Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid–induced gastric ulcer in rats

Zeren, Sezgin; Bayhan, Zülfü; Koçak, Fatma Emel; Koçak, Cengiz; Akçılar, Raziye; Bayat, Zeynep; Şimşek, Hasan; Düzgün, Şükrü Aydın

doi:10.1016/j.jss.2016.03.027

Cited by 30 publications

(25 citation statements)

References 53 publications

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“…The participation of the antioxidant mechanism has an important role in the ability to strengthen defensive factors. Among the monoterpenes, we highlight the gastroprotective effect of thymoquinone that decreases the oxidative damage of gastric mucosa by reducing lipid peroxidation, TOS (total oxidant status), and OSI (oxidative stress index) and increasing TAS (total antioxidant status) and TT (total thiol levels) [62].…”

Section: Mechanisms Of Action Of the Peptic Ulcersmentioning

confidence: 98%

“…Monoterpenes have demonstrated substantial gastroprotective action against NSAIDs in experimental models (in vivo). These include thymol [70], ascaridole [50], citral [45], eucalyptol or 1,8 cineole [51], epoxy-carvone [52], menthol [56,57], α-terpineol [61], thymoquinone [62], carvacrol [63], limonene [43], and β-myrcene [67]. Limonene, for example, was able to reduce up to 99% of gastric ulcer formation induced by indomethacin [43] (Table 2).…”

Section: Nsaidsmentioning

confidence: 99%

“…This stimulus is responsible for increasing the protective factors and maintaining gastric mucosal integrity. However, monoterpenes such as thymoquinone [62] present effective gastroprotective effects against NSAIDs acting in another way by reducing oxidative stress and increasing antioxidant defense mechanisms. An additional therapeutic purpose for monoterpenes is to improve therapeutic efficacy of NSAIDs (such as ibuprofen and acetylsalicylic acid) and retard gastrointestinal side-effects by use of prodrugs and promoieties like menthol, thymol, and eugenol that aim to have a synergistic effect as these are natural analgesics with traditional medicinal values [76].…”

Section: Nsaidsmentioning

confidence: 99%

“…GSH is found in high concentrations in the gastric mucosa acting directly as a potent antioxidant and indirectly as a substrate for antioxidant enzymes [91]. The monoterpenes menthol, thymoquinone, geraniol, limonene, thymol, and β-myrcene increase activities of antioxidant enzymes GSH, SOD, and GPx [52,53,56,[60][61][62][63][64].…”

Section: Mechanisms Of Action Of the Peptic Ulcersmentioning

confidence: 99%

“…Therefore, cytokines such as TNF-α, IL-6, and IL-10 are important factors in the severity of gastric ulcers [100]. The monoterpene limonene displayed anti-inflammatory activity by decreasing TNF-α, IL-6, and IL-1β and increasing the level of IL-10 [44,62,63].…”

Section: Mechanisms Of Action Of the Peptic Ulcersmentioning

confidence: 99%

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Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

et al. 2020

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Peptic ulcer disease (PUD) is a multifactorial and complex disease caused by an imbalance of protective and aggressive factors (endogenous and exogenous). Despite advances in recent years, it is still responsible for substantial mortality and triggering clinical problems. Over the last decades, the understanding of PUD has changed a lot with the discovery of Helicobacter pylori infection. However, this disease continues to be a challenge due to side-effects, incidence of relapse from use of various anti-ulcer medicines, and the rapid appearance of antimicrobial resistance with current H. pylori therapies. Consequently, there is the need to identify more effective and safe anti-ulcer agents. The search for new therapies with natural products is a viable alternative and has been encouraged. The literature reports the importance of monoterpenes based on the extensive pharmacological action of this class, including wound healing and anti-ulcerogenic agents. In the present study, 20 monoterpenes with anti-ulcerogenic properties were evaluated by assessing recent in vitro and in vivo studies. Here, we review the anti-ulcer effects of monoterpenes against ulcerogenic factors such as ethanol, nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori, highlighting challenges in the field.Biomolecules 2020, 10, 265 2 of 18 PUD results from an imbalance in mucosal defensive factors, such as mucus secretion, bicarbonate efflux, endogenous antioxidant, cell regeneration, continuous synthesis and release of prostaglandin E 2 (PGE 2 ), nitric oxide (NO), and sulfhydryl compounds (SH); and aggressive agents such as smoking, alcohol consumption, dietary factors, stress, prolonged and excessive intake of nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori (H. pylori) infection, among others [6][7][8][9]. For a long time, it was believed that the main factor implicated in the development and progression of peptic ulceration was an hypersecretory acidic environment and together with dietary factors and/or stress was thought to cause most of PUD. But the discovery of H. pylori infection and the widespread use of NSAIDs in the second half of the 20 th century changed this perception. In recent years, peptic ulcer has been found to have multiple causes-H. pylori infection, NSAIDs, smoking, alcohol consumption, stress, lifestyle, and genetic predispositions are determined as major risk factors for the development of PUD [2]. PathophysiologyUnder normal conditions, gastric and duodenal mucosa integrity is maintained by the mucus-bicarbonate barrier, the neutral pH, and continuous epithelial cell renewal [10,11]. PGE 2 stimulates cell proliferation, mucus, and bicarbonate production, promoting a crucial function in mucosa preservation. Another vital factor in gastric homeostasis is adequate blood flow. The NO and PGs are responsible for the maintenance of proper perfusion to the gastric mucosa, assuring the delivery of oxygen and nutrients, as well as removing toxic metabolites, preventing damages to the ti...

