Gastroprotective effect of Piper betle Linn. leaves grown in Sri Lanka

Arawwawala, L.D.A.M.; Arambewela, L.S.R.; Ratnasooriya, W.D.

doi:10.4103/0975-9476.128855

Cited by 25 publications

(13 citation statements)

References 18 publications

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“…The leaves of P. betle have been traditionally used in India, China and Thailand for prevention of oral malodor due to its anti-bacterial activity, as a mouth freshener and masticatory, for their wound healing property [160], to enhance digestive and pancreatic lipase stimulant activities [161], for prevention of catarrhal and pulmonary afflictions [162] and, for preventing secretion or bleeding as well as an aromatic stimulant and anti-flatulent agent [163]. In addition, the leaf of P. betel is also traditionally valued as an aphrodisiac [163] and for the treatment of a range of diseases such as halitosis, boils and abscesses, conjunctivitis, constipation, headache, hysteria, itches, mastitis, mastoiditis, leucorrhea, otorrhea, ringworm, swelling of gums, rheumatism, abrasion, cuts, injuries as well as scabies, mouth odor, cough remedy, bronchitis, and nosebleed while the root is famous for its female contraceptive effects [118,164,165,166,167]. Ding et al [121] have also reported on P. betle traditional uses in China for promoting blood circulation and is claimed to be useful in antiplatelet therapies and in the treatment of thrombotic diseases.…”

Section: Traditional Uses Of Piper Speciesmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

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Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

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Section: Traditional Uses Of Piper Speciesmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

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“…Piper betle L. is a traditional herbal medicinal and used in many traditional treatments as also as the health improvement effect in Vietnam. Traditionally, the positive effects of betle leaves and their derivatives have been exploited to treat a variety of open wound diseases like cuts, injuries, inflammations, cold cough, indigestion, halitosis, boils and abscesses, headache, mastoiditis, leucorrhea, abrasion [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of Piper betle L. extract on umbilical cord cells in vitro and potential treating cutaneous wound

Thị

Nguyễn

Hoang

2021

Heliyon

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This research aimed to test the effects of Piper betle L. from Vietnam on fibroblasts and UC-derived mesenchymal stem cells (UC-MSCs) from human umbilical cord (UC) on the scratch assay. We tested the extract at different concentrations and then assessed the level of expression of the factors involved in the inflammatory process on fibroblasts including IL-33, VCAM, CD248 by assay real time qPCR. At the concentrations of 0.025 μL/mL and 0.03 μL/mL, the extracts positively affected fibroblast proliferation and UC-MSCs. By contrast, the concentration of 0.058 μL/mL, the extract was toxic to UC-MSCs and fibroblast cell lines, the cells were no longer able to survive. qPCR results show that Piper betle L. extract has the ability to reduce the expression levels of IL-33 (50.8%), VCAM (32.1%), CD248 (46.13%) which trigger inflammatory processes, thereby reducing cellular stress and promoting the process of healing scratches. Our study revealed the proliferation capabilities of Piper betle L. extract from Vietnam In vitro. Hence, Piper betle L. could be recommended as a potential source of wound healing agents.

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“…So it can be used as anti-hypercholesterolemic agent in obese and hypercholesterolemic patients. In another experiment, hot aqueous extract and cold ethanolic extract of Piper betle shows gastro-protective activity in experimental rats [112] . Phyllanthus emblica extracts have been shown to prevent contrast-induced acute kidney injury in rat model [113] .…”

Section: Root Rhizome and Leavesmentioning

confidence: 92%

A Survey on Medicinal Plant Usage by Folk Medicinal Practitioners in Different Villages at Nalitabari Upazilla, Sherpur District, Bangladesh

Ferdoushi

Mahmud

Rana

et al. 2016

EJMP

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Folk medicinal practitioners play an important role in the primary health-care system of a substantial segment of the rural and urban population of Bangladesh. For hundreds of years, the population of Bangladesh has mainly relied on traditional medicinal practitioners known locally as "Kavirajes" or "Vaidyas" for treatment of various ailments. The mainstay of their formulation is medicinal plants, which is either administered orally or topically in the form of decoction, paste, pill, juice or direct administration of whole plant or plant part. The objective of this survey was to find out about medicinal plants used by the folk medicinal practitioners (Kavirajes) of Jhenaigati upazila to treat various ailments. Detailed information was collected from Kavirajes about plants, plant parts or combination of plants used, formulation of medicines, dosages as well as ailments for which the plants are used. Plant specimens were collected and dried on the field and later brought back and identified at the Bangladesh National Herbarium. It was observed that the Kavirajes used more than 140 plants. These plants were distributed into 65 families. The Fabaceae family provided the largest number of species (8) followed by both Cucurbitaceae (7) and Apocynaceae (7) families.

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Gastroprotective effect of Piper betle Linn. leaves grown in Sri Lanka

Cited by 25 publications

References 18 publications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Influence of Piper betle L. extract on umbilical cord cells in vitro and potential treating cutaneous wound

A Survey on Medicinal Plant Usage by Folk Medicinal Practitioners in Different Villages at Nalitabari Upazilla, Sherpur District, Bangladesh

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