A traceable, GSH/pH dual-responsive nanoparticles with spatiotemporally controlled multiple drugs release ability to enhance antitumor efficacy

Wang, Ning; Liu, Chenyu; Yao, Weihe; Zhou, Haibin; Yu, Simiao; Chen, Hailiang; Qiao, Weihong

doi:10.1016/j.colsurfb.2021.111866

Cited by 13 publications

(16 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, constructing a multifunctional pH-responsive NDDS provides an effective strategy for chemotherapy. Wang et al ( 157 ) synthesized multifunctional NPs (FTDCAG NPs), using a pH-responsive prodrug (PEG2K-NH-N-DOX), a GSH-responsive prodrug (PEG2K-S-S-CPT), folate-receptor targeting polymers (FA-PEG2K-L8, FA-PEG2K-TOS), and T1-enhanced magnetic resonance imaging contrast agents (Gd-DTPA-N16-16) used to encapsulate combrestatin A4 (CA4). These FTDCAG NPs contained three drugs, namely, CA4, DOX, and CPT.…”

Section: Application Of Ph-responsive Polymer Nanomaterials In Tumor ...mentioning

confidence: 99%

pH-Responsive Polymer Nanomaterials for Tumor Therapy

et al. 2022

View full text Add to dashboard Cite

The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals of the tumor microenvironment, various stimuli-responsive drug delivery systems can be constructed for targeted drug delivery to tumor sites. Among these, the pH is frequently utilized, owing to the pH of the tumor microenvironment being lower than that of blood and healthy tissues. pH-responsive polymer carriers can improve the efficiency of drug delivery in vivo, allow targeted drug delivery, and reduce adverse drug reactions, enabling multifunctional and personalized treatment. pH-responsive polymers have gained increasing interest due to their advantageous properties and potential for applicability in tumor therapy. In this review, recent advances in, and common applications of, pH-responsive polymer nanomaterials for drug delivery in cancer therapy are summarized, with a focus on the different types of pH-responsive polymers. Moreover, the challenges and future applications in this field are prospected.

show abstract

Section: Application Of Ph-responsive Polymer Nanomaterials In Tumor ...mentioning

confidence: 99%

pH-Responsive Polymer Nanomaterials for Tumor Therapy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The 1 H NMR hydrogen spectrum of G3 NH 2 -β-CD was recorded using a Bruker AV Ⅲ 500 MHz NMR spectrometer ( Wang et al, 2021 ). The FT-IR spectra of the G3.…”

Section: Methodsmentioning

confidence: 99%

“…The size distribution and zeta potentials of the targeted drug-loaded nanocomposite suspensions were measured by the dynamic light scattering (DLS) technique using a Nano-ZS 90 Zetasizer (Malvern, America) at 25°C. The zeta potential (ζ) was determined by using laser Doppler electrophoresis (LDE) ( Qiu et al, 2018 ; Wang et al, 2021 ). In vitro CT images of each concentration of the NPs (0.005, 0.01, 0.02, 0.04, 0.08, and 0.16 M) were captured using a single-source CT imaging system (Aquilion ONE 320 CT, Canon Medical Systems).…”

Section: Methodsmentioning

confidence: 99%

β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for Improving Drug Delivery to the Inner Ear

Luo

Lin

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Here, we developed a safe and highly effective nanocarrier using β-cyclodextrin (β-CD) and oligoarginine peptide (Arg8)-modified dendrimer-entrapped gold nanoparticles (Au@CD-PAMAM-Arg8), with a diameter of 5 nm, for improved delivery of dexamethasone (Dex) to the inner ear. The properties and in vivo distribution of the Au@CD-PAMAM-Arg8 were assessed in vitro, and a streptomycin (SM) ototoxicity model was used in vivo. Flow cytometry analysis of HEIOC1 cells treated with Au@CD-PAMAM-Arg8 and Au @CD-PAMAM at different time intervals indicated that cell uptake efficiency of the drug delivery carrier Au@CD-PAMAM-Arg8 was higher than that of Au @CD-PAMAM. Au@CD-PAMAM-Arg8 carrying Dex (Au@CD-PAMAM-Arg8/Dex) were mainly distributed in hair cells, the spiral ganglion, lateral wall, and nerve fibers and had stronger protective effects on the inner ear than Dex administration alone. In vivo tracer tests revealed that tympanic injection was significantly more effective than posterior ear injection, muscle injection, and tail vein injection, whereas clinical retro-auricular injection could not increase the efficiency of drug delivery into the ear. Electrocochleography results showed that Au@CD-PAMAM-Arg8/Dex significantly improved hearing in C57/BL6 mice after SM exposure. These findings indicate that Au@CD-PAMAM-Arg8 may be the useful drug carriers for the treatment of inner ear diseases.

show abstract

“…[ [116][117][118][119][120][121][122] PEG-PEI-GEM polyethylenimine-graft-poly(ethylene glycol)gemcitabine pH Light…”

Section: Combination Of Various Stimuli For Polymersmentioning

confidence: 99%

“…In recent years, the combination of GSH concentration and pH has gained importance in the drug delivery field [117][118][119][120]122,140]. Wang et al created dual-responsive polymeric nanoparticles based on pH and GSH concentration to deliver multiple drugs in cancerous environments [121]. The disulfide bond connecting poly(ethylene glycol) (PEG) and camptothecin (CPT), a chemotherapeutic drug, allows for the release at high concentrations of GSH (Figure 13), while the NH-N bond between PEG and doxorubicin (DOX), another chemotherapeutic drug, allows for the breaking of the hydrazine bond in acidic environments.…”

Section: Ph/redox-responsive Polymersmentioning

confidence: 99%

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

2022

View full text Add to dashboard Cite

Polymers that can change their properties in response to an external or internal stimulus have become an interesting platform for drug delivery systems. Polymeric nanoparticles can be used to decrease the toxicity of drugs, improve the circulation of hydrophobic drugs, and increase a drug’s efficacy. Furthermore, polymers that are sensitive to specific stimuli can be used to achieve controlled release of drugs into specific areas of the body. This review discusses the different stimuli that can be used for controlled drug delivery based on internal and external stimuli. Internal stimuli have been defined as events that evoke changes in different characteristics, inside the body, such as changes in pH, redox potential, and temperature. External stimuli have been defined as the use of an external source such as light and ultrasound to implement such changes. Special attention has been paid to the particular chemical structures that need to be incorporated into polymers to achieve the desired stimuli response. A current trend in this field is the incorporation of several stimuli in a single polymer to achieve higher specificity. Therefore, to access the most recent advances in stimuli-responsive polymers, the focus of this review is to combine several stimuli. The combination of different stimuli is discussed along with the chemical structures that can produce it.

show abstract

A traceable, GSH/pH dual-responsive nanoparticles with spatiotemporally controlled multiple drugs release ability to enhance antitumor efficacy

Cited by 13 publications

References 28 publications

pH-Responsive Polymer Nanomaterials for Tumor Therapy

pH-Responsive Polymer Nanomaterials for Tumor Therapy

β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for Improving Drug Delivery to the Inner Ear

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

Contact Info

Product

Resources

About