<i>Psidium guajava</i> leaf extract improves gastrointestinal functions in rats and rabbits: an implication for ulcer and diarrhoea management

Ibeh, Lilian Ngozi; Ijioma, Solomon Nnah; Emmanuel, Okezie; Timothy, Christopher O; Ugbogu, Eziuche Amadike

doi:10.1080/1354750x.2021.1992651

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…This genus is known to possess various biological activities, such as analgesic [20][21][22], anti-inflammatory [22][23][24], gastroprotective [25,26], and antimicrobial effects [27][28][29], among others. Among these species, we have Psidium glaziovianum, commonly known as araçápitanga, which grows in the northeastern and southeastern regions of Brazil; this species is known for its edible fruits, which are similar to guavas, and it is also used in traditional medicine for various purposes [30].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Costa,

Alves,

Fonseca

et al. 2024

DDC

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Rheumatoid arthritis (RA) is a chronic and debilitating condition that affects a significant number of individuals worldwide. Unfortunately, the currently available therapeutic approaches often yield unsatisfactory results and may be accompanied by harmful side effects. A medicinal plant called Psidium glaziovianum Kiaersk has potential benefits in the treatment of this condition due to its anti-inflammatory and analgesic properties. In this study, our objective was to investigate the potential therapeutic effects of P. glaziovianum essential oil (PgEO) in alleviating arthritis symptoms in mice induced by Complete Freund’s Adjuvant (CFA). The effect of P. glaziovianum essential oil was evaluated in mice with Complete Freund’s Adjuvant (CFA)-induced arthritis. Edema sizes, macroscopic and radiographic images, cytokine levels, and oxidative stress were evaluated. Administration of PgEO at dosages of 50 and 100 mg/kg effectively prevented CFA-induced osteoarticular changes in arthritic mice, resulting in a significant reduction in joint damage. Additionally, the PgEO treatment exhibited the ability to minimize edema, a common symptom associated with arthritis. Furthermore, PgEO can modulate the levels of pro-inflammatory cytokines and oxidative stress, both of which play crucial roles in the progression of the disease. In conclusion, our study suggests that PgEO holds great potential as a natural therapeutic agent for rheumatoid arthritis.

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Section: Introductionmentioning

confidence: 99%

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Costa,

Alves,

Fonseca

et al. 2024

DDC

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A review of ethnobotanical studies reveals over 500 medicinal plants in Mindanao, Philippines

Meñiza,

Pasco,

Alimbon

2024

Plant Diversity

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Ethnobotany, phytochemistry, and biological activities of Psidium guajava in the treatment of diarrhea: a review

Liu,

Jullian,

Chassagne

2024

Front. Pharmacol.

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Psidium guajava: is a tropical tree that is widely used in traditional medicine, especially for treating diarrhea. While P. guajava has been the subject of numerous reviews, none have specifically examined its ethnobotany, pharmacology, and phytochemistry in relation to its antidiarrheal activity. This review aims to summarize the evidence of effectiveness and safety of P. guajava in the treatment of diarrhea. Literature searches were conducted through Web of Science, PubMed, and ScienceDirect by using keywords “Psidium guajava” and “diarrhea” in October 2022. A total of 189 studies were included in this review. P. guajava is widely used in traditional medicine in 44 countries. Decoction and oral were the most represented method of preparation and administration, respectively, while leaves represented the most frequently cited part of the plant. Around 27 antidiarrheal or antibacterial compounds have been isolated and identified, including benzophenone glycosides, terpenes, polysaccharides, phenols, and flavonoids. This article presents ethnobotanical and pharmacological evidence for the efficacy of P. guajava leaves in the treatment of diarrhea and provides reference information for further investigation of this plant. However, despite the large number of publications on the topic, there are still some questions to answer: are quercetin and its glycosides the only ones to act as antidiarrheal agents? What is the mechanism of action of P. guajava antidiarrheal compounds? are the use of guava leaves safe in all types of populations including children, and at what dosage? To answer these questions, more complete phytochemical studies and systematic clinical trials are needed.

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Psidium guajava leaf extract improves gastrointestinal functions in rats and rabbits: an implication for ulcer and diarrhoea management

Cited by 3 publications

References 24 publications

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

A review of ethnobotanical studies reveals over 500 medicinal plants in Mindanao, Philippines

Ethnobotany, phytochemistry, and biological activities of Psidium guajava in the treatment of diarrhea: a review

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