Gd‐Based Mesoporous Silica Nanoparticles as MRI Probes

Carniato, Fabio; Tei, Lorenzo

doi:10.1002/ejic.201801039

Cited by 45 publications

(43 citation statements)

References 113 publications

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“…Recently, Carniato et al summarised the most remarkable examples of Gd-based mesoporous silica nanoparticles for MRI. In this work, the influence over the relaxometric properties of important factors such as the porosity, the localisation of the paramagnetic chelate and the surface properties of the mesoporous silica nanoparticles are discussed in detail [45]. For instance, Davis et al reported mesoporous silica nanoparticles doped with Gd in the inner or outer part of the pore and in the surface of the particle showing great differences in the relaxivity values depending on the Gd localisation [46].…”

Section: Silica Based Nanoparticlesmentioning

confidence: 97%

Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

et al. 2020

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Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities.

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Section: Silica Based Nanoparticlesmentioning

confidence: 97%

Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

et al. 2020

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“… Irrespective of the functionalization methods, with the choice of organosilanes, the charge, hydrophobicity and textural properties of silica can be tailored. Thus, selecting a right organosilane is very important In comparison, co‐condensation offers the homogeneous distribution of functional groups in high loading on silica. Maintaining pH is important during the functionalization of silica by co‐condensation as it has the influence on the rate of condensation and size of silica particles …”

Section: Methods Of Silica Functionalizationmentioning

confidence: 99%

“…: sol‐gel method) undergoes effective functionalization as it has more silanol groups. The ability of different silanol groups to undergo functionalization is in the following order: hydrogen bonded silanols>geminal silanols>isolated silanols. Locating three neighbouring surface silanols close enough to bond with the same silane is very difficult due to the steric and strain effects. Hence, mono and bi‐podal anchoring of functional groups seem to be more realistic. While preparing functionalized mesoporous silicas (especially through co‐condensation), size and concentration of organosilanes are the key factors influencing the fundamental porous structure of mesoporous silicas …”

Section: Methods Of Silica Functionalizationmentioning

confidence: 99%

Functionalized Silicas for Metal‐Free and Metal‐Based Catalytic Applications: A Review in Perspective of Green Chemistry

Antony

Marimuthu

Yang

et al. 2019

The Chemical Record

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Heterogeneous catalysis plays a key role in promoting green chemistry through many routes. The functionalizable reactive silanols highlight silica as a beguiling support for the preparation of heterogeneous catalysts. Metal active sites anchored on functionalized silica (FS) usually demonstrate the better dispersion and stability due to their firm chemical interaction with FSs. Having certain functional groups in structure, FSs can act as the useful catalysts for few organic reactions even without the need of metal active sites which are termed as the covetous reusable organocatalysts. Magnetic FSs have laid the platform where the effortless recovery of catalysts is realized just using an external magnet, resulting in the simplified reaction procedure. Using FSs of multiple functional groups, we can envisage the shortened reaction pathway and, reduced chemical uses and chemical wastes. Unstable bio‐molecules like enzymes have been stabilized when they get chemically anchored on FSs. The resultant solid bio‐catalysts exhibited very good reusability in many catalytic reactions. Getting provoked from the green chemistry aspects and benefits of FS‐based catalysts, we confer the recent literature and progress focusing on the significance of FSs in heterogeneous catalysis. This review covers the preparative methods, types and catalytic applications of FSs. A special emphasis is given to the metal‐free FS catalysts, multiple FS‐based catalysts and magnetic FSs. Through this review, we presume that the contribution of FSs to green chemistry can be well understood. The future perspective of FSs and the improvements still required for implementing FS‐based catalysts in practical applications have been narrated at the end of this review.

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“…The paramagnetic nanoparticles proposed in the literature are composed using a diamagnetic inorganic support functionalized with Gd(III)-chelates, opportunely modified to promote their chemical attachment on the surface [5][6][7][8][9][10]; or they are completely inorganic [11,12]. In the last case, the particles contain directly in the framework paramagnetic Gd 3+ ions, often combined with other lanthanides with specific properties [11].…”

Section: Introductionmentioning

confidence: 99%

1H NMR Relaxometric Analysis of Paramagnetic Gd2O3:Yb Nanoparticles Functionalized with Citrate Groups

Carniato

Gatti

2019

Inorganics

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Gd2O3 nanoparticles doped with different amount of Yb3+ ions and coated with citrate molecules were prepared by a cheap and fast co-precipitation procedure and proposed as potential “positive” contrast agents in magnetic resonance imaging. The citrate was used to improve the aqueous suspension, limiting particles precipitation. The relaxometric properties of the samples were studied in aqueous solution as a function of the magnetic field strength in order to evaluate the interaction of the paramagnetic ions exposed on the surface with the water molecules in proximity. The nanoparticles showed high relaxivity values at a high magnetic field with respect to the clinically used Gd3+-chelates and comparable to those of similar nanosytems. Special attention was also addressed to the investigation of the chemical stability of the nanoparticles in biological fluid (reconstructed human serum) and in the presence of a chelating agent.

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Gd‐Based Mesoporous Silica Nanoparticles as MRI Probes

Cited by 45 publications

References 113 publications

Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Functionalized Silicas for Metal‐Free and Metal‐Based Catalytic Applications: A Review in Perspective of Green Chemistry

1H NMR Relaxometric Analysis of Paramagnetic Gd2O3:Yb Nanoparticles Functionalized with Citrate Groups

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