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Section: Mechanisms Of Action Of the Peptic Ulcersmentioning

confidence: 98%

Section: Nsaidsmentioning

confidence: 99%

Section: Nsaidsmentioning

confidence: 99%

Section: Mechanisms Of Action Of the Peptic Ulcersmentioning

confidence: 99%

Section: Mechanisms Of Action Of the Peptic Ulcersmentioning

confidence: 99%

See 3 more Smart Citations

Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

et al. 2020

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Economic assessment of a small‐scale plant for production of sulforaphane‐rich broccoli flour in Chile

Quintero

Román

Salazar

et al. 2020

Biofuels Bioprod Bioref

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Broccoli offers several health benefits due to its high content of bioactive compounds, especially sulforaphane -a promising anticancer compound. In Chile, the broccoli crop is expanding rapidly, creating opportunities to industrialize this vegetable and exploit its functional properties. Various processes have been studied with the aim of maximizing the sulforaphane content in processed broccoli using different dehydration methods. These have shown large differences in terms of recovery and cost. This work shows an economic feasibility study of a small-scale plant for the production of sulforaphane-rich broccoli flour considering three drying alternatives: tray drying (TD), pulsed fluidized-bed drying, and freeze-drying (FD). Freeze drying resulted in the highest sulforaphane content in the broccoli flour; however, this process entails the highest production cost. Tray drying showed the lowest production cost and a comparatively high sulforaphane content in the final product. Pulsed fluidized bed drying (PFBD) resulted in the highest sulforaphane loss. Although the three drying technologies resulted in positive net present values (NPV), the internal rate of return (IRR) was the lowest for freeze drying as a result of the high investment -over 20% higher than the investment required by the other alternatives. The NPV was practically independent of the drying technology when the sulforaphane content was considered in the estimation of the selling price.

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Therapeutic perspective of thymoquinone: A mechanistic treatise

Butt¹,

Imran

et al. 2021

Food Science & Nutrition

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The higher utilization of fruits and vegetables is well known to cure human maladies due to the presence of bioactive components. Among these compounds, thymoquinone, a monoterpene and significant constituent in the essential oil of Nigella sativa L., has attained attention by the researchers due to their pharmacologies perspectives such as prevention from cancer, antidiabetic and antiobesity, prevention from oxidative stress and cardioprotective disorder. Thymoquinone has been found to work as anticancer agent against different human and animal cancer stages including propagation, migration, and invasion. Thymoquinone as phytochemical also downregulated the Rac1 expression, mediated the miR‐34a upregulation, and increased the levels of miR‐34a through p53, as well as also regulated the pro‐ and antiapoptotic genes and decreased the phosphorylation of NF‐κB and IKKα/β. In addition, thymoquinone also lowered the metastasis and ERK1/2 and PI3K activities. The present review article has been piled by adapting narrative review method and highlights the diverse aspects of thymoquinone such as hepatoprotective, anti‐inflammatory, and antiaging through various pathways, and further utilization of this compound in diet has been proven effective against different types of cancers.

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Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid–induced gastric ulcer in rats

Cited by 30 publications

References 53 publications

Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

Economic assessment of a small‐scale plant for production of sulforaphane‐rich broccoli flour in Chile

Therapeutic perspective of thymoquinone: A mechanistic treatise

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