‘Gate effect’ in molecularly imprinted polymers: the current state of understanding

Sharma, Piyush Sindhu; García‐Cruz, Álvaro; Cieplak, Maciej; Noworyta, Krzysztof; Kutner, Włodzimierz

doi:10.1016/j.coelec.2019.04.020

Cited by 74 publications

(66 citation statements)

References 53 publications

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“…Figure 4 shows a small semicircle at high frequencies and a straight line at low frequencies for bare GCE with R et = 255 Ω, which is characteristic of a fast electron transfer kinetics and a diffusion-limited step of electrochemical process. The high R et value of 11478 Ω obtained for MIP/DHP suggests a considerable increase in resistance to electronic transfer and can be attributed to the non-conductive properties of this type of material [48]. For MWCNTox/DHP it was observed R et = 1788 Ω higher than GCE, attributed to the DHP presence in film [49].…”

Section: Characterization Of the Mip/mwcnt/dhp Sensor By Eismentioning

confidence: 99%

Development of Electrochemical Platform Based on Molecularly Imprinted Poly(methacrylic acid) Grafted on Iniferter‐modified Carbon Nanotubes for 17β‐Estradiol Determination in Water Samples

et al. 2020

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This paper describes the development of a new electrochemical sensor for 17β‐estradiol (E2) determination based on glassy carbon electrode (GCE) modified with molecularly imprinted polymer grafted onto iniferter‐multiwall carbon nanotubes surface (MIP‐MWCNT) and dihexadecyl‐hydrogen‐phosphate (DHP). The electrochemical method was based on closed‐circuit preconcentration of E2 in 0.1 mol L−1 phosphate buffer (pH 7.0) during 500 s. Upon preconcentration, E2 was determined by differential pulse voltammetry (DPV) exhibiting a limit of detection of 0.01 μmol L−1. The sensor exhibited higher selectivity toward E2 and it was applied for E2 determination in natural water samples, with accuracy attested by HPLC‐DAD.

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Section: Characterization Of the Mip/mwcnt/dhp Sensor By Eismentioning

confidence: 99%

Development of Electrochemical Platform Based on Molecularly Imprinted Poly(methacrylic acid) Grafted on Iniferter‐modified Carbon Nanotubes for 17β‐Estradiol Determination in Water Samples

et al. 2020

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“…As a result, the intensity of the electrochemical signals was significantly shortened (curve b). After removing the template from the MIPs NPs matrix, the current response sharply increased, indicating that probe molecules diffused to the electrode surface through cavity regeneration (curve d), which invoked the so-called ‘gate effect’ [72] . At last, the MIPs NPs/MoS 2 @N-GQDs-IL/GCE after binding IgG (curve c) showed that the peak current decreased relative to curve d. This was called cavity occupation (sites of recognition) by IgG.…”

Section: Resultsmentioning

confidence: 99%

An advanced molecularly imprinted electrochemical sensor for the highly sensitive and selective detection and determination of Human IgG

Liang

Hou

Tang

et al. 2021

Bioelectrochemistry

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“…Recently, DET based biosensing methods gained much attention due to the unique advantages such as eliminating the leachable artificial mediators and operation in a potential window close to the redox potential of the biorecognition element ( Teymourian et al, 2020 ). Some of the surface imprinted or MIP based electrochemical sensors also works on the DET principle ( Bosserdt et al, 2013 ; Peng et al, 2016 ; Sharma et al, 2019 ). This sub-section presents an overview of different electrochemical approaches based on the DET in the detection of various viruses, such as HIV-1 ( Bhimji et al, 2013 ; Lee et al, 2013 ; Shin et al, 2019 ), HBV ( Asran et al, 2020 ), Zika ( Tancharoen et al, 2019 ), Influenza ( Fu et al, 2014 ) and Dengue virus ( Navakul et al, 2017 ).…”

Section: Electrochemical Diagnosticsmentioning

confidence: 99%

Electrochemical diagnostics of infectious viral diseases: Trends and challenges

Goud

Reddy

Khorshed

et al. 2021

Biosensors and Bioelectronics

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Infectious diseases caused by viruses can elevate up to undesired pandemic conditions affecting the global population and normal life function. These in turn impact the established world economy, create jobless situations, physical, mental, emotional stress, and challenge the human survival. Therefore, timely detection, treatment, isolation and prevention of spreading the pandemic infectious diseases not beyond the originated town is critical to avoid global impairment of life (e.g., Corona virus disease - 2019, COVID-19). The objective of this review article is to emphasize the recent advancements in the electrochemical diagnostics of twelve life-threatening viruses namely - COVID-19, Middle east respiratory syndrome (MERS), Severe acute respiratory syndrome (SARS), Influenza, Hepatitis, Human immunodeficiency virus (HIV), Human papilloma virus (HPV), Zika virus, Herpes simplex virus, Chikungunya, Dengue, and Rotavirus. This review describes the design, principle, underlying rationale, receptor, and mechanistic aspects of sensor systems reported for such viruses. Electrochemical sensor systems which comprised either antibody or aptamers or direct/mediated electron transfer in the recognition matrix were explicitly segregated into separate sub-sections for critical comparison. This review emphasizes the current challenges involved in translating laboratory research to real-world device applications, future prospects and commercialization aspects of electrochemical diagnostic devices for virus detection. The background and overall progress provided in this review are expected to be insightful to the researchers in sensor field and facilitate the design and fabrication of electrochemical sensors for life-threatening viruses with broader applicability to any desired pathogens.

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‘Gate effect’ in molecularly imprinted polymers: the current state of understanding

Cited by 74 publications

References 53 publications

Development of Electrochemical Platform Based on Molecularly Imprinted Poly(methacrylic acid) Grafted on Iniferter‐modified Carbon Nanotubes for 17β‐Estradiol Determination in Water Samples

Development of Electrochemical Platform Based on Molecularly Imprinted Poly(methacrylic acid) Grafted on Iniferter‐modified Carbon Nanotubes for 17β‐Estradiol Determination in Water Samples

An advanced molecularly imprinted electrochemical sensor for the highly sensitive and selective detection and determination of Human IgG

Electrochemical diagnostics of infectious viral diseases: Trends and challenges

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