Gd-EOB-DTPA enhanced MRI of the liver: Correlation of relative hepatic enhancement, relative renal enhancement, and liver to kidneys enhancement ratio with serum hepatic enzyme levels and eGFR

Talakić, Emina; Steiner, Jürgen; Kalmár, P.; Lutfi, Andre; Quehenberger, Franz; Reiter, Ursula; Fuchsjäger, Michael; Schöllnast, Helmut

doi:10.1016/j.ejrad.2013.12.010

Cited by 17 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Talakic et al assessed the correlation between RLE, relative renal enhancement, and liver‐to‐kidney enhancement ratio (LKR) with serum hepatic enzyme levels and enhanced green fluorescent protein (eGFR) in GA‐MRI of the liver . In this study, MR images were obtained before contrast injection, as well as during the early arterial, late arterial, venous, delayed, and 20‐min HBP after GA administration.…”

Section: Quantitative Methods For Evaluating Liver Function With Ga‐mrimentioning

confidence: 99%

“…The literature is replete with descriptions of quantitative methods for diagnosing and staging liver cirrhosis. Tamada et al found that hepatic parenchymal enhancement, i.e., RLE on CE‐MRI obtained using GA, is affected by the severity of cirrhosis . Verloh et al reported that RLE of the liver parenchyma is negatively affected by the increasing severity of liver cirrhosis, which, therefore, limits the value of the HBP for the diagnosis of hepatocellular carcinoma in patients with Child Pugh B and C cirrhosis .…”

Section: Potential Clinical Uses For Ga‐enhanced Mri Measures Of Livementioning

confidence: 99%

See 1 more Smart Citation

Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: Where are we?

Ba‐Ssalamah

Bastati

Wibmer

et al. 2016

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

Section: Quantitative Methods For Evaluating Liver Function With Ga‐mrimentioning

confidence: 99%

Section: Potential Clinical Uses For Ga‐enhanced Mri Measures Of Livementioning

confidence: 99%

Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: Where are we?

Ba‐Ssalamah

Bastati

Wibmer

et al. 2016

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Emina Talakic et al [32] also reached a similar conclusion that in the hepatobiliary phase, all serum liver enzymes were significantly related with RE, in addition TBIL and CHE showed the strongest correlation. Masahiro Okada et al [25] have found that when the activity of PT was greater than 86.9%, the Gd-EOB-DTPA enhanced MRI time can be shortened.…”

Section: Clinical Factors Affecting Gd-eob-dtpa Enhanced Mrimentioning

confidence: 64%

Advances in Assessing Preoperative Liver Function with Gd-EOB-DTPA Dynamic Contrast Enhanced MRI

Li¹,

Wang²,

Liu³

2019

View full text Add to dashboard Cite

Liver cancer is the common malignant tumor in China and current treatment is based on surgery. However, liver function of many liver cancer patients is impaired before surgery, so there's a high possibility of occurrence of liver failure after the tumor resection. Therefore, it's necessary to accurately evaluate liver function before surgery. Currently, clinical methods are mostly limited to assess the function of overall liver. But the application of hepatocyte-specific contrast agent-gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) makes it possible to assess the function of local liver segment accurately. This paper reviewed the progress of using Gd-EOB-DTPA dynamic contrast enhanced magnetic resonance imaging (MRI) to assess liver function preoperatively, such as parameters selection for liver function assessment, clinical factors affecting Gd-EOB-DTPA enhanced MRI and so on.

show abstract

“…In the ESGAR consensus statement, gadoxetate disodium is recommended for the diagnosis and characterization of malignant liver lesions in non-cirrhotic livers [23]. Aside from the associated higher costs, the relative hepatic enhancement could be negatively influenced by high serum bilirubin levels, which is common in patients with obstructive jaundice in pancreatic cancer of the head [24]. In this retrospective study, we evaluated the sensitivity of nonspecific extracellular gadolinium contrast-enhanced MRI (Gd-enhanced MRI) combined with DWI for synchronous liver metastases in potentially resectable pancreatic cancer on a 3T MR scanner.…”

Section: Introductionmentioning

confidence: 99%

Improving preoperative detection of synchronous liver metastases in pancreatic cancer with combined contrast-enhanced and diffusion-weighted MRI

et al. 2019

View full text Add to dashboard Cite

Purpose To explore the value of gadolinium-enhanced MRI combined with diffusion-weighted MRI (Gd-enhanced MRI with DWI) in addition to contrast-enhanced CT (CECT) for detection of synchronous liver metastases for potentially resectable pancreatic cancer. Methods By means of a retrospective cohort study we included patients with potentially resectable pancreatic cancer on CECT, who underwent Gd-enhanced MRI with DWI between January 2012 and December 2016. A single observer evaluated MRI and CT and was blinded to imaging, pathology, and surgery reports. Liver lesions were scored in both modalities, using a 3-point scale: 1-benign, 2-indeterminate, 3-malignant (i.e., metastasis). The primary outcome parameters were the presence of liver metastases on Gd-enhanced MRI with DWI and the sensitivity of Gd-enhanced MRI with DWI for synchronous liver metastases. Results We included 66 patients (42 men, 24 women; median age 65 years, range 36-82 years). In 19 patients, liver metastases were present, which were confirmed by histopathology (n = 12), 18 FDG-PET (n = 6), or surgical inspection (n = 1). Gd-enhanced MRI with DWI showed metastases in 16/19 patients (24%), which resulted in a sensitivity of 84% (95% CI 60-97%). Contrast-enhanced MRI showed 156 and DWI 397 metastases (p = 0.051), and 339 were particularly small (\ 5 mm). Conclusions In this study, Gd-enhanced MRI with DWI detected synchronous liver metastases in 24% of patients with potentially resectable pancreatic cancer on CECT with a sensitivity of 84%. Diffusion-weighted MRI showed a greater number of metastases than any other sequence, particularly small metastases (\ 5 mm).

show abstract

Gd-EOB-DTPA enhanced MRI of the liver: Correlation of relative hepatic enhancement, relative renal enhancement, and liver to kidneys enhancement ratio with serum hepatic enzyme levels and eGFR

Cited by 17 publications

References 21 publications

Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: Where are we?

Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: Where are we?

Advances in Assessing Preoperative Liver Function with Gd-EOB-DTPA Dynamic Contrast Enhanced MRI

Improving preoperative detection of synchronous liver metastases in pancreatic cancer with combined contrast-enhanced and diffusion-weighted MRI

Contact Info

Product

Resources

About