Gastroprotective effect of Senecio candicans DC on experimental ulcer models

Lakshmanan, Hariprasath; Raman, Jegadeesh; Raaman, Nanjian

doi:10.1016/j.jep.2012.01.002

Cited by 25 publications

(11 citation statements)

References 17 publications

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“…Ulcer induction with diclofenac sodium treatment was significantly ( p < 0.05) decreased by the simultaneous administration of DSME. Similar results have been reported in previous studies as well [23]. Presence of various secondary metabolites, such as flavonoids, terpenoids, tannins, and phenolic compounds exhibit diversified biochemical and pharmacological activities including antioxidant and antitumor properties [24].…”

Section: Discussionsupporting

confidence: 86%

Gastroprotective Potential of Dalbergia sissoo Roxb. Stem Bark against Diclofenac-Induced Gastric Damage in Rats

Khan¹,

Khan²

2013

Osong Public Health and Research Perspectives

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ObjectivesDalbergia sissoo Roxb. stem bark possesses anti-inflammatory, antipyretic, and antioxidant properties. This plant is used traditionally in the Indian system of medicine to treat emesis, ulcers, leucoderma, dysentery, stomach complaints, and skin disorders. This study was conducted to evaluate the antiulcer effects of D. sissoo stem bark methanol extract (DSME) against the diclofenac sodium-induced ulceration in rat.MethodsThe DSME (200 mg/kg and 400 mg/kg body weight) was orally administered to rats once a day for 10 days in diclofenac-treated rats. The gastroprotective effects of DSME were determined by assessing gastric-secretory parameters such as volume of gastric juice, pH, free acidity, and total acidity. Biochemical studies of gastric mucosa were conducted to estimate the levels of nonprotein sulfhydryls (NP-SHs), lipid peroxidation [thiobarbituric acid reactive substances (TBARSs)], reduced glutathione (GSH), hydrogen peroxide (H2O2), levels of scavenging antioxidants, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), and myeloperoxidase (MPO). Moreover, adherent mucus content and histological studies were performed on stomach tissues.ResultsAdministration of DSME significantly decreased the ulcer index, TBARSs, H2O2, and MPO activity in gastric mucosa of the ulcerated rats. Activities of enzymic antioxidants, CAT, SOD, GSH-Px, GST and GSH, and NP-SH contents were significantly increased with DSME administration in the gastric mucosa of diclofenac-treated rats. Volume of gastric juice, total and free acidity were decreased, whereas pH of the gastric juice was increased with the administration of DSME + diclofenac. Our results show that DSME administration is involved in the prevention of ulcer through scavenging of free radicals. Results of histopathological studies supported the gastroprotective activities of DSME.ConclusionThe results of this study showed that DSME exhibit potential gastroprotective activity probably due to its antioxidant and cytoprotection ability.

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Section: Discussionsupporting

confidence: 86%

Gastroprotective Potential of Dalbergia sissoo Roxb. Stem Bark against Diclofenac-Induced Gastric Damage in Rats

Khan¹,

Khan²

2013

Osong Public Health and Research Perspectives

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“…The leaf decoction of the plant has been used for the treatment of gastric ulcer by the people in various parts of Nilgiris and the gastroprotective activity was confirmed in our previous study (Hariprasath et al, 2012). The study highlighted that the aqueous extract of S. candicans can prevent gastric ulcer either by markedly decreasing lipid peroxidation and subsequent oxidative damage or by free radical scavenging activity.…”

Section: Introductionsupporting

confidence: 53%

“…A number of active compounds have been characterized from these plants: Eremophilanes (Zdero et al, 1989), sesquiterpenoids (Bohlmann and Ziesche, 1981), diterpenoids (Cheng et al, 1993), triterpenoids (Ruicker et al, 1999), pyrrolizidines (Bohlmann et al, 1986) and shikimic acid derivatives (Barrero et al, 1988) exhibiting a range of bioactivities including antimicrobial (Perez et al, 1999), cytotoxic (Loizzo et al, 2007), molluscidal (Grace and Khattab, 1998), gastroprotective (Hariprasath et al, 2012) and antibacterial (El-Shazly et al, 2002) properties.…”

Section: Introductionmentioning

confidence: 99%

In vitro propagation of Senecio candicans DC and comparative antioxidant properties of aqueous extracts of the in vivo plant and in vitro-derived callus

