Gastroprotective effect of Neem (Azadirachta indica) bark extract: Possible involvement of H+-K+-ATPase inhibition and scavenging of hydroxyl radical

Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal Anti-inflammatory Drug-induced Gastropathy

“…Because the gastroprotective effect of SEGA (3a) is dependent on its iron-chelating and free radical-scavenging properties, we compared the gastroprotective effect of SEGA (3a) with that of the standard iron-chelating agent desferrioxamine (ED 50 (4,55,56). We found that SEGA (3a) (ED 50 ϭ 6.9 mg⅐kg Ϫ1 b.w.)…”

Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor

“…Neem (Azadirachta indica A. Juss) is a well known versatile medicinal plant that has a wide spectrum of biological activities including anti-inflammatory activity (33)(34)(35)(36)(37). The ethnopharmacological exploration and bioactivity testing of various neem compounds and extracts revealed its efficacy to prevent a wide variety of inflammatory disorders in infectious and non-infectious diseases (34, [37][38][39][40][41][42][43][44][45]. It is interesting to note that neem compounds show a beneficial effect in pathological conditions in which MIF-mediated pathologies are prevalent (6,10,11,14,16,17,21).…”

Antiulcer activity of the chloroform extract ofBauhinia purpurealeaf

“…The pathophysiology of this disorder has focused on the imbalance between aggressive and protective factors in the stomach including acid-pepsin secretion, mucosal barrier, mucus secretion, blood flow, cellular regeneration, prostaglandins, and epidermal growth factors . The current approach to control gastric ulceration is to promote gastroprotection, to inhibit gastric acid secretion, to block apoptosis, and to stimulate epithelial cell proliferation for healing (Bandyopadhyay et al, 2002). Proton pump inhibitors (e.g.…”