Gating capacitive field-effect sensors by the charge of nanoparticle/molecule hybrids

Poghossian, Arshak; Bäcker, Matthias; Mayer, Dirk; Schöning, Michael J.

doi:10.1039/c4nr05987e

Cited by 43 publications

(44 citation statements)

References 53 publications

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“…In addition, because EGOFETs are sensitive to capacitance changes (a typical surface effect), NPs should be extremely pertinent in EGOFETs. As an example of what could be done, Poghossian et al, not in an organic-based but in a silicon-based device, reported a gating capacitive field-effect sensor [108] for detection of charged molecules using gold NPs to increase the capacitive effect ( Figure 18). Bao's group also reported biodetection using a classical bottom-gate OFET decorated with gold nanoparticles, which were used to vary spacing between receptors [109].…”

Section: Use Of Nanoparticlesmentioning

confidence: 99%

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

2016

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Electrolyte-gated organic field-effect transistors have emerged in the field of biosensors over the last five years, due to their attractive simplicity and high sensitivity to interfacial changes, both on the gate/electrolyte and semiconductor/electrolyte interfaces, where a target-specific bioreceptor can be immobilized. This article reviews the recent literature concerning biosensing with such transistors, gives clues to understanding the basic principles under which electrolyte-gated organic field-effect transistors work, and details the transduction mechanisms that were investigated to convert a receptor/target association into a change in drain current.

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Section: Use Of Nanoparticlesmentioning

confidence: 99%

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

2016

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“…Indeed, the EIS devices are electrochemical analogues of electronic elements used in conventional electronic logic gates and computing systems. Previous research, not always related to the logic gates, has demonstrated the use of EIS devices for detection of pH changes and for the analysis of enzymatic reactions and charged macromolecules (DNA, proteins, polyelectrolytes) . Thus, the use of the EIS electronic devices is straightforward for transduction of various output signals generated by the enzyme logic systems.…”

Section: Electrochemical Analysis Of the Output Signals Generated Bymentioning

confidence: 99%

“…Previous research, not always relatedt ot he logic gates, has demonstrated the use of EIS devicesf or detection of pH changes [170] and fort he analysis of enzymatic reactions [171,172] and charged macromolecules (DNA, proteins, polyelectrolytes). [173][174][175] Thus, the use of the EIS electronic devicesi ss traightforward for transduction of various output signals generated by the enzymel ogic systems.…”

Section: Transduction Of Chemical Outputs Ignals Produced By the Enzymentioning

confidence: 99%

Enzyme‐Based Logic Gates and Networks with Output Signals Analyzed by Various Methods

Katz

2017

ChemPhysChem

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The paper overviews various methods that are used for the analysis of output signals generated by enzyme‐based logic systems. The considered methods include optical techniques (optical absorbance, fluorescence spectroscopy, surface plasmon resonance), electrochemical techniques (cyclic voltammetry, potentiometry, impedance spectroscopy, conductivity measurements, use of field effect transistor devices, pH measurements), and various mechanoelectronic methods (using atomic force microscope, quartz crystal microbalance). Although each of the methods is well known for various bioanalytical applications, their use in combination with the biomolecular logic systems is rather new and sometimes not trivial. Many of the discussed methods have been combined with the use of signal‐responsive materials to transduce and amplify biomolecular signals generated by the logic operations. Interfacing of biocomputing logic systems with electronics and “smart” signal‐responsive materials allows logic operations be extended to actuation functions; for example, stimulating molecular release and switchable features of bioelectronic devices, such as biofuel cells. The purpose of this review article is to emphasize the broad variability of the bioanalytical systems applied for signal transduction in biocomputing processes. All bioanalytical systems discussed in the article are exemplified with specific logic gates and multi‐gate networks realized with enzyme‐based biocatalytic cascades.

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“…Such systems can be understood as electrochemical analogues of electronic logic elements. In previous experiments, capacitive field-effect devices have been widely used for measuring the concentration of different ions and products of enzymatic reactions [23][24][25] as well as for the detection of various charged macromolecules (DNA, proteins, polyelectrolytes) and nanoobjects (e. g., gold nanoparticles, carbon nanotubes) [26][27][28][29][30][31]. Consequently, also EIS sensors can be favorably applied as a universal platform for developing various chemical and biomolecular logic gates.…”

Section: Enzyme Logic Gates Based On a Field-effect Eis Sensormentioning

confidence: 99%

“…For the OR logic-gate experiments, the multienzyme EIS sensor was exposed to buffer (pH 7.5), glucose (1 mM), ethyl butyrate (1 mM) or a mixture of glucose/ethyl butyrate solutions as biochemical inputs. The resulting EIS sensor signal, corresponding to the logic 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 output of the enzymatic reactions, was monitored by dynamic constant-capacitance measurements (ConCap [30]) using an impedance analyzer (Zahner Elektrik, Germany).…”

Section: Enzyme Logic Gates Based On a Field-effect Eis Sensormentioning

confidence: 99%

Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips

et al. 2017

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The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug‐release, and closed‐loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field‐effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field‐effect electrolyte‐insulator‐semiconductor sensor modified with a multi‐enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed‐loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.

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Gating capacitive field-effect sensors by the charge of nanoparticle/molecule hybrids

Cited by 43 publications

References 53 publications

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

Enzyme‐Based Logic Gates and Networks with Output Signals Analyzed by Various Methods

Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips

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