Gastroprotective effects and antimicrobial activity of Lithraea molleoides and isolated compounds against Helicobacter pylori

Orally administrated chitosan microspheres bind Helicobacter pylori and decrease gastric infection in mice

“…Focus has been given to understanding bacterial infection mechanisms and interaction with the host [19,20], identifying bacterial specific molecules that may represent potential targets, such as bacterial virulence factors, urease, flagella or surface adhesins [21][22][23]. The combination of these targets with improved encapsulation systems for local delivery of antibiotics (using micro-or nano-systems) [24][25][26][27][28][29][30][31][32][33], usage of compounds from natural sources [34][35][36][37][38][39][40][41] or vaccination [42][43][44][45] has allowed the development of more precise and efficient systems aiming H. pylori eradication.…”

Inhibition of Helicobacter pylori and Its Associated Urease by Two Regional Plants of San Luis Argentina

“…(Gutkind et al, 1981). On the other hand, L. molleoides possess phenolic acids, mannitol, flavonoids as bioactive compounds for which we demonstrated activity against sensible and resistant H. pylori strains (Garro et al, 2015). Additionally, we demonstrated that L. molleoides extract confers gastroprotective properties against gastric ulcers induced by different necrotizing agents in Wistar rats (Garro et al, 2015).…”

“…For its medicinal properties is used for the treatment of respiratory and digestive diseases among others. It is also, an ingredient of some foods such as "arrope" and "aloja" (Garro et al, 2015).…”

“…Two fold dilutions of both extracts were performed to obtain the following final concentrations: from 500 to 4 μg/mL and from 125 to 0.08 μg/mL for Cla, Amx and Mtz. Broth microdilution methods were carried out in 96-well microtitre plates as previously described (Garro et al, 2015). Minimal inhibitory concentration (MIC) was measured by determining the smallest amount of extract or antibiotic needed to inhibit the visible growth of the microorganism.…”

New 5-Alkenyl Resorcinols from <i>Lithraea molleoides</i> (Vell). Eng.

“…Infusions, decoctions or tinctures from the aerial parts (leaves, buds, and young stems) are used by rural people of these countries for its antiarthritic, hemostatic, diuretic, and tonic properties [6] as well as used for the treatment of respiratory diseases [7] and digestive inflammations illnesses [8]. Previous investigations on different extracts of L. molleoides have reported antiviral [9], antimicrobial [10], anti-inflammatory [11], anti-ulcerogenic [12], antinociceptive [13], and antibacterial [14] activities.…”