Gastroprotective effects of methanol extract of <i>Eremomastax speciosa</i> leaf harvested in Southern part of Nigeria in rat

Onoja, Samuel O.; Chinagorom, Osborn; Ikpa, Chinyere Benardette Chinaka; Madubuike, Kelechi G.; Ezeigbo, II; Ijioma, Solomon Nnah; Anaga, Aruh O.; Ezeja, Maxwell I.

doi:10.2478/ebtj-2018-0050

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…An ulcer is one of the frequent reasons for hospital visits, and its incidence is rising globally [1]. Peptic ulcers are a non-fatal condition that are primarily characterized by recurrent sensations of epigastric pain, which are frequently eased by food or alkali, in addition to giving patients great discomfort, upsetting their daily schedules, and also inflicting mental anguish [2].…”

Section: Introductionmentioning

confidence: 99%

In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis

Ms. Sowmya B.A,

Dr. Satish Pavuluri

2023

Trop. j. pharm. life sci.

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For the treatment and prevention of illnesses and disorders, medicinal plants are recognized to contain conventional therapeutic substances. This study examined the potential of ethanol extracts of Saponaria officinalis to block H+/K+ ATPase and neutralize acids in order to determine whether they may be utilized to cure ulcers. In traditional medicine, the Saponaria officinalis is used to treat gastrointestinal disorders and inflammation. The acidity of the extract at a 1500 mg/ml concentration was much lower than that of conventional aluminium hydroxide + magnesium hydroxide (500mg), falling to 5.33 from 12.7. The ethanol extract of Saponaria officinalis at a concentration of 100μg, showed maximum percentage of inhibition of 67.17±1.96% as compared to omeprazole 71.47±0.52%, demonstrated the highest percentage of inhibition of the H+/K+ - ATPase. The results of this study suggest that Saponaria officinalis ethanol extract contains substances that can block enzymes and neutralize acids, making it a potential alternative treatment for digestive issues.

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Section: Introductionmentioning

confidence: 99%

In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis

Ms. Sowmya B.A,

Dr. Satish Pavuluri

2023

Trop. j. pharm. life sci.

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Psidium guajava leaf extract improves gastrointestinal functions in rats and rabbits: an implication for ulcer and diarrhoea management

et al. 2021

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Malva parviflora Leaves and Fruits Mucilage as Natural Sources of Anti-Inflammatory, Antitussive and Gastro-Protective Agents: A Comparative Study Using Rat Models and Gas Chromatography

et al. 2022

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Malva parviflora L., Little mallow, has been traditionally used as an alternative food source. It acts as a medicinal herb containing a potential source of mucilage thus herein; we aimed to assess the toxicity, anti-inflammatory, antitussive and gastro-protective actions of M. parviflora mucilage extracted from its leaves (MLM) and fruit (MFM). Toxicity studies were investigated by in vitro hemolytic assay whereas acute anti-inflammatory and antitussive activities were assessed by carrageenan-induced paw edema and sulphur dioxide induced cough model in rats, respectively. Gastro-protective effects were studied using ethanol induced acute and chronic gastric ulcer rat models. Their metabolic profiles were determined using gas chromatography. The results revealed that MLM and MFM were non-toxic towards human erythrocytes and their lethal doses were found to be greater than 5 g/kg. Pretreatment with MLM (500 mg/kg) and MFM (500 mg/kg) significantly reduced the carrageenan-induced paw thickness (p < 0.001). Maximum edema inhibition (%) was observed at 4 h in diclofenac sodium (39.31%) followed by MLM (27.35%) and MFM (15.68%). Animals pretreated with MLM (500 mg/kg) significantly lower the cough frequency in SO2 gas induced cough models in contrast to control. Moreover, MLM at doses of 250 and 500 mg/kg reduced the ethanol induced gastric mucosal injuries in acute gastric ulcer models presenting ulcer inhibition of 23.04 and 38.74%, respectively. The chronic gastric ulcer model MFM (500 mg/kg) demonstrated a remarkable gastro-protective effect showing 63.52% ulcer inhibition and results were closely related to standard drug sucralfate. In both models, MLM and MFM decreased gastric juice volume and total acidity in addition to an increased gastric juice pH and gastric mucous content justifying an anti-secretary role of this mucilage that was further confirmed by histopathological examination. Meanwhile, GC analyses of the mucilage revealed their richness with natural as well as acidic monosaccharides. It is concluded that MLM and MFM can be used therapeutically for the management of inflammation, cough and gastric ulcer.

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Gastroprotective effects of methanol extract of Eremomastax speciosa leaf harvested in Southern part of Nigeria in rat

Cited by 3 publications

References 32 publications

In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis

In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis

Psidium guajava leaf extract improves gastrointestinal functions in rats and rabbits: an implication for ulcer and diarrhoea management

Malva parviflora Leaves and Fruits Mucilage as Natural Sources of Anti-Inflammatory, Antitussive and Gastro-Protective Agents: A Comparative Study Using Rat Models and Gas Chromatography

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