Hepatocellular carcinoma (HCC), which is one of the most common types of cancer worldwide, has been ranked as the third leading cause of cancer‑associated mortality worldwide. Rhotekin 2 (RTKN2), a Rho‑guanosine triphosphatase (GTPase) effector, has been reported to be anti‑apoptotic. However, the molecular mechanism underlying the biological function of RTKN2 in HCC is poorly defined. The current study reported that RTKN2 was overexpressed in 83% of HCC specimens compared with adjacent noncancerous tissues (n=30). Depletion of RTKN2 in HCC cells, HepG2 and BEL‑7404 by RNA interference led to marked inhibition of cell proliferation and cell cycle progression. Notably, RTKN2 silencing significantly reduced the levels of cell cycle‑associated proteins, proliferating cell nuclear antigen and cyclin‑dependent kinase 1. Additionally, it was identified that downregulation of RTKN2 in HCC cells notably induced cell apoptosis, while significantly repressing cell invasion. These data suggest that RTKN2 may act as an oncogene and inhibition of RTKN2 may be part of a novel therapeutic strategy for targeted HCC therapy.
Objective: Coronavirus disease 2019 (COVID-19) has caused considerable morbidity and mortality, especially in patients with underlying health conditions. A precise prognostic tool to identify poor outcomes
Under the background of carbon neutralization, developing the multi-energy system (MES), which effectively integrates kinds of energy resources, is one of the keys to solving the environmental contradiction. At present, considering heat storage, the research on the optimal scheduling of MES, especially industrial park MES, focuses on the heat storage tank. The potential of the heating supply network (HSN) for heat storage is underestimated and its operational constraints haven’t been fully studied. Therefore, with consideration of quantitative heat storage in HSN, a day-ahead operation scheduling optimization model for MES is proposed. The model proposes a tubular heat storage body (THSB) to describe the heat storage characteristics and charge/discharge constraints of HSN and studies its impact on economic benefits and stability of output power. Equivalent method is used to quantify the heat storage capacity of HSN. Based on the established model, we take a real industrial park to optimize the operation plan of heating conditions in winter. Results indicate that the optimized scenario shows better economic benefits and output stability, which saves 1,303 yuan of operation cost per day.
Objective: To study the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous acetic acid injection (PAI) on massive hepatocellular carcinoma (MHCC). Methods: TACE was performed in 57 patients with MHCC, which were randomly divided into group A (n = 28) and group B (n = 29). Patients in the group A received conventional TACE for the first time and then received low dose TACE (10 mg mitomycin C) for the repeated treatment, Re-examined CT scans after TACE for a week. Based on filled status of Lipiodol in the Lesions, PAI was underwent in the area of rarefaction or defect filled by Lipiodol. Patients in the group B received conventional TACE. Then The survival rate and masses variation Results: The 1-, 2-and 3-year survival rate after TACE were 96.4%, 78.6% and 32.1% for group A, and 65.5%, 48.3% and 20.7% for group B. Masses diminution were found in all patients in group A, while 20 cases were found in group B, unchanged in 5 cases and enlarged in 4 cases. Conclusion: The efficacy of TACE combined with PAI are significantly better than that of TACE only, low dose TACE produces less hepatic damage and less side effect.
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