New 5-Alkenyl Resorcinols from <i>Lithraea molleoides</i> (Vell). Eng.

Abstract

Lithraea molleoides (Anacardiaceae) is a tree that grows in South America including Southern Brazil, Southern, and Eastern Bolivia, Southern Paraguay, Northern, and Central Argentina. Infusions, decoctions, or tinctures from its aerial parts (leaves, buds, and young stems) are employed in ethnomedicine mainly against respiratory, and digestive inflammations and illnesses. Antibacterial, antiviral, antioxidant, anti-inflammatory, and antinociceptive activities, among others, have been reported for L. molleoides. Many of its biological activities have been associated with the reported presence of 5-alkenyl resorcinols. Alkyl/alkenyl catechols and alkyl/alkenyl resorcinols are very common in members of the Anacardiaceae family and several activities have been attributed to them. This work describes the isolation and the structural elucidation of three new 5-alkenyl resorcinols isolated from Lithraea molleoides reported in nature for the first time.

A highly complex stingless bee propolis: Composition and influence of the period of collection

“…Regarding alkyl and alkenyl resorcinols (e.g., 72 and 82), they are characteristic constituents of Anacardiaceae, 97,98 as also are cycloartane-type triterpenes (e.g., 45, 64, and 80; Figure 1h) and xanthones (e.g., 7 and 8; Figure 1f). 99 The three classes of metabolites have been detected in chloroform extracts of propolis of the Indonesian meliponines Heterotrigona itama and Tetragonisca laeviceps and of mango fruits (Mangifera indica).…”

Antinociceptive effect of aqueous leaves extract of Fagara tessmannii on acetic acid-induced pain in Wistar albino rats

“…Dichloromethane extract of L. molleoides was reported to exhibit anti-inflammatory activity and immunostimulant activity on normal lymphocytes [55] and resorcinol 1,3-dihydroxy-5-(tridec-4',7'-dienyl)-benzene was identified as the major constituent and responsible for their biological activities. [56] in their work on isolation, characterization and confirmation of 5-alkenyl resorcinols from dichloromethane extract of L. molleoides using 1H NMR, 13C NMR spectral studies reported the presence of five resorcinols subunit in all of them with different side chains with various degrees of unsaturation.…”