Gastroprotective effect of memantine in indomethacin-induced peptic ulcer in rats, a possible role for potassium channels

Rofaeil, Remon Roshdy

doi:10.1016/j.lfs.2018.12.005

Cited by 16 publications

(11 citation statements)

References 31 publications

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“…In previous studies, 25 mg/kg indomethacin is reported to lead to evident gastric damage [21][22][23][24]. In literature, the indomethacin-induced gastric damage is also referred to as the gastric ulcer [25,26]. Our experiment results revealed that indomethacin led to evident ulcer in gastric tissue, which complies with the literature.…”

Section: Discussionsupporting

confidence: 90%

The Protective Effect of Lercanidipine on Indomethacin-Induced Gastric Ulcers in Rats

Altuner

Kaya

Süleyman

2020

Braz. arch. biol. technol.

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Nonsteroidal anti-inflammatory drugs (NSAID) are among the aggressive factors causing gastric ulcer. They cause oxidative damage in the gastric tissue and lead to intracellular calcium deposition. Lercanidipine is a calcium channel blocker derived from the third generation dihydropyridine. The aim of this study is to analyse the effect of lercanidipine on indomethacin-induced gastric ulcers. A total of 24 albino Wistar male rats were divided into four groups; those who received indomethacin 25 mg/kg (IND), 5 mg mg/kg lercanidipine +25 mg/kg indomethacin (LC-5), 10 mg/kg lercanidipine+25mg/kg indomethacin (LC-10) and healthy rats who received 0.5 mL distilled water. Six hours after the application of indomethacin, the animals were sacrificed by high dose thiopental sodium. The stomachs of the animals were excised to perform a macroscopic analysis and the ulcerous region was measured on millimeter paper. All the stomachs were subjected to a biochemical analysis. Macroscopic analysis revealed hyperaemia on the gastric surface of the indomethacin group. Ulcerous tissues formed by oval, circular or irregular mucosal defects in varying diameters and depths were observed on the whole surface of the stomach. Hyperaemia was lower and ulcerous region was smaller in groups LC-5 and LC-10 compared to IND group. Malondialdehyde and myeloperoxidase levels were significantly lower and total glutathione and cyclooxygenase-1 activity were higher in groups LC-5 and LC-10. Lercanidipine did not change the cyclooxygenase-2 activity. Lercanidipine in doses 10 mg/kg is more effective compared to 5 mg/kg. Lercanidipinine can be useful in the treatment of NSAID-induced gastric damage.

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Section: Discussionsupporting

confidence: 90%

The Protective Effect of Lercanidipine on Indomethacin-Induced Gastric Ulcers in Rats

Altuner

Kaya

Süleyman

2020

Braz. arch. biol. technol.

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“…The most common proposed mechanism for the ulcerogenic effect of indomethacin is the inhibition of the gastric cytoprotective mediators, prostaglandins, particularly because of the inhibition of the COX pathway of arachidonic acid metabolism in the excessive production of leukotrienes and other products of 5-lipoxygenase pathway. The suppression of prostaglandins synthesis by NSAIDs (Nonsteroidal anti-inflammatory drugs) results in increased susceptibility to mucosal injury, gastroduodenal ulceration, the reduction of mucosal resistance, and the induction of oxidative stress and inflammatory status [ 62 , 63 ]. Ethanol consumption is known to be one of many factors responsible for gastric ulcer formation because of the production of oxygen-derived free radicals, such as superoxide anions, hydroxyl radicals, and lipid peroxides [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats

