ObjectivesDalbergia sissoo Roxb. stem bark possesses anti-inflammatory, antipyretic, and antioxidant properties. This plant is used traditionally in the Indian system of medicine to treat emesis, ulcers, leucoderma, dysentery, stomach complaints, and skin disorders. This study was conducted to evaluate the antiulcer effects of D. sissoo stem bark methanol extract (DSME) against the diclofenac sodium-induced ulceration in rat.MethodsThe DSME (200 mg/kg and 400 mg/kg body weight) was orally administered to rats once a day for 10 days in diclofenac-treated rats. The gastroprotective effects of DSME were determined by assessing gastric-secretory parameters such as volume of gastric juice, pH, free acidity, and total acidity. Biochemical studies of gastric mucosa were conducted to estimate the levels of nonprotein sulfhydryls (NP-SHs), lipid peroxidation [thiobarbituric acid reactive substances (TBARSs)], reduced glutathione (GSH), hydrogen peroxide (H2O2), levels of scavenging antioxidants, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), and myeloperoxidase (MPO). Moreover, adherent mucus content and histological studies were performed on stomach tissues.ResultsAdministration of DSME significantly decreased the ulcer index, TBARSs, H2O2, and MPO activity in gastric mucosa of the ulcerated rats. Activities of enzymic antioxidants, CAT, SOD, GSH-Px, GST and GSH, and NP-SH contents were significantly increased with DSME administration in the gastric mucosa of diclofenac-treated rats. Volume of gastric juice, total and free acidity were decreased, whereas pH of the gastric juice was increased with the administration of DSME + diclofenac. Our results show that DSME administration is involved in the prevention of ulcer through scavenging of free radicals. Results of histopathological studies supported the gastroprotective activities of DSME.ConclusionThe results of this study showed that DSME exhibit potential gastroprotective activity probably due to its antioxidant and cytoprotection ability.
A survey was conducted to perform an economic analysis and to investigate determinants of sugarcane crop in district Charsadda in the year 2018. Three villages viz. Kamran Kalay, Aspandehri, and Sarfaraz Kalay were selected purposively. Primary data were collected with face to face interview method from 41 randomly selected sugarcane growers through structured questionnaire. The selection of farmers was based on proportional allocation technique in the selected villages. For data analysis, profit margin, gross margin and Cobb-Douglas production function were applied. The study found that the per acre profit of sugarcane was 289.82 US$. Labour and fertilizers costs were found major components in the total variable cost. The profit margin was obtained as 37.37%. Empirical results of regression model found seed, farm yard manure and fertilizer positive and significant determinants, with coefficients 0.5011, 0.2916 and 0.2796, respectively. While tractor and labour costs were noted insignificant. For the wider interest of sugarcane growers and for the growth of agriculture sector, the study recommends reduction in the prices of fertilizers and suggests the Government to develop high yielding Hybrid varieties and to improve the provision of certified/tested seed to the growers.
Assessment and analysis of soil slope stability is an important part of geotechnical engineering at all times. This paper examines the assessment of soil slope stability in fine-grained soils. The effect of change in shear strength (τ), shear stress (σ) and slope angle (β) on the factor of safety has been studied. It correlates shear strength with slope angle and shear stress by considering the horizontal seismic coefficients in both saturated and unsaturated conditions. The slope failure surface was considered a circular slip surface. Statistical package for social sciences (SPSS) and Slide, numerical modeling software and limit equilibrium slope stability analysis software, respectively, are used to find out the correlations between the three basic parameters. The slope angle varied from 70 to 88 degrees, which are the most critical values for slope angles, and a total of 200 analyses were performed. τ, β and σ are correlated, and the correlations are provided in the results section. The results indicate that the correlations developed between the parameters have a very close relationship. The applicability of the developed equations is above 99%. These correlations are applicable in any type of soil slope stability analysis, where the value of shear strength and factor of safety is required with the variation of slope angle and shear stress.
This paper generally deals with the slope stability analysis of soil and an easy way to stabilize the slope to achieve high shear strength. Correlations between Factor of Safety (FS) and soil parameters i.e. cohesion, friction and unit weight are developed in this paper. Correlations among factor of safeties in natural, stepped and nailed form are also developed using linear regression analysis. Soil is not a homogeneous material and its properties are changing in different conditions and in different places. In case of slopes, there are many ways to stabilize it by nailing or stepping techniques. In this paper, both these methods are investigated in detail and compared to each other to know that which method gives better result. The graphs which shows the percent improvement of safety value are provided in the result section. This paper is providing a summary of the slopes safety issues having different soil properties. A software namely Slide is used for Limit Equilibrium (LE) analysis of the pre-defined soil slope model. For correlations, MS Excel and SPSS software are used. The correlations equations are provided in the results section.
There are various slope stability analysis methods normally used to find the factor of safety of a slope. All the methods have different analysis techniques and formulation, due to which the results also varies in some cases. In this research article, all those methods are compared and the results are provided in graphical form to show the variation. The results can be used in any slope stability project to find the optimum value for factor of slope safety and hence can minimize the risk while designing any slope in hilly areas or in case of designing an earthen dam
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