Gated Mesoporous Silica Nanoparticles Using a Double‐Role Circular Peptide for the Controlled and Target‐Preferential Release of Doxorubicin in CXCR4‐Expresing Lymphoma Cells

Abstract

B‐cell non‐Hodgkin's lymphoma (B‐NHL) is the most frequent malignant lymphoid neoplasm, which has a high degree of relapse and chemoresistance. Thus, strategies to improve currently used therapies are needed. In this context, a new CXCR4‐targeted delivery system is described using mesoporous silica nanoparticles (MSNs) that are loaded with doxorubicin and capped with a derivative of the T22 peptide (P). This design makes full use of the great affinity of the T22 peptide to CXCR4 receptor, which is overexpressed in lymphoma cells. The peptide is able to guide the gated nanoparticle to B‐NHL cells to facilitate MSNs uptake via the CXCR4 receptor. The endocyted P‐capped MSNs are also opened by endosomal proteolytic enzymes to allow intracellular doxorubicin delivery.

Nanocomposite Hydrogels as Platform for Cells Growth, Proliferation, and Chemotaxis

“…Herein, we report the preparation of a nanocomposite hydrogel composed of chemically cross‐linked biocompatible polymer chains, such as polyamidoamines and mesoporous silica nanoparticles (MSNs) covalently linked to the hydrogel. We studied the mechanical and elasticity properties and the biocompatibility using MSC and finally we investigated the efficiency of this hydrogel along with SDF‐1α, encapsulated in MSNs and released, in promoting MSC migration in vitro. Encouraged by the obtained results, we tested the effects of the nanocomposite with SDF‐1α in vivo, to evaluate the tissue response in the acute inflammatory window (3–7 d).…”

Mesoporous Silica‐Based Materials with Bactericidal Properties

“…Moreover, the pore‐blockers should respond to appropriate external or internal triggers to close or open the well‐defined pores, causing on‐demand intelligent cargo delivery . Various porekeepers including polymers (e.g., polymer poly(2‐vinylpyridine) (PVP), poly(N‐succinimidyl acrylate), poly(2‐dimethylaminoethyl methacrylate), poly(acrylic acid) brush), host–guest assemblies (e.g., Cyclodextrins, cucurbit,uril, pillararenes), inorganic nanomaterials (e.g., Au NPs, quantum dots, Ag NPs, cerium oxide NPs, manganese oxide NPs, and reduced graphene), and biomacromolecules (e.g., peptides, nucleic acids, saccharides, and proteins) have been employed under certain internal or external stimuli, such as pH, temperature, light, redox potential, ultrasound, small molecules, biomolecules, and or a combination of these stimuli, to achieve controllable DDSs based on mesoporous silica nanoparticles (MSNs) …”

Mesoporous silica materials for controlled delivery based on enzymes

“…Martínez-Máñez and co-workers prepared MSNs loaded with DOX and capped with a cyclic peptide to obtain a nanomaterial to target B-cell non-Hodking's lymphoma (B-NHL), the most frequent malignant lymphoid neoplasm. 40 MSNs were loaded with DOX and the external surface of nanoparticles was decorated with alkyne moieties using a propargylamine derivative. Finally, pores were capped with an azide-functionalised T22 peptide analogue (that recognises the CXCR4 receptor in B-NHL cells) using a "click" chemistry reaction.…”