Gastroschisis annual incidence, mortality, and trends in extreme Southern Brazil

Egger, Paulo Acácio; Souza, Makcileni Paranho de; Riedo, Cristiane de Oliveira; Dutra, Amanda de Carvalho; Silva, Mariana Teixeira da; Pelloso, Sandra Marisa; Carvalho, Maria Dalva de Barros

doi:10.1016/j.jped.2021.04.007

Cited by 9 publications

(9 citation statements)

References 25 publications

(44 reference statements)

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“…Analysis by sex (p=0.10) showed no statistically significant difference, as previously reported. [24,26,29] Although no difference was found between GS and non-GS babies regarding race (p=0.96), international studies reported differences in prevalence concerning race/color. [27,30] Limitations: Because this study was based on secondary data, the ascertainment of information was conditional on the completeness and accuracy of the available records and the level of clinical detail obtained was limited.…”

Section: Esophageal Atresia (Ea)mentioning

confidence: 84%

“…In South Brazil, women pregnant with babies with GS had a significantly smaller number of prenatal consultations, which is worrisome given the complexity of this malformation and the high risk of preterm delivery. [27,30] Egger et al [29] found a 5.7 relative risk of premature birth for GS. Indeed, 53.3% of babies with this malformation in South Brazil (613/1150, Table 2) were born <37 weeks of gestation, and there was an association between preterm delivery and GS.…”

Section: Esophageal Atresia (Ea)mentioning

confidence: 99%

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Epidemiology of congenital diaphragmatic hernia, esophageal atresia, and gastroschisis in South Brazil

et al. 2023

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Background: Birth defects remain a major contributor to infant mortality and lifelong disabilities. The epidemiology of congenital abnormalities varies around the world and little information is available from Latin America. Methods: This is an epidemiological, descriptive, cross-sectional study with data from the Department of Informatics of the Unified Health System (DATASUS) on Congenital diaphragmatic hernia (CDH), esophageal atresia (EA) and gastroschisis (GS) in South Brazil from 2009 to 2019. Results: The incidence of CDH is 0.93 cases, while EA is 0.47 and GS is 2.87, all per 10,000 live births. There is an association between all the malformations and premature birth, cesarean delivery, low birth weight, and low Apgar scores. Both EA and GS are associated with maternal age, EA with older, and GS with younger mothers. While EA is associated with multiple pregnancies, GS is associated with fewer years of maternal formal education, single parenting, and a lower number of prenatal consultations. CDH is associated with the male sex and black ethnicity. Conclusion: This large population-based study estimates the prevalence and demographic factors associated with CDH, EA, and GS, and extends the limited descriptive epidemiologic information available.

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Section: Esophageal Atresia (Ea)mentioning

confidence: 84%

Section: Esophageal Atresia (Ea)mentioning

confidence: 99%

Epidemiology of congenital diaphragmatic hernia, esophageal atresia, and gastroschisis in South Brazil

et al. 2023

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“…This database has been validated and previously used for public health and perinatal epidemiological research and surveillance. [24][25][26]…”

Section: Data Sourcesmentioning

confidence: 99%

Epidemiological characteristics of live births with esophageal atresia in Sao Paulo State, Brazil, from 2005 to 2018

Silvestri

Oliveira

Chiedde

et al. 2022

World Jnl Ped Surgery

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BackgroundThe estimated prevalence of esophageal atresia (EA) is 1 in 2500–4500 live births (LBs). Researchers have already identified risk factors, but the mechanisms are still unknown. The aim of this study is to identify EA prevalence trends and its risk factors in the São Paulo State (SPS) population database.MethodsWe conducted a population-based study using all EA cases identified by the Live Births Information System across 14 years (2005–2018) to estimate EA prevalence trends in recent years, stratified by maternal age and SPS geographical clusters. We calculated the prevalence trends, regression coefficient (β), annual percent change (APC), and 95% confidence interval (CI).ResultsWe found 820 EA cases among 8,536,101 LBs with a prevalence of 1.0/10,000 LBs in SPS, Brazil. There was no significant difference in distribution by sex. Among all the cases, the majority (65%) were Caucasian; 51.8% were born at term; 43% had weight of ≥2500 g; 95.4% were singleton; and 73.4% of births were by cesarean section. From 2005 to 2018, there was an increasing trend of EA prevalence (APC=6.5%) with the highest APC of 12.2%. The highest EA prevalence rate (1.7/10,000 LB) was found in the group with maternal age of ≥35 years. No significant seasonal variation was found based on the conception month (p=0.061).ConclusionsEA had an increasing prevalence trend in SPS, Brazil, in recent years, with the highest prevalence rate in the group with maternal age of ≥35 years. No seasonality was observed. This population-based study is the first to summarize the current epidemiology of EA in SPS LB.

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“…European data from 1995 to 2012 showed a prevalence of gastroschisis of 1.97 per 10,000 births, of which 4% were stillbirths, and 11% pregnancy terminations (Given et al, 2017). In Brazil, state‐level data showed an increase in prevalence during the last decades (Calderon, de Sousa Santos, de Abreu, & Raimundo, 2019; Egger et al, 2022). Still, as observed in other low and middle‐income countries, there is a lack of evidence about the prevalence of gastroschisis at the national level.…”

Section: Introductionmentioning

confidence: 99%

Trends in prevalence of gastroschisis in Brazil from 2007 to 2020: A national population‐based cross‐sectional study

Regadas

Escosteguy

Fonseca

et al. 2023

Birth Defects Research

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Background: Gastroschisis is a congenital abnormality of the abdominal wall which worldwide prevalence is increasing with time. Up to now, young maternal age is the main factor associated with gastroschisis. Brazil has a great proportion of adolescent mothers. Objectives: To estimate prevalence of gastroschisis in Brazil, explore the effect of very young maternal age, and analyze regional distribution and time trends.Methods: Cross-sectional population-based study using data from official national information systems from 2007 to 2020, covering 9,831 gastroschisis cases. Low maternal age was assessed as risk factor through odds ratio. Prevalence time trends by maternal age and geographic area were analyzed using joinpoint regression. Results: Overall prevalence of gastroschisis in Brazil was 2.47 per 10,000 births. From first to last biennium, there was a 23% relative increase. Last biennium prevalence was higher in the Central-west region and lower in the Northeast.Compared to mothers of 20-34 years old (YO), the odds-ratio for prevalence and 95% confidence intervals for gastroschisis were, as follows: (a) 10-14 YO-4.9 (4.3,5.5); (b) 15-19 3.8); and (c) 35-49 YO-0.3 (95% CI 0.3, 0.4). Conclusions: Prevalence of gastroschisis in Brazil relatively increased 23% from 2007 to 2020. This happened in all maternal age groups. Differences between regions may be associated to data quality. Young mothers had a higher prevalence of gastroschisis and still higher for those under 15 YO. Mother age over 34 YO was a protective factor.

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Gastroschisis annual incidence, mortality, and trends in extreme Southern Brazil

Cited by 9 publications

References 25 publications

Epidemiology of congenital diaphragmatic hernia, esophageal atresia, and gastroschisis in South Brazil

Epidemiology of congenital diaphragmatic hernia, esophageal atresia, and gastroschisis in South Brazil

Epidemiological characteristics of live births with esophageal atresia in Sao Paulo State, Brazil, from 2005 to 2018

Trends in prevalence of gastroschisis in Brazil from 2007 to 2020: A national population‐based cross‐sectional study

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