GC-MS analysis of allergens in plant oils meant to cosmetics

Kaloustian, J.; Mikail, Céline; El‐Moselhy, Tarek F.; Abou, Lydia; Portugal, Henri

doi:10.1051/ocl.2007.0103

Cited by 12 publications

(7 citation statements)

References 38 publications

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“…This ion source proved suitable for the selective ionization of analytes by optimizing the wavelength of the light source, and the obtained limit of detection (LOD) values were all below 100 pg/μL. In fragrance analysis, GC was interfaced/coupled usually with quadrupoles (Q) [ 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 ], ion traps (IT) [ 153 , 157 , 185 , 186 , 187 ], and a few cases with time-of-flight (TOF) [ 148 , 188 ] mass analyzers, and in some situations, MS/MS analysis was also performed [ 107 , 189 ] for fragrance fingerprints. MS data acquisition was achieved typically in scan mode (full scan mode in different mass ranges) [ 190 ] selected ion monitoring (SIM)—in order to distinguish target fragrance, with known MS features and maximum sensitivity, making it ideal for quantification and validation [ 31 , 107 , 152 , 155 , 156 , 158 , 159 , 160 , 163 , 165 , 170 , 188 ], selected reaction monitoring (SRM)/multiple reaction monitoring (MRM) (resulting in increased selectivity, sensitivity, and signal/noise ratio [ 107 , 189 ...…”

Section: Ms Analysis Of Cosmetic Ingredientsmentioning

confidence: 99%

Mass-Spectrometry-Based Research of Cosmetic Ingredients

Serb,

Georgescu,

Onulov

et al. 2024

Molecules

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Cosmetic products are chemical substances or mixtures used on the skin, hair, nails, teeth, and the mucous membranes of the oral cavity, whose use is intended to clean, protect, correct body odor, perfume, keep in good condition, or change appearance. The analysis of cosmetic ingredients is often challenging because of their huge complexity and their adulteration. Among various analytical tools, mass spectrometry (MS) has been largely used for compound detection, ingredient screening, quality control, detection of product authenticity, and health risk evaluation. This work is focused on the MS applications in detecting and quantification of some common cosmetic ingredients, i.e., preservatives, dyes, heavy metals, allergens, and bioconjugates in various matrices (leave-on or rinse-off cosmetic products). As a global view, MS-based analysis of bioconjugates is a narrow field, and LC- and GC/GC×GC-MS are widely used for the investigation of preservatives, dyes, and fragrances, while inductively coupled plasma (ICP)-MS is ideal for comprehensive analysis of heavy metals. Ambient ionization approaches and advanced separation methods (i.e., convergence chromatography (UPC2)) coupled to MS have been proven to be an excellent choice for the analysis of scented allergens. At the same time, the current paper explores the challenges of MS-based analysis for cosmetic safety studies.

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Section: Ms Analysis Of Cosmetic Ingredientsmentioning

confidence: 99%

Mass-Spectrometry-Based Research of Cosmetic Ingredients

Serb,

Georgescu,

Onulov

et al. 2024

Molecules

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“…Fragrance compounds, which can be found in natural essential oils or produced synthetically, can cause allergic contact dermatitis [163]. In the case of limonene and linalool, oxidized derivatives, such as peroxides, are responsible for the allergenic action [164]. Limonene and linalool are chiral molecules and one of the presences of those enantiomers is leading to cause allergenic action.…”

Section: Involvement Of Chirality In Cosmeticsmentioning

confidence: 99%

Chirality: An inescapable concept for the pharmaceutical, bio‐pharmaceutical, food, and cosmetic industries

Kandula

Rayala

Radhakrishnanand

2023

Separation Science Plus

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Chirality resides in diverse fields such as pharmaceuticals, food, bio‐pharmaceuticals, and cosmetics. Drugs used in treating various disease conditions, the majority of the plant secondary metabolites, various chemicals used in cosmetics, and distinct flavoring agents used in food industries exhibit chirality. In this context, there is an obligation to extend the analysis to chiral aspects. Attempts have been made to summarize the systematic, successful approaches for enantiomeric production via both enantio‐selective synthesis and the resolution of enantiomers using various analytical techniques including crystallization, chiral chromatography, capillary electrophoresis, kinetic resolution mediated by enzymes. Efforts have also been made to describe the regulatory guidance regarding bridging studies in the milieu of chiral switching. The majority of the monoclonal antibodies, growth factors, blood components, deoxyribonucleic acids, enzymes, and even vaccines for various diseases like cancer, polio, malaria, tetanus, hepatitis B, cholera, diphtheria bind differently to the receptors because the majority of drug binding and antibody binding receptors are also exhibiting chirality. Recent advancements in the various analytical techniques involved in the chiral analysis of food to preserve the authenticity of distinct flavors and cosmetics to identify safer enantiomers and reduce side effects both to humans and the environment are described.

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“…It indicated that the lyrame formation was not completion. Lyral has two E-Z isomer configurating at its cyclic structure which shown in Figure 5 12 .…”

Section: Gc-ms Chromatogram Of Lyrame's Synthesismentioning

confidence: 99%

Synthesis and Mass Spectrum Characterization of Lyrame Schiff Base for Synthetic Ingredients in Perfumes Industry

et al. 2018

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Fragrance was a common material in human daily life. It has unique property, especially in odor. Lyrame was a synthetic precursor that was added to fragrance to increase fragrance stability and make odor last longer. Lyrame can be synthesized by using simple condensation method. This method was effective and low cost. The synthesis of lyrame uses lyral and methyl anthranilate as a precursor. The weighting methyl anthranilate was mixed to lyral solution, then heated and stirred at temperature 110 ± 50C for 30 minutes. The characterization of lyrame comprised organoleptics test and chemical structure. The organoleptics for product was color test. The chemical structure was analyzed by gas chromatography-mass spectrometry (GC-MS). Based on result from experiment, color of lyrame product was light yellow. The color of product depends on time of synthesis and concentration of precursor. The mass fragmentation pattern exhibiting the lyrame has been synthesized successfully.

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GC-MS analysis of allergens in plant oils meant to cosmetics

Cited by 12 publications

References 38 publications

Mass-Spectrometry-Based Research of Cosmetic Ingredients

Mass-Spectrometry-Based Research of Cosmetic Ingredients

Chirality: An inescapable concept for the pharmaceutical, bio‐pharmaceutical, food, and cosmetic industries

Synthesis and Mass Spectrum Characterization of Lyrame Schiff Base for Synthetic Ingredients in Perfumes Industry

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