Gastroprotective Effects of DAS-77 (a Phytomedicine) in Ulcer Models in Rats

Akindele, Abidemi J.; Aigbe, Flora Ruth; Olowe, Johnson A; Oduntan, Babajide O; Adeyemi, Olufunmilayo O.

doi:10.4314/tjpr.v11i5.12

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…Antiulcer potential of ethanol and petroleum ether extracts prepared from mango leaves has also been reported by Neelima et al 2012 [ 279 ]. Akindele et al 2012 [ 280 ] who assessed gastroprotective effects of a drug formulation (DAS-77) which comprises M. indica bark and papaya roots showed a significant reduction of gastric ulcers after feeding with DAS-77 in rat models. Antiulcer activity of an ethanolic extract of mango kernels and in combination with vitamin C, ZnSO 4, and menadione in pylorus ligation and ethanol-induced ulcers in rat models was evaluated by Nethravathi K et al 2015 [ 281 ].…”

Section: Pharmacological Properties Of M Indicamentioning

confidence: 99%

A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)

Ediriweera

Tennekoon

Samarakoon

2017

Evidence-Based Complementary and Alternative Medicine

153

106

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Mangifera indica (family Anacardiaceae), commonly known as mango, is a pharmacologically, ethnomedically, and phytochemically diverse plant. Various parts of M. indica tree have been used in traditional medicine for the treatment of different ailments, and a number of bioactive phytochemical constituents of M. indica have been reported, namely, polyphenols, terpenes, sterols, carotenoids, vitamins, and amino acids, and so forth. Several studies have proven the pharmacological potential of different parts of mango trees such as leaves, bark, fruit peel and flesh, roots, and flowers as anticancer, anti-inflammatory, antidiabetic, antioxidant, antibacterial, antifungal, anthelmintic, gastroprotective, hepatoprotective, immunomodulatory, antiplasmodial, and antihyperlipemic. In the present review, a comprehensive study on ethnopharmacological applications, pharmacological activities, and bioactive compounds of M. indica has been described.

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Section: Pharmacological Properties Of M Indicamentioning

confidence: 99%

A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)

Ediriweera

Tennekoon

Samarakoon

2017

Evidence-Based Complementary and Alternative Medicine

153

106

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“…The levels of superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GP), catalase (CAT), malondialdehyde (MDA) and nitrite were determined using a commercially available ELISA kit (Cayman, USA) [30].…”

Section: Methodsmentioning

confidence: 99%

Study of the mechanism of anti-ulcer effects of virgin coconut oil on gastric ulcer-induced rat model

Meng¹,

Chen²,

Zhao³

et al. 2019

aoms

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IntroductionThis study aims to evaluate the gastro-protective effects of virgin coconut oil (VCO) on different ulcer models as compared to the standard drug (omeprazole).Material and methodsThree groups of rats (6 rats per group for each ulcer model) were pre-treated with distilled water for the negative control group, 30 mg/kg of omeprazole for the positive control group and VCO (2 ml per rat) for the treatment group. Animals were pre-treated for 7 days and ulcers were induced with cold restraint stress, piroxicam, ethanol and pylorus ligation. On day eight, animals were sacrificed and ulcer scores were determined based on macroscopic evaluation. The gastric volume, pH, total acidity and mucus content were measured in the pylorus-ligated model. The levels of antioxidants were determined from the gastric tissue homogenates.ResultsVirgin coconut oil significantly (p < 0.001) inhibited the ulceration caused by different inducers. The percentage of inhibition for the VCO-treated group was 78.3%, 84.7%, 72.7% and 73.1%, while for the omeprazole-treated group it was 60.8%, 61.5%, 59% and 53.8% in cold restraint stress, ethanol, piroxicam and pylorus-ligated ulcer models, respectively. Virgin coconut oil significantly (p < 0.001) inhibited gastric juice volume and total acidity for VCO and omeprazole treated groups as compared to the non-treated negative control group. Moreover, VCO and omeprazole caused a significant (p < 0.001) increase of gastric mucus content and pH. Virgin coconut oil also proved to have significantly increased glutathione (GSH) and nitrite levels, whereas the levels of SOD, GP, MDA and CAT were significantly (p < 0.001) reduced by VCO relative to the control group. Virgin coconut oil also significantly (p < 0.001) increased the level of prostaglandin in rat tissue homogenate, similar to the omeprazole treated group.ConclusionsVirgin coconut oil shows a possible association with antioxidant properties to control the regulation of prostaglandin synthesis and protect against reactive oxygen species damage.

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“…The experiment was done as described by Akindele et al (2012), with slight modification. Fasted male rats were distributed into five groups consisting of seven animals each.…”

Section: Ethanol-induced Gastric Ulcer Modelmentioning

confidence: 99%

Antinociceptive and antiulcer activities of Pycnanthus angolensis

Sofidiya

Awolesi

2015

Revista Brasileira de Farmacognosia

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a b s t r a c tPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.

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Gastroprotective Effects of DAS-77 (a Phytomedicine) in Ulcer Models in Rats

Cited by 4 publications

References 19 publications

A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)

A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)

Study of the mechanism of anti-ulcer effects of virgin coconut oil on gastric ulcer-induced rat model

Antinociceptive and antiulcer activities of Pycnanthus angolensis

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