GC/MS analysis, and antioxidant and antimicrobial activities of alkaloids extracted by polar and apolar solvents from the stems of Anabasis articulata

Belyagoubi-Benhammou, Nabila; Belyagoubi, Larbi; Gismondi, Angelo; Marco, Gabriele Di; Canini, Antonella; Bekkara, Fawzia Atik

doi:10.1007/s00044-019-02332-6

Cited by 46 publications

(26 citation statements)

References 20 publications

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“…The overall findings supported the hypothesis that caffeine may potentially regulate oxidative stress, neuroinflammation, and synaptic dysfunctions in LPS-injected mouse brains. The protective effects of caffeine against LPS-induced oxidative damage [36] may be possibly due to it regulating the levels of superoxide dismutase, glutathione peroxidase, and catalase [36,37,38]. Our findings, together with the previous reports [27], suggest that caffeine may reduce elevated oxidative stress, neuroinflammation, and synaptic dysfunction in the LPS-injected mouse brains.…”

Section: Discussionsupporting

confidence: 75%

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

et al. 2019

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Herein, we assayed the antioxidant and anti-inflammatory potential of caffeine in a lipopolysaccharide (LPS)-injected mouse model of neurodegeneration and synaptic impairment. For this purpose, LPS was injected for two weeks on an alternate-day basis (250 µg/kg/i.p. for a total of seven doses), while caffeine was injected daily for four weeks (30 mg/kg/i.p/four weeks). According to our findings, there was a significant increase in the level of reactive oxygen species (ROS), as evaluated from the levels of lipid peroxidation (LPO) and ROS assays. Also, we evaluated the expression of nuclear factor erythroid-2-related factor 2 (Nrf2) and the enzyme hemeoxygenase 1 (HO-1) in the mouse groups and found reduced expression of Nrf2 and HO-1 in the LPS-treated mice brains, but they were markedly upregulated in the LPS + caffeine co-treated group. We also noted enhanced expression of toll-Like Receptor 4 (TLR4), phospho-nuclear factor kappa B (p-NF-kB), and phospho-c-Jun n-terminal kinase (p-JNK) in the LPS-treated mice brains, which was significantly reduced in the LPS + caffeine co-treated group. Moreover, we found enhanced expression of Bcl2-associated X, apoptosis regulator (Bax), and cleaved caspase-3, and reduced expression of B-cell lymphoma 2 (Bcl-2) in the LPS-treated group, which were markedly reversed in the LPS + caffeine co-treated group. Furthermore, we analyzed the expression of synaptic proteins in the treated groups and found a marked reduction in the expression of synaptic markers in the LPS-treated group; these were significantly upregulated in the LPS + caffeine co-treated group. In summary, we conclude that caffeine may inhibit LPS-induced oxidative stress, neuroinflammation, and synaptic dysfunction.

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Section: Discussionsupporting

confidence: 75%

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

et al. 2019

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“…The extracts and their combinations showed potent DPPH scavanging potential. However, the extract may contain other metabolites also, and these can also contribute to antioxidant activity (Belyagoubi-Benhammou et al 2019). The antioxidant activity of herbal extract could also be associated to its flavonoid content.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Sharma

Baboota

Amin

et al. 2020

Pharmaceutical Biology

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Context: Nephrotoxicity is a renal dysfunction that arises from direct exposure to environmental chemicals or as a side effect of therapeutic drugs. Boerhaavia diffusa Linn. (Nyctaginaceae), Rheum emodi Wall. Ex. Meissn. (Polygonaceae), Nelumbo nucifera Gaertn. (Nelumbonaceae) and Crataeva nurvala Buch-Ham. (Capparidaceae) are well-recognized medicinal plants of Indian traditional system of medicine used for kidney disorders.Objectives: The present investigation was undertaken to develop a chromatographically characterized polyherbal combination and to evaluate its nephroprotective activity. Materials and methods: Roots of B. diffusa and R. emodi, flowers of N. nucifera and stem bark of C. nurvala were extracted by decoction using 70% ethanol. Response surface methodology (RSM) was used for the optimization of extraction parameters. Polyherbal combinations with different doses (150-300 mg/kg) were tested against methotrexate-induced nephrotoxicity in Wistar rats. Results: The optimized extract contained 27% phenols and 15% flavonoids, which showed 75% 1, 1diphenyl-2-picryl-hydrazyl (DPPH) scavenging potential. Based on the retention time of high-performance liquid chromatography (HPLC) analysis, 17 out of 122 constituents were found common in all extracts and combinations. Two combinations showed significantly higher (p 0.05) DPPH scavenging potential and xanthine oxidase inhibition. The half maximal inhibitory concentration (IC 50 ) of the best combination for DPPH scavenging and xanthine oxidase inhibition were 80 and 74 mg/mL, respectively. Treatment of methotrexate-induced nephrotoxic rats with polyherbal combination significantly (p 0.05) improved the kidney function markers, oxidative stress markers and histological parameters. Discussion and conclusion: The developed combination was found to be effective in nephrotoxicity; it can be explored further for the management of drug-induced nephrotoxicity and other chronic kidney diseases. ARTICLE HISTORY

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“…Besides the above‐mentioned mono‐indole‐containing alkaloids, several other indole‐containing alkaloids were also isolated from various natural sources, but all of them were inactive or only displayed a weak activity against the tested bacteria. [ 56–93 ] For example, paraherquamide J ( 30 ), a new prenylated indole‐containing alkaloid from the marine‐derived fungus Penicillium janthinellum HK1–6, was devoid of activity against both Gram‐positive ( S. aureus , E. faecalis , and E. faecium ) and Gram‐negative ( E. coli ) pathogens. [ 93 ]…”

Section: Mono‐indole‐containing Alkaloidsmentioning

confidence: 99%

Natural indole‐containing alkaloids and their antibacterial activities

Liu

Cui

et al. 2020

Archiv der Pharmazie

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As the growth in resistance to bacterial infection treatments poses a grave threat to global health in the 21st century, there is a constant need to explore novel antibacterial agents that have the ability to overcome drug resistance. Indole-containing alkaloids are widely distributed in nature, and a variety of indole-containing alkaloids have already been applied in clinical practice, proving that indole-containing alkaloids are fascinating and privileged scaffolds for the development of novel drugs. Moreover, indole

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GC/MS analysis, and antioxidant and antimicrobial activities of alkaloids extracted by polar and apolar solvents from the stems of Anabasis articulata

Cited by 46 publications

References 20 publications

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Natural indole‐containing alkaloids and their antibacterial activities

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