial, anti-inflammatory, antiplatelet, and anticontraceptive activity while being also applied in HIV protease inhibition. 10 Many strategies have been developed to synthesize such important molecules. 11 For example, the direct C3–H phosphonylation, amination, arylation, alkylation, and alkoxylation of 2 H -indazole by visible-light photoredox have been reported previously.…”

Section: Introductionmentioning

confidence: 99%

Visible-Light-Promoted Direct C3-H Cyanomethylation of 2H-Indazoles

Cui

Song

et al. 2023

ACS Omega

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“…Number of indazole derivatives, in particular, have already been reported to be excellent antibacterial and antimicrobial agents (Fig. 1) [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Evaluation of 3-Aryl Indazoles

Kola¹,

Kumar²,

Satish³

et al. 2022

JASR

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A series of 3-aryl indazoles 4a-4j were obtained by Pd catalyzed Suzuki coupling reaction. All the substrates were obtained in good yields under moderate reaction conditions. Next, the prepared compounds 4a-4j were screened for their antibacterial activity. The anti-bacterial activities of the prepared compounds were investigated against three bacterial strains i.e. Xanthomonas campestris, Escherichia coli, Bacillus megaterium. The anti-bacterial evaluation studies of these 3-aryl indazoles revealed that some of these test compounds possess moderate in vitro antibacterial activity.

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GdCl3 catalysed Grieco condensation: A facile approach for the synthesis of novel pyrimidine and annulated pyrimidine fused indazole derivatives in single pot under mild conditions and their anti-microbial activity

Cited by 42 publications

References 13 publications

Indazole: a medicinally important heterocyclic moiety

Indazole: a medicinally important heterocyclic moiety

Visible-Light-Promoted Direct C3-H Cyanomethylation of 2H-Indazoles

Synthesis and Antibacterial Evaluation of 3-Aryl Indazoles

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