Natural indole‐containing alkaloids and their antibacterial activities

Liu, Yang; Cui, Ying; Lu, Liyan; Gong, Yufeng; Han, Wen Bo; Gui-shun, Piao

doi:10.1002/ardp.202000120

Cited by 46 publications

(37 citation statements)

References 99 publications

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“…They are mainly distributed in Loganaceae, Apocynaceae, Rubiaceae Juss., and other plant groups. Based on their core structures, they are mainly divided into monomeric indole alkaloids, tryptamine indole alkaloids, monoterpenoid indole alkaloids, and bis-indolic alkaloids [ 8 , 12 ].…”

Section: Antibacterial Activity Of Different Types Of Natural Alkamentioning

confidence: 99%

“…Berberine inhibits E. coli by negatively regulating the FtsZ protein [ 81 ]. Indole alkaloids can be used as potential drug resistance reversal agents that exert antibacterial activity by inhibiting FtsZ and MRSA pyruvate kinase [ 12 ].…”

Section: Antibacterial Mechanisms Of Natural Alkaloidsmentioning

confidence: 99%

“…Based on their different chemical structures, alkaloids can be divided into isoquinolines, pyrroles, pyridines, quinolines, indoles, and ten other types of alkaloids [ 8 ]. Several in vivo and clinical investigations have reported that alkaloids have various pharmacological effects, including anticancer [ 9 ], antiviral [ 10 ], anti-inflammatory [ 11 ], and antibacterial activities [ 12 ]. Due to their extensive pharmacological activities, many alkaloid drugs have been developed, such as morphine as a narcotic analgesic [ 13 ], the cough medicine codeine [ 14 ], the anticancer drug vinblastine [ 15 ], and antibacterial drug berberine hydrochloride [ 16 ], all of which are widely used in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

et al. 2021

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Alkaloids are nitrogen-containing heterocyclic compounds typically isolated from plants. They represent one of the most important types of natural products because of their large number and structural diversity and complexity. Based on their chemical core structures, alkaloids are classified as isoquinolines, quinolines, indoles, piperidine alkaloids, etc. In-depth analyses of alkaloids have revealed their antibacterial activities. To date, due to the widespread use of antibiotics, the problem of drug-resistant bacterial infections has been gradually increasing, which severely affects the clinical efficacy of antibacterial therapies and patient safety. Therefore, significant research efforts are focused on alkaloids because they represent a potentially new type of natural antibiotic with a wide antibacterial spectrum, rare adverse reactions, and a low tendency to produce drug resistance. Their main antibacterial mechanisms include inhibition of bacterial cell wall synthesis, change in cell membrane permeability, inhibition of bacterial metabolism, and inhibition of nucleic acid and protein synthesis. This article reviews recent reports about the chemical structures and the antibacterial activities and mechanisms of alkaloids. The purpose is to solve the problem of bacterial resistance and to provide a certain theoretical basis and research ideas for the development of new antibacterial drugs.

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Section: Antibacterial Activity Of Different Types Of Natural Alkamentioning

confidence: 99%

Section: Antibacterial Mechanisms Of Natural Alkaloidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

et al. 2021

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“…Indole derivatives with fascinating structural and mechanistic diversity are potential inhibitors of bacterial pyruvate kinase, GTPase, FtsZ, efflux pump, DNA gyrase, and topoisomerase IV, revealing the potential of indole derivatives for fighting against various bacteria, even hard‐to‐treat pathogens including MRSA. [ 47,48 ] Accordingly, 1,2,4‐triazole–indole hybrids are potential prototypes for the discovery of novel anti‐MRSA candidates.…”

Section: 24‐triazole–indole Hybridsmentioning

confidence: 99%

1,2,4‐Triazole hybrids with potential antibacterial activity against methicillin‐resistant Staphylococcus aureus

2020

Archiv der Pharmazie

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Methicillin‐resistant Staphylococcus aureus (MRSA) has developed numerous mechanisms of virulence and strategies to evade the human immune system, and it can be transmitted between humans, animals, and the environment. Thus, MRSA is an important cause of morbidity and mortality in both hospitals and in the community, creating an urgent demand for the development of novel anti‐MRSA candidates. The 1,2,4‐triazole nucleus is a bioisostere of amide, ester, and carboxylic acid, and the 1,2,4‐triazole ring is found in many compounds with diverse biological effects. 1,2,4‐Triazole derivatives could exert their antibacterial activity through inhibition of efflux pumps, filamentous temperature‐sensitive protein Z, penicillin‐binding protein, DNA gyrase, and topoisomerase IV, and they play an important role in the discovery of novel antibacterial agents. Among them, 1,2,4‐triazole hybrids, which have the potential to exert dual/multiple mechanisms of action, possess a promising broad‐spectrum antibacterial activity against a panel of clinically important drug‐resistant pathogens including MRSA. This review outlines the recent developments of 1,2,4‐triazole hybrids with a potential anti‐MRSA activity, covering articles published between 2010 and 2020. The mechanisms of action, critical aspects of their design, and structure–activity relationships are also discussed.

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“…Indole (Figure 1) derivatives are ubiquitous in natural resources and they present a wide structural and mechanistic diversity. [9,10] Indole derivatives possess a variety of pharmacological properties, including anticancer, [11,12] antimalarial, [13,14] antiviral, [15,16] and antibacterial [17,18] activities, and play an intriguing role in the discovery of new drugs. The mechanistic study demonstrated that indole derivatives could exhibit the antibacterial activity through diverse mechanisms, including the inhibition of bacterial pyruvate kinase (PK), GTPase, filamentous temperature-sensitive protein Z (FtsZ), efflux pump, DNA gyrase, and topoisomerase IV; thus, these derivatives possess a potential activity against a panel of clinically important drug-sensitive and drug-resistant, and even multidrugresistant pathogens including MRSA.…”

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Recent advances in indole dimers and hybrids with antibacterial activity against methicillin‐resistant Staphylococcus aureus

Meng

Hou

Shang

et al. 2020

Archiv der Pharmazie

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Methicillin‐resistant Staphylococcus aureus (MRSA), one of the major and most dangerous pathogens in humans, is a causative agent of severe pandemic of mainly skin and soft tissue and occasionally fatal infections. Therefore, it is imperative to develop potent and novel anti‐MRSA agents. Indole derivatives could act against diverse enzymes and receptors in bacteria, occupying a salient place in the development of novel antibacterial agents. Dimerization and hybridization are common strategies to discover new drugs, and a number of indole dimers and hybrids possess potential antibacterial activity against a panel of clinically important pathogens including MRSA. Accordingly, indole dimers and hybrids are privileged scaffolds for the discovery of novel anti‐MRSA agents. This review outlines the recent development of indole dimers and hybrids with a potential activity against MRSA, covering articles published between 2010 and 2020. The structure–activity relationship and the mechanism of action are also discussed to facilitate further rational design of more effective candidates.

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Natural indole‐containing alkaloids and their antibacterial activities

Cited by 46 publications

References 99 publications

Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

1,2,4‐Triazole hybrids with potential antibacterial activity against methicillin‐resistant Staphylococcus aureus

Recent advances in indole dimers and hybrids with antibacterial activity against methicillin‐resistant Staphylococcus aureus

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