Gd-DTPA-dialkylamine derivatives: Synthesis and self-assembled behaviors for T1-enhanced magnetic resonance imaging and drug carriers

CT/MR Dual-Modality Imaging Tracking of Mesenchymal Stem Cells Labeled with a Au/GdNC@SiO2 Nanotracer in Pulmonary Fibrosis

“…To evaluate whether the Au/GdNC@SiO 2 could act as a valid MRI nanotracer, the longitudinal ( T 1 ) relaxation time was measured with a 0.5 T NMR analyzer at different Gd concentrations. As presented in Figure E, the Au/GdNC showed a high r 1 value of 8.68 s –1 per mM of Gd in PBS, from the linear fitting of the plot of 1/ T 1 vs Gd concentration, which was nearly twice as large as that of Magnevist (3.80 mM –1 s –1 ), one of the most widely used MRI contrast agents in the clinic . Interestingly, Au/GdNC@SiO 2 exhibited a substantially higher value of r 1 (24.62 mM –1 s –1 ) than Au/GdNC (8.68 mM –1 s –1 ) (Figure F).…”

“…As presented in Figure 3E, the Au/GdNC showed a high r 1 value of 8.68 s −1 per mM of Gd in PBS, from the linear fitting of the plot of 1/T 1 vs Gd concentration, which was nearly twice as large as that of Magnevist (3.80 mM −1 s −1 ), one of the most widely used MRI contrast agents in the clinic. 37 Interestingly, Au/GdNC@SiO 2 exhibited a substantially higher value of r 1 (24.62 mM −1 s −1 ) than Au/GdNC (8.68 mM −1 s −1 ) (Figure 3F). The dramatically increased relaxivity might be due to the formation of Au/GdNC aggregates encapsulated by the silica shell.…”

“…It takes periods spanning several weeks for stem cells to exhibit their treatment efficacy, so the nanotracers are required to trace the transplanted MSCs in quite a long period . Gold nanomaterials are ideal CT nanotracers for MSC tracking due to their strong X-ray absorption coefficient (5.16 cm 2 g –1 at 100 keV), good colloidal stability and biocompatibility, sustained contrast, shape and size controllability, surface modifiability, and little adverse effects on the labeled MSCs. ,− Furthermore, gadolinium (Gd) also absorbs X-ray radiation 2.5 times more than iodine, a widely used CT contrast agent in the clinic, , making it a promising candidate for CT imaging. , Integrating Au and Gd into a single scaffold, it is expected, may produce synergistic effects, leading to a better CT imaging contrast than either Au or Gd alone. , Meanwhile, Gd is a superior MRI nanotracer for cell tracking . Thus, the combination of the two elements into a single nanoplatform may offer a potential strategy to realize CT/MR dual-modality imaging tracing of the stem cells after transplantation into the lung.…”

“…35,36 Meanwhile, Gd is a superior MRI nanotracer for cell tracking. 37 Thus, the combination of the two elements into a single nanoplatform may offer a potential strategy to realize CT/MR dual-modality imaging tracing of the stem cells after transplantation into the lung.…”

A literature review on multimodality molecular imaging nanoprobes for cancer detection

“…In two studies [73,81] lack of using nanoparticle technology was predicted by researchers. As well as Hui Fang et al [82] introduced Gd-DTPA-N16-16 to enhance the intensity of T 1 relaxation times in the liver and kidneys of mice. They also loaded doxorubicin (DOX) into the hydrophilic cavity of vesicles and showed theranostic applications and anti-tumor effects of the DOX-loaded Gd-DTPA-N16-16 vesicles against MCF-7 cancer cells.…”