Lakshmanan

Raman

Pandian

et al. 2015

South African Journal of Botany

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a b s t r a c tSenecio candicans DC is an endemic sub-shrubby climber and the hot water extract of this plant is being used traditionally for the treatment of gastric ulcer. The first objective of the present study was to design a standardized protocol for in vitro regeneration of S. candicans from leaf explants and compare the antioxidant activities of aqueous extracts of in vitro calluses and in vivo leaves by three different methods. Callus was initiated on Murashige and Skoog's (MS) basal media supplemented with various concentrations (0.5 mg L −1 to 2.0 mg L −1 ) and combinations of auxins and cytokinins under dark incubation for 2 weeks. The percentage of callus induction (PCI) and the fresh weights were recorded after 28 days of culture. The fresh weights were again recorded after 4 weeks of sub-culture to determine the relative fresh weight growth (RFWG). The highest PCI of 87% and RFWG of 3.245 were obtained on an MS medium supplemented with 6-benzyl amino purine (BA) 2 mg L −1 and indole-3-acetic acid (IAA) 2 mg L −1 . The callus obtained after 28 days of culture were inoculated on MS medium supplemented with different growth regulators. The maximum average shoot length (4.28 ± 0.27 cm) and maximum percentage of shoot induction (81%) was observed on MS medium supplemented with BA (2.0 mg L −1 ) + IAA (1.0 mg L −1 ). The maximum root induction percentage (90%) from shoots was observed on half strength MS medium fortified with 3.0 mg L −1 α-naphthalene acetic acid (NAA) alone. The antioxidant activity of in vivo leaf was significantly high compared to the in vitro callus in all the three antioxidant assays. A linear correlation between antioxidant activity and the total phenolic content was observed. The current protocol for in vitro regeneration would pave the way for further research on the isolation of bioactive compounds including antioxidants by cell suspension culture.

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“…Preliminary screening revealed the presence of alkaloids, tannins, saponins, terpenoids and flavonoids affirming an earlier report by Adeniyi et al (2010). Some alkaloids have been reported to have gastroprotective effects (Gadekar et al, 2010;Hariprasath et al, 2012;Nwidu and Nwafor, 2009). Tannins have also been reported to contribute immensely in gastroprotection (Dragana et al, 2009;Vasconcelos et al, 2010) while some saponins also protect the gut from ulcerogenic agents (Yoshikawa et al, 2008;Nwidu and Nwafor, 2009).…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Effect and Safety Assessment of <i>Zanthoxylum Zanthoxyloides</i> (Lam) Waterm Root Bark Extract

Günther¹

2012

American Journal of Pharmacology and Toxicology

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Problem statement: Gastrointestinal ulcers account significantly for morbidity and mortality in Ghana. The study therefore investigated the gastroprotective effect of an ethanolic root bark extract of Zanthoxylum zanthxyloides and its safety for us. Approach: Gastric ulceration was induced in Sprague-Dawley rats with Indomethacin (25 mg kg Index and Curative Ratio were determined. A histological study of the gastric mucosa was also performed. The extract's effect on an isolated guinea-pig ileum preparation was investigated to elucidate its possible mechanism of action. Safety assessments involving, organ weight to body weight ratio determination, hematological analysis and liver function tests were performed. Results: The extract significantly decreased (p≤0.001) the number of ulcers per stomach and the Ulcerative Index (similar to Esomeprazole) and significantly increased (p≤0.001) the Curative Ratio in a dose-dependent manner. It completely corrected the architectural distortions caused by gastric ulceration and inhibited significantly (p≤0.001) the contractile responses of the isolated guinea-pig ileum to Acetylcholine, Nicotine and Histamine in a manner comparable to reference antagonists. The extract had no significant effect (p>0.05) on organ weight to body ratio and hematological profile. Plasma levels of Alanine transaminase and Alkaline phosphatase decreased significantly (p≤0.001) in extract and Esomeprazole-treated ulcerated rats. Levels of Gamma-glutamyl transferase, Total bilirubin (direct and indirect) however increased significantly (p≤0.01-0.001). Conclusion/Recommendations: Per the findings, the ethanolic root bark extract of Zanthoxylum zanthoxyloides has gastroprotective effect in Sprague-Dawley rats working possibly via antimuscarinic or antihistaminic mechanism. It however has a potential of causing cholestasis hence liver function should be monitored.

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Gastroprotective effect of Senecio candicans DC on experimental ulcer models

Cited by 25 publications

References 17 publications

Gastroprotective Potential of Dalbergia sissoo Roxb. Stem Bark against Diclofenac-Induced Gastric Damage in Rats

Gastroprotective Potential of Dalbergia sissoo Roxb. Stem Bark against Diclofenac-Induced Gastric Damage in Rats

In vitro propagation of Senecio candicans DC and comparative antioxidant properties of aqueous extracts of the in vivo plant and in vitro-derived callus

Gastroprotective Effect and Safety Assessment of <i>Zanthoxylum Zanthoxyloides</i> (Lam) Waterm Root Bark Extract

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