Sathyanarayanan

Sasidharan

Arunachalam

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Humans have been using herbs to prevent and cure various ailments since antiquity, and Ipomoea wightii is a significant medicinal plant known for its wide ethnobotanical uses. Although the plant is known to treat ulcers, there is no significant scientific validation. The present study aimed to assess the acute toxicity, subacute toxicity, and antiulcer properties of the leaf methanol extract of I. wightii (IWL). In the subacute study, the extracts were given orally at 100, 200, and 400 mg/kg doses for 28 days, and we analyzed the biochemical and histological parameters to evaluate the toxicity of IWL. Two different models were assessed to explore antiulcer properties, such as indomethacin- and ethanol-induced ulcer model. Ulcer areas and ulceration percentage histopathology of the stomach were used to study the efficacy of extracts. The acute toxicity study showed that IWL was safe to the maximum dose of 2000 mg/kg body weight. In a subacute toxicity study, the oral administration of IWL did not produce any mortality in the tested animals. The analysis of haematological, liver biochemical, kidney profile, lipid profile, and in vivo antioxidant parameters depicted that all the values were within the control limits after the experimental period and were considered nontoxic to animals. Additionally, the antiulcer study demonstrated a positive response of IWL in a dose-related manner (indomethacin- and ethanol-induced models). Macroscopic analysis showed that pretreatment with I. wightii leaf methanol extract significantly reduced the gastric lesion and decreased the ulceration area (14.52 mm2), demonstrating superior results to the positive control group (27.71 mm2). The histopathological analysis revealed that pretreatment with a high dose of 400 mg/kg of I. wightii leaf methanol extract and positive control group (omeprazole) markedly protected pathological effects, and the gastric mucosa appeared normal. In conclusion, I. wightii has solid nontoxic potential as a promising native herb for an integral therapy for the treatment of ulcers.

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“…Studies by [54], when co-administering glibenclamide, observed a loss of the gastroprotective effect of its test compound, which significantly increased the ulcer index. This effect was accompanied by increased levels of TNF-α and NF-κB in the gastric mucosa.…”

Section: Evaluation Involving Atp-sensitive Potassium Channels In the Gastroprotective Effectmentioning

confidence: 99%

Tablet of Spondias mombin L. Developed from Nebulized Extract Prevents Gastric Ulcers in Mice via Cytoprotective and Antisecretory Effects

et al. 2021

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Spondias mombin L. (Anacardiaceae) has a worldwide distribution and is present in all regions of Brazil. Its leaves, flowers and bark are used as teas in folk medicine to treat diseases of the digestive system. This study aimed to evaluate the acute non-clinical toxicity, gastroprotective activity, and the related mechanisms of action of nebulized extract and tablets based on dried Spondias mombin (SmNE). SmNE screening showed the presence of flavonoids (0.65%), polyphenols (25.50%), where the major compound is gallic acid. In the acute oral toxicity assay, a dose of 2000 mg/kg of SmNE administered orally in Swiss mice did not induce any behavioral changes. SmNE (250 or 500 mg. kg p.o) significantly reduced the ulcerative lesion area when compared to the control group in ethanol and non-steroidal anti-inflammatory drug (NSAIDs) models. Results showed that treatment with SmNE (250 mg/kg) reduced acid secretion and gastric content, accompanied with an increase in pH. Previous administration of indomethacin and glibenclamide reversed the protection provided by SmNE, confirming the participation of prostaglandins (PGs) and ATP-sensitive potassium channels (KATP) in its gastroprotective effect. The SmNE tablets met the pharmacopeial quality requirements with gastroprotective activity and similar protection in comparison to the isolated extract administrated. In conclusion, SmNe has a gastroprotective activity related to cytoprotective mechanisms, such as the participation of endogenous prostaglandins and KATP channels, having an anti-secretory effect with systemic action. The formulation obtained presented gastroprotective effects similar to the administration of the extract, the tablets showed favorable compression characteristics by the direct route and met the pharmacopeial quality requirements.

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Gastroprotective effect of memantine in indomethacin-induced peptic ulcer in rats, a possible role for potassium channels

Cited by 16 publications

References 31 publications

The Protective Effect of Lercanidipine on Indomethacin-Induced Gastric Ulcers in Rats

The Protective Effect of Lercanidipine on Indomethacin-Induced Gastric Ulcers in Rats

Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats

Tablet of Spondias mombin L. Developed from Nebulized Extract Prevents Gastric Ulcers in Mice via Cytoprotective and Antisecretory Effects

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