Gastroretentive Delivery Systems: A Mini Review

Abstract

Various attempts have been made to develop gastroretentive delivery systems. For example, floating, swelling, mucoadhesive, and high-density systems have been developed to increase gastric retention time of the dosage forms. It is known that differences in gastric physiology, such as, gastric pH, and motility exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. Nevertheless, some floating devices have shown promising results. In this paper, the gastric physiology and the reported intragastric delivery systems have briefly been presented.

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

“…Since L-DOPA is mostly absorbed in the first part of the small intestine (duodenum), gastroretentive delivery systems have been developed with the aim of prolonging the release of the drug in the area of maximal absorbance. Studies have not yet been performed in humans [12]. Odak et al used highly soluble hydroxypropylated -cyclodextrin to form stable complexes with L-DOPA.…”

Goodness-of-Fit Model-Dependent Approach for Release Kinetics of Levofloxacin Hemihydrates Floating Tablet

“…Extended resident time of the antimicrobial agent is desirable for more effective eradication of H. pylori (1,5). To extend the residence period, several approaches have been developed such as floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices (6)(7)(8).…”

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“…Bio/muco-adhesive systems [28][29][30] Bio/muco-adhesive systems are those which bind to the gastric epithelial surface or mucin and serve as a potential means of extending the GRT of drug delivery system (DDS) in the stomach.…”